Pleural
A case of delayed recurrence of pleural mesothelioma with intradural invasion
Surgical Neurology International 2026 March 20 [Link] Hidetoshi Sato, Rui Omichi, Yuto Nigami, Nobuyuki Shimokawa Abstract Background: Pleural mesothelioma (PM) is a tumor of the pleural epithelium with a poor prognosis. Asbestos exposure is closely related to its occurrence. To date, there have been 13 reports of PM with intradural invasion. Case description: A 73-year-old male was…
Read MoreBrain Metastases in Diffuse Pleural Mesothelioma: Clinical, Histologic, and Molecular Correlates
JTO Clinical and Research Reports 2026 February 5 [Link] Antonio Ocejo, Clare Wilhem, Francis M Bodd, Andrea Arfe, Marjorie G Zauderer, Afsheen Iqbal, Juliana Eng, Yao Yu, Joshua A Budhu, Javin Schefflein, Robert Young, Mark G Kris, Nelson S Moss, Rabih Bou-Nassif, Charles B Simone 2nd, Prasad S Adusumilli, Jennifer L Sauter, Michael Offin Abstract…
Read MoreClinical, diagnostic and prognostic relevance of GATA3 in malignant pleural mesothelioma: a retrospective cohort study
BMC Cancer 2026 April 2 [Link] Alejandro Avilés-Salas, David Dávila Dupont, Alejandro Aranda-Gutierrez, Andrea Nallely Heredia-Jara, Enrique Caballé-Perez, Luis Cabrera-Miranda, Andrés F Cardona, José Lucio-Lozada, Cesar Castillo-Ruiz, Norma Hernandez-Pedro, Luis Corrales, Claudio Martin, Oscar Arrieta Abstract Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with a poor prognosis and limited treatment options. Recently, GATA3 has emerged as a useful adjunct immunohistochemical marker, especially for non-epithelioid subtypes. Although…
Read MoreThe genetics of cancer heterogeneity and mesothelioma
Frontiers in Oncology 2026 March 16 [Link] Lucian R Chirieac, Ritu Gill, Richard Attanoos Abstract Diffuse mesothelioma is an invasive cancer that originates from the cells in the smooth tissue lining (serosal membrane) that surrounds various body cavities. While most cases originate in the pleural lining of the thoracic cavity, a subset primarily involves the…
Read MoreThe genetics of cancer heterogeneity and mesothelioma
Frontiers in Oncology 2026 March 16 [Link] Lucian R Chirieac, Ritu Gill, Richard Attanoos Abstract Diffuse mesothelioma is an invasive cancer that originates from the cells in the smooth tissue lining (serosal membrane) that surrounds various body cavities. While most cases originate in the pleural lining of the thoracic cavity, a subset primarily involves the…
Read MoreRadioimmunotherapy for Malignant Mesothelioma Targeting C-ERC/Mesothelin
Pharmaceuticals 2026 March 18 [Link] Hirofumi Hanaoka, Aiko Yamaguchi, Masahiro Maeda, Tatsuya Segawa, Noboru Oriuchi Abstract Background/Objectives: Malignant mesothelioma has a poor prognosis and limited therapeutic options. C-ERC/mesothelin is highly expressed in mesotheliomas and is a potential target for radioimmunotherapy (RIT). This study evaluated the radiolabeled anti-C-ERC/mesothelin antibody mAb 22A31 as a therapeutic agent. Methods:…
Read MoreCase Report: Immune checkpoint inhibitor-triggered anti-Ma2 paraneoplastic encephalitis in sarcomatoid pleural mesothelioma: a fatal case
Frontiers in Oncology 2026 March 9 [Link] Ilker Nihat Okten, Tuba Baydaş Abstract Background: Neurological immune-related adverse events (N-irAEs) represent rare but potentially fatal complications of immune checkpoint inhibitor (ICI) therapy. Among these, encephalitis associated with paraneoplatic neuronal antibodies poses a major diagnostic and therapeutic challenge, as it blurs the distinction between drug-induced toxicity and…
Read MoreDynamic evaluation of the glycolytic determinants LDH-A and GLUT-1 enhances prognostic significance and their inhibition affects the growth of mesothelioma spheroids
Molecular Metabolism 2026 May [Link] Marika A Franczak, Federica Borea, Valentina Donati, Marta Aliprandi, Amir Avan, Valentina Doldi, Giulia Bononi, Kin Yip Tam, Carlotta Granchi, Ryszard T Smolenski, Paolo A Zucali, Filippo Minutolo, Godefridus J Peters, Elisa Giovannetti Abstract Energy metabolism plays a crucial role in determining the aggressiveness of cancer. In this study, we…
Read MorePhase 1/1b study of direct intratumoral injection of pleural mesothelioma of immunostimulant prior to surgical resection
The Journal of Thoracic and Cardiovascular Surgery 2026 March 24 [Link] Andrea S Wolf, Shubham Gulati, Komal Dolasia, Bailey Fitzgerald, Jorge Gomez, David Yankelevitz, Andres Salazar, Alexander M Tsankov, Thomas Marron, Raja Flores Abstract Objective: To evaluate the role of neoadjuvant injection of the viral mimic poly-ICLC (polyinosinic-polycytidylic acid-poly-l-lysine carboxymethylcellulose) in patients with pleural mesothelioma…
Read MorePhase 1/1b study of direct intratumoral injection of pleural mesothelioma of immunostimulant prior to surgical resection
The Journal of Thoracic & Cardiovascular Surgery 2026 March 24 [Link] Andrea S Wolf, Shubham Gulati, Komal Dolasia, Bailey Fitzgerald, Jorge Gomez, David Yankelevitz, Andres Salazar, Alexander M Tsankov, Thomas Marron, Raja Flores Abstract Objective: To evaluate the role of neoadjuvant injection of the viral mimic poly-ICLC (polyinosinic-polycytidylic acid-poly-l-lysine carboxymethylcellulose) in patients with pleural mesothelioma…
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