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Curated Journal Articles on Mesothelioma

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Loaction of the turmors and cell characteristics are among the differientiating factors in mesothelioma.

PD-1 blockade with nivolumab in patients with recurrent Malignant Pleural Mesothelioma

Journal of Thoracic Oncology 2018 June 13 [Link] Quispel-Janssen J, van der Noort V, de Vries JF, Zimmerman M, Lalezari F, Thunnissen E, Monkhorst K, Schouten R, Schunselaar L, Disselhorst M, Klomp H, Hartemink K, Burgers S, Buikhuisen W, Baas P Abstract BACKGROUND: Malignant Pleural Mesothelioma (MPM) has limited treatment options and a poor outcome. […]

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Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas.

Journal of Cellular Physiology 2018 June 15 [Link] Sementino E, Menges CW, Kadariya Y, Peri S, Xu J, Liu Z, Wilkes RG, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Abstract Malignant mesothelioma (MM) is a therapy-resistant cancer arising primarily from the lining of the pleural and peritoneal cavities. The most frequently altered genes in human MM […]

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Heat shock protein 90 inhibitors augment endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity.

Oncotarget 2018 May 26 [Link] Chai K, Ning X, Nguyễn TTT, Zhong B, Morinaga T, Li Z, Shingyoji M, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Yamaguchi N, Tagawa M Abstract Heat shock protein 90 (HSP90) inhibitors suppressed MDM4 functions which mediated p53 ubiquitination, and blocked a chaperon function which influenced expression of the […]

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Integrated Histogenetic Analysis Reveals BAP1-Mutated Epithelioid Mesothelioma in a Patient With Cancer of Unknown Primary.

Journal of the National Comprehensive Cancer Network 2018 June 16 [Link] Bochtler T, Endris V, Reiling A, Leichsenring J, Schweiger MR, Klein S, Stögbauer F, Goeppert B, Schirmacher P, Krämer A, Stenzinger A Abstract This case report presents a male patient with epithelioid mesothelioma that was initially misdiagnosed as cancer of unknown primary (CUP) and […]

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Aquaporin-1 (AQP-1) expression in fluoro-edenite-induced mesothelioma effusions: an approach by cell-block procedure

Cytopathology 2018 June 6 [Link] Angelico G, Ieni A, Caltabiano R, Zeppa P, Tuccari G Abstract OBJECTIVE: Aquaporin 1 (AQP-1) is a water channel protein found in cell membranes, whose expression has been considered an independent favourable prognostic factor in pleural Malignant Mesothelioma (MM). The aim of this study is to evaluate the expression of […]

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Air in the Pleural Cavity Enhances Detection of Pleural Abnormalities by CT Scan

Chest 2018 June [Link] Fysh ETH, Thomas R, Tobin C, Kuok YJ, Lee YCG Abstract Detection of pleural abnormalities on CT scan is critical in diagnosis of pleural disease. CT scan detects minute parenchymal lung nodules, but often fails to detect similar-sized pleural nodularity. This is likely because the density of the visceral/parietal pleura and […]

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Peritoneal Metastases from Gastrointestinal Cancer

Current Oncology Reports 2018 June 8 [Link] Sugarbaker PH Abstract PURPOSE OF REVIEW: Peritoneal metastases may occur from a majority of cancers that occur within the abdomen or pelvis. When cancer spread to the peritoneal surfaces is documented, a decision regarding palliation vs. an aggressive approach using cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy must […]

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Proton beam therapy for malignant pleural mesothelioma.

Translational Lung Cancer Research 2018 April 7 [Link] Badiyan SN, Molitoris JK, Zhu M, Glass E, Diwanji T, Simone CB Abstract Malignant pleural mesothelioma (MPM) is a rare disease with a poor prognosis. Surgical techniques have made incremental improvements over the last few decades while new systemic therapies, including immunotherapies, show promise as potentially effective […]

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FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients.

European Journal of Nuclear Medicine and Molecular Imaging 2018 June 6 [Link] Incerti E, Broggi S, Fodor A, Cuzzocrea M, Samanes Gajate AM, Mapelli P, Fiorino C, Dell’Oca I, Pasetti M, Cattaneo M, Calandrino R, Gianolli L, Di Muzio N, Abstract PURPOSE: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free […]

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A Phase II Trial of First-Line Combination Chemotherapy With Cisplatin, Pemetrexed, and Nivolumab for Unresectable Malignant Pleural Mesothelioma: A Study Protocol.

Clinical Lung Cancer 2018 May 9 [Link] Fujimoto N, Aoe K, Kozuki T, Oze I, Kato K, Kishimoto T, Hotta K

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