Journal of Clinical Medicine 2021 September 26 [Link] Alice Bellini, Andrea Dell’Amore, Chiara Giraudo, Antonella Modugno, Nicol Bernardinello, Stefano Terzi, Giovanni Zambello, Giulia Pasello, Andrea Zuin, Federico Rea Abstract Preoperative identification of unresectable pleural mesothelioma could spare unnecessary surgical intervention and accelerate the initiation of medical treatments. The aim of this study is to determine…

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Frontiers in Pharmacology 2021 September [Link] Derek B Oien, Sayantani Sarkar Bhattacharya, Jeremy Chien, Julian Molina, Viji Shridhar Abstract Mesothelioma is a rare cancer with disproportionately higher death rates for shipping and mining populations. These patients have few treatment options, which can be partially attributed to limited chemotherapy responses for tumors. We initially hypothesized that…

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Annals of Thoracic Surgery 2021 October 4 [Link] Moshe Lapidot, Emanuele Mazzola, Samuel Freyaldenhoven, Luis E De León, Michael T Jaklitsch, Raphael Bueno Abstract Background: Postoperative empyema following pleurectomy decortication (PDC) for malignant pleural mesothelioma (MPM) is a serious complication that necessitates prolonged hospitalization. The aim of this study was to determine the incidence, risk…

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Anticancer Research 2021 October 4 [Link] Kenji Araki, Naoya Yamamuro, Nahoko Tomonobu, Hiromi Kumon Abstract Background/aim: The adenovirus vector- carrying reduced expression in immortalized cell (REIC) gene (Ad-REIC) increases endoplasmic reticulum stress chaperone GRP78/BiP expression and induces the JNK-mediated apoptotic pathway. We aimed to determine whether Ad-REIC-induced apoptotic cell death can trigger immunogenic cell death…

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Molecular Cancer Research 2021 September 30 [Link] Aditya Wirawan, Ken Tajima, Fumiyuki Takahashi, Yoichiro Mitsuishi, Wira Winardi, Moulid Hidayat, Daisuke Hayakawa, Naohisa Matsumoto, Kenta Izumi, Tetsuhiko Asao, Ryo Ko, Naoko Shimada, Kazuya Takamochi, Kenji Suzuki, Masaaki Abe, Okio Hino, Yoshitaka Sekido, Kazuhisa Takahashi Abstract Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that has…

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The Journal of Biological Chemistry 2021 September 29 [Link] Yuki Ishii, Krishna K Kolluri, Adam Pennycuick, Xidan Zhang, Ersilia Nigro, Doraid Alrifai, Elaine Borg, Mary Falzon, Khalid Shah, Neelam Kumar, Sam M Janes Abstract Malignant pleural mesothelioma (MPM) is a rare, aggressive, and incurable cancer arising from the mesothelial lining of the pleura, with few…

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JTO Clinical and Research Reports 2021 May 18 [Link] Roger Y Kim, Nandita Mitra, Stephen J Bagley, Melina E Marmarelis, Andrew R Haas, Katharine A Rendle, Anil Vachani Abstract Introduction: Since the July 2017 National Comprehensive Cancer Network (NCCN) malignant pleural mesothelioma (MPM) guideline revision recommended second-line immune checkpoint inhibitors (ICIs), studies have suggested a…

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Biomolecules 2021 August 25 [Link] Danijela Štrbac, Vita Dolžan Abstract Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with…

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Cancers 2021 September 12 [Link] Michael Ried, Julia Kovács, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hauke Winter, Laura V Klotz, Rudolf Hatz, Julia Zimmermann, Bernward Passlick, Severin Schmid, Mohamed Hassan, Martin E Eichhorn, Hans-Stefan Hofmann Abstract In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity…

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