Gemcitabine (Gemzar)
mTOR Mediates Survival Signals in Malignant Mesothelioma Grown as Tumor Fragment Spheroids
American Journal of Respiratory Cell and Molecular Biology. 2008 May 29. [Epub ahead of print] [Link] Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura S, Gordon GJ, Broaddus VC. University of California San Francisco, Lung Biology Center, San Francisco, CA, United States. Abstract Solid tumors such as mesothelioma exhibit a…
Read MoreThe role of muscle flap in preventing bronchus stump insufficiency after pneumonectomy for malignant pleural mesothelioma in high-risk patients
Interactive CardioVascular and Thoracic Surgery. 2008 Apr 1 [Epub ahead of print] [Link] Beshay M, Carboni G, Hoksch B, Reymond MA, Schmid RA. University Hospital of Berne, Switzerland. Abstract Bronchus stump insufficiency (BSI) is one of the major complications after pneumonectomy; we analyzed all patients who underwent extra pleural pneumonectomy (EPP) for malignant pleural mesothelioma…
Read MoreCytotoxic activities of nucleoside and nucleobase analog drugs in malignant mesothelioma: Characterization of a novel nucleobase transport activity
Biochemical Pharmacology. 2008 May 15;75(10):1901-11. Epub 2008 Feb 16. [Link] Damaraju D, Damaraju VL, Brun M, Mowles D, Kuzma M, Berendt RC, Sawyer MB, Cass CE. Department of Oncology, University of Alberta, Alberta, Canada. Abstract This study was designed to evaluate the cytotoxic activity of several nucleoside and nucleobase analog drugs as possible new agents…
Read MorePhase II Trial of Pemetrexed and Gemcitabine in Chemotherapy-Naïve Malignant Pleural Mesothelioma
Journal of Clinical Oncology. 2008 Mar 20;26(9):1465-71. [Link] Jänne PA, Simon GR, Langer CJ, Taub RN, Dowlati A, Fidias P, Monberg M, Obasaju C, Kindler H. Dana Farber Cancer Institute, Lowe Center for Thoracic Oncology, 44 Binney St, Dana D820A, Boston, MA 02115, USA. pjanne@partners.org Abstract Purpose: Pemetrexed and gemcitabine have single-agent activity in malignant…
Read MoreGemcitabine and vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma
Cancer. 2008 Feb 19 [Epub ahead of print] [Link] Zucali PA, Ceresoli GL, Garassino I, De Vincenzo F, Cavina R, Campagnoli E, Cappuzzo F, Salamina S, Soto Parra HJ, Santoro A. Department of Medical Oncology and Hematology, Humanitas Clinical Institute of Rozzano, Milan, Italy. Abstract Background: Pemetrexed-cisplatin chemotherapy is the standard of care in the…
Read MoreImatinib mesylate enhances therapeutic effects of gemcitabine in human malignant mesothelioma xenografts
Clinical Cancer Research. 2008 Jan 15;14(2):541-8. [Link] Bertino P, Piccardi F, Porta C, Favoni R, Cilli M, Mutti L, Gaudino G. Authors’ Affiliations: Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences and Drug and Food Biotechnology Center, University of Piemonte Orientale “A. Avogadro,” Novara, Italy. Abstract Purpose: Platelet-derived growth factor receptor β (PDGFRβ), frequently activated…
Read MoreA phase 2 study of gemcitabine and epirubicin for the treatment of pleural mesothelioma: a North Central Cancer Treatment Study, N0021
Cancer. 2008 Jan 25 [Epub ahead of print] [Link] Okuno SH, Delaune R, Sloan JA, Foster NR, Maurer MJ, Aubry MC, Rowland KM Jr, Soori GS, Nikcevich DA, Kardinal CG, Northfelt DW, Adjei AA. Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota. Abstract Background: The North Central Cancer Treatment Group (NCCTG) conducted a…
Read MoreGemcitabine and cisplatin in unresectable malignant mesothelioma of the pleura: A phase II study of the Southwest Oncology Group (SWOG 9810)
Lung Cancer. 2007 Nov 13 [Epub ahead of print] [Link] Kalmadi SR, Rankin C, Kraut MJ, Jacobs AD, Petrylak DP, Adelstein DJ, Keohan ML, Taub RN, Borden EC. Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH, United States. Abstract Purpose: The purpose of this open-label phase II SWOG study was to evaluate the activity of…
Read MorePhase I and Pharmacokinetic Study of Imatinib Mesylate (Gleevec) and Gemcitabine in Patients with Refractory Solid Tumors
Clinical Cancer Research. 2007 Oct 1;13(19):5876-82. [Link] Ali Y, Lin Y, Gharibo MM, Gounder MK, Stein MN, Lagattuta TF, Egorin MJ, Rubin EH, Poplin EA. The Cancer Institute of New Jersey, University of Medicine & Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA. Abstract Purpose: Preclinical data shows…
Read MoreIntracavitary mass as the initial manifestation of primary pericardial mesothelioma: a case report
Angiology. 2007 Apr-May;58(2):255-8. [Link] Peregud-Pogorzelska M, Kaźmierczak J, Wojtarowicz A. Department of Cardiology, Pomeranian Medical University, Szczecin, Poland. mperegud@iscnet.pl Abstract A 31-year-old woman presented with a 3-month history of progressing fatigue and effort dyspnea. Echocardiography depicted a tumor within the free wall of the right ventricle and right atrium, located on both sides of the…
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