Case Study
Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area
Genes, Chromosomes & Cancer. 2014 September 18 [Epub ahead of print] [Link] Betti M, Casalone E, Ferrante D, Romanelli A, Grosso F, Guarrera S, Righi L, Vatrano S, Pelosi G, Libener R, Mirabelli D, Boldorini R, Casadio C, Papotti M, Matullo G, Magnani C, Dianzani I. Abstract Inherited loss-of-function mutations in the BAP1 oncosuppressor gene…
Read MoremiR-379/411 cluster regulates IL-18 and contributes to drug resistance in malignant pleural mesothelioma
Oncology Reports. 2014 September 16 [Epub ahead of print] [Link] Yamamoto K, Seike M, Takeuchi S, Soeno C, Miyanaga A, Noro R, Minegishi Y, Kubota K, Gemma A. Abstract Malignant pleural mesothelioma (MPM) is a rapidly fatal malignancy that is increasing in incidence in Japan. In this study, we performed gene and microRNA (miRNA) expression…
Read MoreNon-Asbestos-related Malignant Pleural Mesothelioma
Internal Medicine. 2014 [Link] Kanbay A, Ozer Simsek Z, Tutar N, Yilmaz I, Buyukoglan H, Canoz O, Demir R. Abstract Malignant pleural mesothelioma (MPM) is an uncommon tumor derived from mesothelial lining cells. MPM has been described as an insidious neoplasm because of its long latency period. The tumor is typically found in patients several…
Read MoreMyxoid variant of peritoneal epithelioid malignant mesothelioma. A case report
Asbestos in commercial cosmetic talcum powder as a cause of mesothelioma in women
International Journal of Occupational Environmental Health. 2014 September 3. [Epub ahead of print] [Link] Gordon RE, Fitzgerald S, Millette J. Abstract Background Cosmetic talcum powder products have been used for decades. The inhalation of talc may cause lung fibrosis in the form of granulomatose nodules called talcosis. Exposure to talc has also been suggested as…
Read MoreMalignant pleural and peritoneal mesothelioma consequential to brief indirect asbestos exposure
Journal of Clinical Imaging Science. 2014 June 30. [Link] Singhal B, Kohli S, Sinhgal A, Kumar V. Abstract This report highlights that pleural and peritoneal mesothelioma can occur without direct asbestos exposure as was seen in our young patient. The patient had indirect exposure for as short as 3 months as a child, 15 years…
Read MoreDusted community: piloting a virtual peer-to-peer support community for people with an asbestos-related diagnosis and their families
Journal of Psychosocial Oncology. 2014 [Link] Kozlowski D, Provost SC, Tucker J, van der Zwan R. Abstract Individuals with an asbestos-related diagnosis and their carers face burdens including debilitating and life-limiting physical symptoms and medico-legal stressors. Feelings of social isolation are common. Increasing social connectedness can lead to increased feelings of personal empowerment and may…
Read MoreLow PIAS3 expression in malignant mesothelioma is associated with increased STAT3 activation and poor patient survival
Clinical Cancer Research. 2014 August 14 [Epub ahead of print] [Link] Dabir S, Kluge A, Kresak AM, Yang M, Fu P, Groner B, Wildey G, Dowlati A. Abstract Purpose: Deregulation of STAT3 activation is a hallmark of many cancer cells and the underlying mechanisms are subject to intense investigation. We examined the extent of PIAS3…
Read MoreGamma knife radiosurgery of brain metastasis from malignant pleural mesothelioma–report of three cases with autopsy study in a case
Nagoya Journal of Medical Science. 2014 February. [Link] Kobayashi T, Tsugawa T, Hashizume C, Toriyama T, Asai M, Mori Y, Shibamoto Y. Abstract The median survival time of malignant pleural mesothelioma (MPM) has been 9 months. Given the short survival, there have been only few cases in which brain metastases have been diagnosed and treated…
Read MoreRat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis
Nagoya Journal of Medical Science. 2014 February [Epub ahead of print] [Link] Aierken D, Okazaki Y, Chew SH, Sakai A, Wang Y, Nagai H, Misawa N, Kohyama N, Toyokuni S. Abstract Asbestos was abundantly used in industry during the last century. Currently, asbestos confers a heavy social burden due to an increasing number of patients…
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