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Cytoreductive Surgery and HIPEC for Malignant Peritoneal Mesothelioma: Outcomes and Survival From an Australian Centre
Anticancer Research 2022 June [Link] Raphael Shamavonian, Ernest Cheng, Josh B Karpes, Shoma Barat, Nima Ahmadi, David L Morris Abstract Background/aim: The aim of the study was to determine outcomes and overall survival (OS) in patients undergoing cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) for malignant peritoneal mesothelioma (MPM). Patients and methods: This was…
Read MoreA Drug Screening Revealed Novel Potential Agents against Malignant Pleural Mesothelioma
Cancers 2022 May 20 [Link] Irene Dell’Anno, Alessandra Melani, Sarah A Martin, Marcella Barbarino, Roberto Silvestri, Monica Cipollini, Antonio Giordano, Luciano Mutti, Andrea Nicolini, Luca Luzzi, Raffaele Aiello, Federica Gemignani, Stefano Landi Abstract The lack of effective therapies remains one of the main challenges for malignant pleural mesothelioma (MPM). In this perspective, drug repositioning could…
Read MoreEpithelioid Pleural Mesothelioma Is Characterized by Tertiary Lymphoid Structures in Long Survivors: Results from the MATCH Study
International Journal of Molecular Sciences 2022 May 21 [Link] Laura Mannarino, Lara Paracchini, Federica Pezzuto, Gheorghe Emilian Olteanu, Laura Moracci, Luca Vedovelli, Irene De Simone, Cristina Bosetti, Monica Lupi, Rosy Amodeo, Alessia Inglesi, Maurizio Callari, Serena Penpa, Roberta Libener, Sara Delfanti, Antonina De Angelis, Alberto Muzio, Paolo Andrea Zucali, Paola Allavena, Giovanni Luca Ceresoli, Sergio…
Read MoreAssociation between thoracic epidural block and major complications after pleurectomy/decortication for malignant pleural mesothelioma under general anesthesia
Regional Anesthesia and Pain Medicine 2022 May 20 [Link] Ken Onoe, Hiroki Ogata, Takuma Okamoto, Hiroai Okutani, Ryusuke Ueki, Nobutaka Kariya, Tsuneo Tatara, Masaki Hashimoto, Seiki Hasegawa, Yuka Matsuki, Munetaka Hirose Abstract Introduction: A curative-intent surgical procedure, pleurectomy/decortication, for malignant pleural mesothelioma is accompanied by a high incidence of major postoperative complications. Although epidural block,…
Read MoreHeadspace Volatile Organic Compound Profiling of Pleural Mesothelioma and Lung Cancer Cell Lines as Translational Bridge for Breath Research
Frontiers in Oncology 2022 May 6 [Link] Eline Janssens, Zoë Mol, Lore Vandermeersch, Sabrina Lagniau, Karim Y Vermaelen, Jan P van Meerbeeck, Christophe Walgraeve, Elly Marcq, Kevin Lamote Abstract Introduction: Malignant pleural mesothelioma (MPM) is a lethal cancer for which early-stage diagnosis remains a major challenge. Volatile organic compounds (VOCs) in breath proved to be…
Read MoreEffects of inhalable gene transfection as a novel gene therapy for non-small cell lung cancer and malignant pleural mesothelioma
Scientific Reports 2022 May 23 [Link] Misa Ichikawa, Naomi Muramatsu, Wataru Matsunaga, Takahiro Ishikawa, Tomoyuki Okuda, Hirokazu Okamoto, Akinobu Gotoh Abstract Gene therapy using vectors has attracted attention in recent years for the treatment of cancers caused by gene mutations. Besides, new treatments are imperative for lung cancer, including non-small cell lung cancer (NSCLC) and…
Read MoreUpdate of pathological diagnosis of pleural mesothelioma using genomic-based morphological techniques, for both histological and cytological investigations
Pathology International 2022 May 21 [Link] Kazuki Nabeshima, Makoto Hamasaki, Yoshiaki Kinoshita, Shinji Matsumoto, Prakasit Sa-Ngiamwibool Abstract As more than 80% of pleural mesothelioma (PM) cases start with pleural effusions, diagnosis with effusion smear cytology or pleural biopsy is important. For diagnosing PM, a three-step approach is used: (1) detecting atypical cells; (2) verifying their…
Read MoreEZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study
The Lancet Oncology 2022 May 16 [Link] Marjorie G Zauderer, Peter W Szlosarek, Sylvestre Le Moulec, Sanjay Popat, Paul Taylor, David Planchard, Arnaud Scherpereel, Marianna Koczywas, Martin Forster, Robert B Cameron, Tobias Peikert, Evren Kocabaş Argon, Neil R Michaud, Attila Szanto, Jay Yang, Yingxue Chen, Vikram Kansra, Shefali Agarwal, Dean A Fennell Abstract Background: Treatment…
Read MoreTwo-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats
Particle and Fibre Toxicology 2022 May 19 [Link] Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, Satoshi Yokota, Norihiro Kobayashi, Makoto Ohnishi, Yuko Goto, Takamasa Numano, Hiroyuki Tsuda, David B Alexander, Jun Kanno, Akihiko Hirose, Akiko Inomata, Dai Nakae Abstract Background: A mounting…
Read MoreA Canadian single-centre experience with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for abdominal malignancies
Canadian Journal of Surgery 2022 May 17 [Link] Rami Nassabein, Rami Younan, Rasmy Loungarath, Frederic Mercier, Francois Dagbert, Francine Aubin, Jean Pierre Ayoub, Mustapha Tehfé Abstract Background: Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has recently shown promise for the treatment of patients with various types of peritoneal carcinomatosis (PC). However, it is…
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