Pleural
The role of non-coding RNAs in pleural mesothelioma
Translational Oncology 2025 September 29 [Link] Giulia Tonnini, Giulia Di Mauro, Maria Letizia Tramarin, Anna Meneghetti, Ilaria Bononi, Chiara Mazziotta, John Charles Rotondo, Elisa Mazzoni, Maria Rosa Iaquinta, Elisabetta Trabetti, Cristina Bombieri, Monica De Mattei, Mauro Tognon, Fernanda Martini Abstract Background: Pleural mesothelioma (PM) is a rare and highly aggressive tumor, primarily caused by asbestos…
Read MoreManganese-doped nanotheranostic system for MRI-guided photothermal therapy of malignant pleural mesothelioma: in vivo study
Frontiers in Chemistry 2025 September 11 [Link] Lichang Lei, Hongjiao Zi, ShaoLei Kang, Hui Duan, Zhenghua Zhang, Chao Gao, Ruoyun Xu, Dan Han Abstract Introduction: Magnetic Resonance Imaging (MRI)-guided photothermal therapy (PTT) holds significant promise for the treatment of solid tumors, however, its diagnostic and therapeutic efficacy in malignant pleural mesothelioma (MPM) remains underexplored. To…
Read MoreExternal validation of pathological T adjustments in the ninth edition of the pleural mesothelioma tumor-node-metastasis classification
Frontiers in Oncology 2025 September 10 [Link] Zheng Liu, Jingsheng Cai, Yun Li, Wenhan Weng Abstract Introduction: In the ninth edition pleural mesothelioma (PM) pathological (p) T staging, patients with fissural invasion are upgraded from T1 to T2. This study aimed to externally validate this staging modification. Methods: Resected pT1/2 PM patients were selected. The…
Read MoreDiagnosis of Mesothelioma Using Image Segmentation and Class-Based Deep Feature Transformations
Diagnostics 2025 September 18 [Link] Siyami Aydın, Mehmet Ağar, Muharrem Çakmak, Mesut Toğaçar Abstract Background/Objectives: Mesothelioma is a rare and aggressive form of cancer that primarily affects the lining of the lungs, abdomen, or heart. It typically arises from exposure to asbestos and is often diagnosed at advanced stages. Limited datasets and complex tissue structures…
Read MoreFL496, an FL118-derived small molecule, induces growth inhibition, senescence, and apoptosis of malignant pleural mesothelioma (MPM) cells, and exhibits anti-MPM tumor efficacy strikingly superior to the pemetrexed-cisplatin combination
Journal of Experimental and Clinical Cancer Research 2025 October 21 [Link] Ieman A M Aljahdali, Xiang Ling, Wenjie Wu, Wenchao Wang, Dan Li, Renyuan Zhang, Emma Zhang, Aimee Stablewski, Rami Azrak, Qingyong Li, Fengzhi Li Abstract Background: Malignant pleural mesothelioma (MPM) responds poorly to chemotherapy and is a highly progressive malignancy with a median survival…
Read MoreLong-term survival of nonoccupational pleural mesothelioma: a case report and review of the literature
Journal of Medical Case Reports 2025 October 21 [Link] Loreta Tobia, Elio Tolli, Adalgisa Ilaria Sedile, Vincenza Cofini, Stefano Necozione, Leila Fabiani Abstract Introduction: Malignant mesothelioma is an aggressive cancer that arises from the mesothelial cells lining the pleura, peritoneum, pericardium, or tunica vaginalis. While occupational exposure accounts for most cases, nonoccupational exposures (to ionizing…
Read MorePharmacogenomic Characterization of a Large Cohort of Patient-Derived Cell Lines Identifies Therapeutic Strategies for Pleural Mesothelioma
Cancer Research 2025 September 24 [Link] Jean-Baptiste Assié, Clément Meiller, Esther Stern, Julie Lasvergnas, Maya Arnould, Long Pan, François Montagne, Ruth Sequeiros, Charles Al Zreibi, Elaine Del Nery, Auguste Genovesio, Sylvie Lantuejoul, Françoise Le Pimpec-Barthes, Jessica Zucman-Rossi, Marie-Claude Jaurand, Christophe Blanquart, Ori Wald, Didier Jean Abstract Pleural mesothelioma (PM) urgently requires effective treatments. This study…
Read MoreEfficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in the treatment of diffuse pleural mesothelioma: a systematic review and meta-analysis
Frontiers in Immunology 2025 September 2 [Link] Peiyuan Sun, Dandan Song, Ning Ma, Shufu Hou, Lei Liu, Jing Gao, Yanyan Tian Abstract Background: While clinical trials confirm the therapeutic value of PD-1/PD-L1 and CTLA-4 inhibitors in diffuse pleural mesothelioma, their real-world safety and efficacy profiles remain incompletely defined. This meta-analysis synthesizes clinical evidence to comprehensively…
Read MoreRadiologist’s Guide to the Ninth Edition TNM Staging System for Quantitative and Qualitative Assessment of Pleural Mesothelioma
Radiology 2025 September [Link] David J Murphy, Anna K Nowak, Thomas Frauenfelder, Michelle S Ginsberg, Hiroshi Kodama, Veronica Lenge de Rosen, Maria Mayoral, Christopher Straus, Giulia Benedetti, Valerie W Rusch, Ritu R Gill Abstract Pleural mesothelioma is a highly lethal, rare thoracic malignant neoplasm arising from mesothelial cells. Previous versions of the clinical TNM staging…
Read MoreInclusion of anti-vascular therapy as a promising option for later-line treatment of malignant pleural mesothelioma: a retrospective study
Journal of Thoracic Disease 2025 August 31 [Link] Keda Shao, Di Wu, Qian Wang, Dong Wang, Yue Hao, Bihui Li, Jianhui Huang, Ziyan Yang, Jingxun Wu, Long Huang, Wenfeng Li, Rui Meng, Jian Feng, Jianfei Fu, Huijing Feng, Shengjie Yang, Ling Xu, Xuefei Shi, Miao Li, Yujuan Wang, Chunwei Xu, Zhengbo Song Abstract Background: Malignant…
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