MesotheliomaCenter's

Mesothelioma-Line

Curated Journal Articles on Mesothelioma

Category Archives: Pleural

Malignant pleural mesothelioma; mesothelioma of the lining of the lungs, or pleura.

Amrubicin in Previously Treated Patients With Malignant Pleural Mesothelioma: A Phase II Study

Thoracic Cancer 2020 May 28 [Link] Takaya Ikeda, Shinnosuke Takemoto, Hiroaki Senju, Hiroshi Gyotoku, Hirokazu Taniguchi, Midori Shimada, Yosuke Dotsu, Yasuhiro Umeyama, Hiromi Tomono, Takeshi Kitazaki, Masaaki Fukuda, Hiroshi Soda, Hiroyuki Yamaguchi, Minoru Fukuda, Hiroshi Mukae Abstract Background: The aim of this study was to assess the efficacy and safety of amrubicin for previously treated […]

Comments Off on Amrubicin in Previously Treated Patients With Malignant Pleural Mesothelioma: A Phase II Study

Initial Evaluation of Nivolumab in Patients With Post-Operative Recurrence of Malignant Pleural Mesothelioma

Japanese Journal of Clinical Oncology 2020 May 28 [Link] Akifumi Nakamura, Nobuyuki Kondo, Toru Nakamichi, Ayumi Kuroda, Masaki Hashimoto 1, Seiji Matsumoto 1, Takashi Yokoi 2, Kozo Kuribayashi, Takashi Kijima, Seiki Hasegawa Abstract Background: Limited options exist for treating post-recurrence patients with malignant pleural mesothelioma (MPM). This study aimed to evaluate the efficacy and feasibility […]

Comments Off on Initial Evaluation of Nivolumab in Patients With Post-Operative Recurrence of Malignant Pleural Mesothelioma

The Hippo Pathway as a Driver of Select Human Cancers

Trends Cancer 2020 May 20 [Link] Aishwarya Kulkarni, Matthew T Chang, Joseph H A Vissers, Anwesha Dey, Kieran F Harvey Abstract The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Although Hippo has been linked to multiple aspects of cancer, its role in this disease […]

Comments Off on The Hippo Pathway as a Driver of Select Human Cancers

ERS/ESTS/EACTS/ESTRO Guidelines for the Management of Malignant Pleural Mesothelioma

European Journal of Cardiothoracic Surgery 2020 May 25 [Link] Isabelle Opitz, Arnaud Scherpereel, Thierry Berghmans, Ioannis Psallidas, Markus Glatzer, David Rigau, Philippe Astoul, Servet Bölükbas, Jeanette Boyd, Johan Coolen, Charlotte De Bondt, Dirk De Ruysscher, Valerie Durieux, Corinne Faivre-Finn, Dean A Fennell, Francoise Galateau-Salle, Laurent Greillier, Mir Ali Hoda, Walter Klepetko, Aude Lacourt, Phil McElnay, […]

Comments Off on ERS/ESTS/EACTS/ESTRO Guidelines for the Management of Malignant Pleural Mesothelioma

Metformin-loaded Chitosomes for Treatment of Malignant Pleural Mesothelioma – A Rare Thoracic Cancer

International Journal of Biological Macromolecules 2020 May 20 [Link] Snehal K Shukla, Amanda Chan, Vineela Parvathaneni, Vivek Gupta Abstract The purpose of this study was to design and evaluate chitosan dispersed lipid vesicles (chitosomes) as potential delivery carriers for repurposing metformin (Met) against malignant pleural mesothelioma. Chitosomes were prepared by directly hydrating the thin lipid […]

Comments Off on Metformin-loaded Chitosomes for Treatment of Malignant Pleural Mesothelioma – A Rare Thoracic Cancer

Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response

Cancers 2020 May 19 [Link] Natalia Trempolec, Charline Degavre, Bastien Doix, Davide Brusa, Cyril Corbet, Olivier Feron Abstract For poorly immunogenic tumors such as mesothelioma there is an imperious need to understand why antigen-presenting cells such as dendritic cells (DCs) are not prone to supporting the anticancer T cell response. The tumor microenvironment (TME) is […]

Comments Off on Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response

HEG1, BAP1, and MTAP Are Useful in Cytologic Diagnosis of Malignant Mesothelioma With Effusion

Diagnostic Cytopathology 2020 May 22 [Link] Kenzo Hiroshima, Di Wu, Shinji Hamakawa, Shingo Tsuruoka, Daisuke Ozaki, Hideki Orikasa, Mizue Hasegawa, Eitetsu Koh, Yasuo Sekine, Yoko Yonemori, Kazuki Nabeshima, Shoutaro Tsuji, Yohei Miyagi, Kohzoh Imai Abstract Background: The specificity and sensitivity of HEG1 for malignant mesothelioma (MM) is high. The use of BAP1/MTAP immunohistochemistry (IHC) is […]

Comments Off on HEG1, BAP1, and MTAP Are Useful in Cytologic Diagnosis of Malignant Mesothelioma With Effusion

Gender Differences in Molecular-Guided Therapy Recommendations for Metastatic Malignant Mesothelioma

Thoracic Cancer 2020 May 21 [Link] Hossein Taghizadeh, Sabine Zöchbauer-Müller, Robert M Mader, Leonhard Müllauer, Thomas Klikovits, Thomas Bachleitner-Hofmann, Mir A Hoda, Gerald W Prager Abstract Background: Malignant mesothelioma is an aggressive cancer and has a poor prognosis. Here, we analyzed the feasibility, molecular and gender aspects of targeted therapy recommendations for malignant mesothelioma based […]

Comments Off on Gender Differences in Molecular-Guided Therapy Recommendations for Metastatic Malignant Mesothelioma

Malignant Pleural Mesothelioma: Genetic and Microenviromental Heterogeneity as an Unexpected Reading Frame and Therapeutic Challenge

Cancers 2020 May 7 [Link] David Michael Abbott, Chandra Bortolotto, Silvia Benvenuti, Andrea Lancia, Andrea Riccardo Filippi, Giulia Maria Stella Abstract Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence in countries like Italy […]

Comments Off on Malignant Pleural Mesothelioma: Genetic and Microenviromental Heterogeneity as an Unexpected Reading Frame and Therapeutic Challenge

Localized Biphasic Malignant Mesothelioma Presenting as a Giant Pelvic Wall Mass: A Rare Case Report and Literature Review

BMC Medical Imaging 2020 May 6 [Link] Yunsong Liu, Jingjun Wu, Ying Zhao, Pengxin Zhang, Zhengyu Hua, Wan Dong, Tao Lin, Ailian Liu Abstract Background: Localized biphasic MPeM is rare in clinical practice, we reviewed 8 cases of localized biphasic MPeM (including our present case), and summarized the clinical and imaging features of the disease. […]

Comments Off on Localized Biphasic Malignant Mesothelioma Presenting as a Giant Pelvic Wall Mass: A Rare Case Report and Literature Review