Radiation
Epidemiology, diagnosis and treatment of the malignant pleural mesothelioma, a narrative review of literature
Journal of Thoracic Disease 2021 April [Link] Sven Oliver Schumann, Gregor Kocher, Fabrizio Minervini Abstract The malignant pleural mesothelioma is a very aggressive tumor which is arising from mesothelial cells and is associated with asbestos exposure. It is a heterogeneous cancer that shows a complex pattern of molecular changes, including genetic, chromosomic, and epigenetic abnormalities.…
Read MoreControversies in the role of radiotherapy in pleural mesothelioma
Translational Lung Cancer Research 2021 April [Link] Gerard G Hanna, Thomas John, David L Ball Abstract Malignant pleural mesothelioma is an uncommon thoracic cancer with a relatively poor outcome, which has only seen modest improvements when compared to non-small cell lung cancer. The mainstays of treatment have been surgery and systemic therapy, with radiation reserved…
Read MoreMalignant pleural mesothelioma: Comparison of surgery-based trimodality therapy to medical therapy at two tertiary academic institutions
Lung Cancer 2021 June [Link] Frédéric Larose, Nicholas Quigley, Yves Lacasse, Simon Martel, Loïc Lang-Lazdunski Abstract Objectives: Medical management based on palliative chemotherapy is currently the standard of care in malignant pleural mesothelioma (MPM). Median survival of 12-16 months has been reported with modern chemotherapy regimens with or without anti-angiogenic agents. Multimodality therapy incorporating cytoreductive…
Read More[The Current Therapy of Asbestos-Associated Malignant Pleural Mesothelioma – An Expert Consensus Paper]
Pneumologie 2021 May 4 [Link] C Aigner, T Brüning, W E E Eberhardt, M Härter, H-P Kaelberlah, M Metzenmacher, R Shah, C Taube, M Thomas Abstract Asbestos-related mesotheliomas belong to the group of the most frequent occupational diseases in Germany, reaching about 1,000 new cases per year. The disease has a dismal prognosis because most…
Read MoreMetformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
Frontiers in Cell and Development Biology 2021 January 18 [Link] Marika Rossini, Fernanda Martini, Elena Torreggiani, Francesca Fortini, Giorgio Aquila, Francesco Vieceli Dalla Sega, Simone Patergnani, Paolo Pinton, Pio Maniscalco, Giorgio Cavallesco, Paola Rizzo, Mauro Tognon Abstract Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity.…
Read MoreSwitch-maintenance gemcitabine after first-line chemotherapy in patients with malignant mesothelioma (NVALT19): an investigator-initiated, randomised, open-label, phase 2 trial
The Lancet Respiratory Medicine 2021 January 27 [Link] Cornedine J de Gooijer, Vincent van der Noort, Jos A Stigt, Paul Baas, Bonne Biesma, Robin Cornelissen, Nico van Walree, Robbert C van Heemst, Magdolen Youssef-El Soud, Harry J M Groen, Agnes J Staal-van den Brekel, Wieneke A Buikhuisen, Gerben P Bootsma, Floris Dammeijer, Harm van Tinteren,…
Read MoreSurgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial
The Lancet Oncology 2021 January 12 [Link] B C John Cho, Laura Donahoe, Penelope A Bradbury, Natasha Leighl, Shaf Keshavjee, Andrew Hope, Prodipto Pal, Michael Cabanero, Kasia Czarnecka, Karen McRae, Ming-Sound Tsao, Marc de Perrot Abstract Background: A novel approach for managing malignant pleural mesothelioma, surgery for mesothelioma after radiotherapy (SMART), consisting of a short…
Read MoreProlonged survival after multimodal therapy for pleural mesothelioma: Don’t give up the follow-up. A case report
Annals of Medicine and Surgery 2020 November 11 [Link] Julien Guinde, Bertrand Chollet, Sophie Laroumagne, Hervé Dutau, Philippe Astoul Abstract Malignant Pleural mesothelioma (MPM) is a rare disease which is associated with a poor prognosis. Front line chemotherapy represents the cornerstone in the management of MPM, and the place of radical surgery is controversial and…
Read MoreHyperthermic intraoperative intrapleural chemotherapy and surgical cytoreduction as part of multimodal treatment of malignant pleural mesothelioma – case report M. Szkorupa1, D. Klos1, J. Chudacek1, J. Hanuliak1, M. Stasek1, O. Fischer2, R. Lemstrova3
Rozhledy V Chirurgii Fall 2020 [Link] M Szkorupa, D Klos, J Chudacek, J Hanuliak, M Stasek, O Fischer, R Lemstrová Abstract Malignant pleural mesothelioma is one of the most aggressive malignancies with a very poor prognosis. Multimodal treatment consisting of three modalities – chemotherapy, radiotherapy and cytoreductive surgery is optimal. The use of new therapeutic…
Read MoreLocoregional control and toxicity after pleurectomy/decortication and intensity-modulated pleural radiation therapy in patients with malignant pleural mesothelioma
Thoracic Cancer 2020 October 8 [Link] Oscar Arrieta, Francisco Lozano-Ruiz, Monika Blake-Cerda, Rodrigo Catalán, Luis Lara-Mejía, Miguel Ángel Salinas, Federico Maldonado-Magos, José F Corona-Cruz Abstract Background: Treatment of malignant pleural mesothelioma (MPM) represents a major challenge for oncologists. Multimodality treatment, which generally involves induction chemotherapy, surgery and radiotherapy have recently shown promising results. The aim…
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