MesotheliomaCenter's

Mesothelioma-Line

Curated Journal Articles on Mesothelioma

Category Archives: Type of Mesothelioma:

Loaction of the turmors and cell characteristics are among the differientiating factors in mesothelioma.

Dysregulated expression of the microRNA miR-137 and its target YB-1 contribute to the invasive characteristics of malignant pleural mesothelioma

Journal of Thoracic Oncology 2017 November 4 [Epub ahead of print] [Link] Johnson TG, et. al., Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterised by frequent chromosomal deletions of tumour suppressors, including microRNAs. MiR-137 plays a tumour suppressor role in other cancers, […]

Comments Off on Dysregulated expression of the microRNA miR-137 and its target YB-1 contribute to the invasive characteristics of malignant pleural mesothelioma

4EGI-1 represses cap-dependent translation and regulates genome-wide translation in malignant pleural mesothelioma

Investigational New Drugs 2017 November 8 [Epub ahead of print] [Link] Link De A, Jacobson BA, Peterson MS, Jay-Dixon J, Kratzke MG, Sadiq AA, Patel MR, Kratzke RA Abstract Deregulation of cap-dependent translation has been implicated in the malignant transformation of numerous human tissues. 4EGI-1, a novel small-molecule inhibitor of cap-dependent translation, disrupts formation of […]

Comments Off on 4EGI-1 represses cap-dependent translation and regulates genome-wide translation in malignant pleural mesothelioma

Cytological Profile of a Case of Malignant Mesothelioma of Pleura with Supraclavicular Lymph Node Metastasis

Journal of Cytology 2017 October-December [Link] Priya PV, Deepa S, Jayalakshmy PL Abstract Malignant mesothelioma of pleura is a locally aggressive rare neoplasm of mesothelial cells, which produces distant metastasis in advanced stages of its course. It is exceptional for patients to present with metastasis prior to the detection of primary tumor in the pleura. […]

Comments Off on Cytological Profile of a Case of Malignant Mesothelioma of Pleura with Supraclavicular Lymph Node Metastasis

A review of bevacizumab in the treatment of malignant pleural mesothelioma

Future Oncology 2017 September [Epub ahead of print] [Link] Brosseau S, Assoun S, Naltet C, Steinmetz C, Gounant V, Zalcman G Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. Systemic chemotherapy is the primary treatment modality for the majority of patients. VEGF plays a key mitogen for MPM cells physiopathology. Bevacizumab, […]

Comments Off on A review of bevacizumab in the treatment of malignant pleural mesothelioma

Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1

Oncotarget 2017 September [Link] Eguchi T, Kadota K, Mayor M, Zauderer MG, Rimner A, Rusch VW, Travis WD, Sadelain M, Adusumilli PS Abstract BACKGROUND: To develop cancer antigen-targeted immunotherapeutic strategies for malignant pleural mesothelioma (MPM), we investigated the individual and coexpressions of the cancer-associated antigens mesothelin (MSLN), cancer antigen 125 (CA125), and Wilms tumor 1 […]

Comments Off on Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1

Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

Oncotarget 2017 August [Link] Birnie KA, Prêle CM, Thompson PJ, Badrian B, Mutsaers S Abstract Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced […]

Comments Off on Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

PD-L1 expression associated with worse survival outcome in malignant pleural mesothelioma

Asia-Pacific Journal of Clinical Oncology 2017 November [Epub ahead of print] [Link] Nguyen BH, Montgomery R, Fadia M, Wang J, Ali S Abstract AIM: There is currently a need to identify prognostic biomarkers to assist in a risk adopted approach in treatment of malignant pleural mesothelioma (MPM). Expression of programmed death ligand 1 (PD-L1) has […]

Comments Off on PD-L1 expression associated with worse survival outcome in malignant pleural mesothelioma

Chimeric antigen receptor (CAR) T-cell therapy for thoracic malignancies

Journal of Thoracic Oncology 2017 October [Epub ahead of print] [Link] Kiesgen S, Chicaybam L, Chintala NK, Adusumilli PS Abstract Chimeric antigen receptor (CAR) T cells are patient T cells that are transduced with genetically engineered synthetic receptors to target a cancer cell surface antigen. The remarkable clinical response rates achieved by adoptive transfer of […]

Comments Off on Chimeric antigen receptor (CAR) T-cell therapy for thoracic malignancies

Chemical profiling of primary mesothelioma cultures defines subtypes with different expression profiles and clinical responses

Clinical Cancer Research 2017 October [Epub ahead of print] [Link] Schunselaar L1, Quispel-Janssen JM2, Kim Y3, Alifrangis C4, Zwart W5, Baas P6, Neefjes J Abstract Finding new treatment options for patients with malignant pleural mesothelioma is challenging due to the rarity and heterogeneity of this cancer type. The absence of druggable targets further complicates the […]

Comments Off on Chemical profiling of primary mesothelioma cultures defines subtypes with different expression profiles and clinical responses

Epidemiology of malignant peritoneal mesothelioma: A population-based study

Cancer Epidemiology 2017 October [Epub ahead of print] [Link] Salo SAS, Ilonen I, Laaksonen S, Myllärniemi M, Salo JA, Rantanen T Abstract BACKGROUND: Malignant peritoneal mesothelioma (MPeM) is a rare cancer of the mesothelial cells in the peritoneum with poor prognosis. Earlier reports from other countries indicate an incidence of 0.2-3 new cases per million […]

Comments Off on Epidemiology of malignant peritoneal mesothelioma: A population-based study