MicroRNA
MicroRNA gene expression signatures in long-surviving malignant pleural mesothelioma patients
Genomics Data 2016 June 20 [Link] Lin RC, Kirschner MB, Cheng YY, van Zandwijk N, Reid G Abstract Malignant pleural mesothelioma (MPM) is a tumor originating in the mesothelium, the membrane lining the thoracic cavities, and is induced by exposure to asbestos. Australia suffers one of the world’s highest rates of MPM and the incidence…
Read MoreP2X7 targeting inhibits growth of human mesothelioma
Oncotarget 2016 July 6 [Epub ahead of print] [Link] Amoroso F, Salaro E, Falzoni S, Chiozzi P, Giuliani AL, Cavallesco G, Maniscalco P, Puozzo A, Bononi I, Martini F, Tognon M, Di Virgilio F Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor refractory to anti-blastic therapy. MPM cells show several genetic and biochemical defects,…
Read MoreDiagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis
Oncotarget 2016 June 1 [Epub ahead of print] [Link] Micolucci L, Akhtar MM, Olivieri F, Rippo MR, Procopio AD. Abstract BACKGROUND: Asbestos is a harmful and exceptionally persistent natural material. Malignant mesothelioma (MM), an asbestos-related disease, is an insidious, lethal cancer that is poorly responsive to current treatments. Minimally invasive, specific, and sensitive biomarkers providing…
Read MoreKCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma
Molecular Cancer 2016 June 1 [Link] Cheng YY, Wright CM, Kirschner MB, Williams M, Sarun KH, Sytnyk V, Leshchynska I, Edelman JJ, Vallely MP, McCaughan BC, Klebe S, van Zandwijk N, Lin RC, Reid G. Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive, locally invasive, cancer elicited by asbestos exposure and almost invariably a…
Read MoreClinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer
Epigenomics 2016 May 17 [Epub ahead of print] [Link] Reid G1, Kao SC, Pavlakis N, Brahmbhatt H, MacDiarmid J, Clarke S, Boyer M, van Zandwijk N. Abstract miRNAs are responsible for post-transcriptional control of gene expression, and are frequently downregulated in cancer. It has become well established that restoring miRNA levels can inhibit tumor growth,…
Read MoreOverexpression of micro ribonucleic acid-591 inhibits cell proliferation and invasion of malignant pleural mesothelioma cells.
Thoracic Cancer 2016 April 26 [epub ahead of print] [Link] Cheng S, Xu Y, Shi Z, Lin Y, Hoang CD, Zhang X. Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive cancer refractory to current therapies. Reduced expression of micro ribonucleic acid (miR)-591 in a range of cancer types has suggested it is a potent…
Read MorePrognostic and Therapeutic Implications of MicroRNA in Malignant Pleural Mesothelioma
MicroRNA 2016 January 28 [Epub ahead of print] [Link] Truini A, Coco S, Genova C, Mora M, Dal Bello MG, Vanni I, Alama A, Rijavec E, Barletta G, Biello F, Maggioni C, Grossi F. Abstract Malignant Pleural Mesothelioma (MPM) is an aggressive disease characterized by a dismal prognosis, mainly due to late diagnosis. To date,…
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