Case Study
Asbestos in Belgium: an underestimated health risk. The evolution of mesothelioma mortality rates (1969-2009)
International Journal of Occupational Environmental Health. 2014 April-June. [Link] Deboosere P, Van den Borre L. Abstract Background Although Belgium was once a major international manufacturer of asbestos products, asbestos-related diseases in the country have remained scarcely researched. Objectives The aim of this study is to provide a descriptive analysis of Belgian mesothelioma mortality rates in…
Read MoreIncidence of pleural mesothelioma in a community exposed to fibres with fluoro-edenitic composition in Biancavilla (Sicily, Italy)
Annali dell’Istituto superiore di sanità . 2014. [Link] Bruno C, Cascone G, Cernigliaro A, Comba P, De Santis M, Fazzo L, Giurdanella MC, Nicita C, Rollo PC, Scondotto S, Spata E, Tumino R, Zona A. Abstract Introduction Amphibolic fibres with fluoro-edenitic composition characterize Biancavilla soil, including the major quarry from which building materials have been extensively…
Read MoreSecond-line gemcitabine-based chemotherapy regimens improve overall 3-year survival rate in patients with malignant pleural mesothelioma: a multicenter retrospective study
Medical Oncology 2014 August. [Epub 2014 June 24] [Link] Akca Z, Buyukcelik A, Cihan YB, Coskun HS, Erden A, Gunduz S, Karaca H, Mutlu H. Abstract In the present study, we aimed to evaluate the effectiveness of second-line gemcitabine-based chemotherapy regimens on overall survival (OS) in malignant pleural mesothelioma (MPM) patients receiving first-line pemetrexed-based regimens.…
Read MoreSynchronous pleural and peritoneal malignant mesothelioma: a case report and review of literature
International Journal of Clinical and Experimental Pathology. 2014 April 15. [Link] Bonaparte E, Bosari S, Ferrero S, Firori S, Gaudisos G, Gobbo AD, Palleschi A, Tabano S. Abstract The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has…
Read MoreB7-H1 Expression in Malignant Pleural Mesothelioma is Associated with Sarcomatoid Histology and Poor Prognosis
Journal of Thoracic Oncology. 2014 July. [Link] Dong H, Harrington SM, Krco CJ, Kwon ED, Mansfield AS,Peikert T, Roden AC, Sheinin YM. Abstract Introduction B7 homolog 1 (B7-H1; aka programmed cell death 1 ligand 1) is a negative costimulatory molecule that is associated with poor prognosis in many tumor types. Given the poor prognosis and…
Read MoreCarbonic Anhydrase IX (CAIX) Does Not Differentiate Between Benign and Malignant Mesothelium
American Journal of Clinical Pathology. 2014 July. [Link] Ananthanarayanan V, Antic T, FRCPath, Husain AN, Krausz T, Tretiakova M. Abstract Objectives To examine carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma that recently has been described in malignant effusions. Methods Pleural and peritoneal fluids with the following diagnoses-reactive (n = 23), carcinoma (n…
Read MoreThird-space fluid distribution of pemetrexed in non-small cell lung cancer patients
Cancer Chemotherapy and Pharmacology. 2014 June 17. [Epub ahead of print] [Link] Hansen SH, Honore PH, Joensen SJ, Mellemgaard A, Olsen M. Abstract Aim Hydrophilic drugs particularly those with low plasma protein binding may accumulate in third-space fluid in the body. Cytotoxic drugs like methotrexate (MTX) cause damage in the tissue, and evacuation of the…
Read MoreTumors that mimic asbestos-related mesothelioma: time to consider a genetics-based tumor registry?
Frontiers in Genetics. 2014 May 30. [Link] Galbraith DA, James RC, Kerger BD. Abstract The diagnosis of mesothelioma is not always straightforward, despite known immunohistochemical markers and other diagnostic techniques. One reason for the difficulty is that extrapleural tumors resembling mesothelioma may have several possible etiologies, especially in cases with no meaningful history of amphibole…
Read MoreGene Expression of Mesothelioma in Vinylidene Chloride-exposed F344/N Rats Reveal Immune Dysfunction, Tissue Damage, and Inflammation Pathways
Toxicologic Pathology. 2014 June 23. [Epub ahead of print] [Link] Bhusari S, Blackshear PE, Clayton NP, Gerrish KE, Hoenerhoff, MJ, Hong HH, Nagai H, Pandiri AR, Peddada SD, Shockley KR, Sills RC, Ton TV, Wyde M. Abstract A majority (∼80%) of human malignant mesotheliomas are asbestos-related. However, non-asbestos risk factors (radiation, chemicals, and genetic factors)…
Read MoreDiagnostic Potential of miR-126, miR-143, miR-145, and miR-652 in Malignant Pleural Mesothelioma
The Journal of Molecular Diagnostics. 2014 May 31. [Epub ahead of print] [Link] Andersen CB, Andersen M, Grauslund M, Ravn J, Santoni-Rugiu E, Sorensen JB. Abstract Malignant pleural mesothelioma (MPM) is difficult to distinguish from reactive mesothelial proliferations (RMPs). It is uncertain whether miRNAs are useful biomarkers for differentiating MPM from RMPs. Thus, we screened…
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