Nanotubes, Nanofibers
Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks
Biomolecules 2022 June 27 [Link] Swaroop Kumar Pandey, Renen Machlof-Cohen, Manikandan Santhanam, Anna Shteinfer-Kuzmine, Varda Shoshan-Barmatz Abstract Mesothelioma, an aggressive cancer with a poor prognosis, is linked to asbestos exposure. However, carbon nanotubes found in materials we are exposed to daily can cause mesothelioma cancer. Cancer cells reprogram their metabolism to support increased biosynthetic and…
Read MoreAsbestos-induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species
Pathology International 2021 December 29 [Link] Yasumasa Okazaki Abstract Asbestos fibers have been used as an industrial and construction material worldwide due to their high durability and low production cost. Commercial usage of asbestos is currently prohibited in Japan; however, the risk of asbestos-induced malignant mesothelioma (MM) remains. According to epidemiological data, the onset of…
Read MoreFour Immune-Related Genes (FN1, UGCG, CHPF2 and THBS2) as Potential Diagnostic and Prognostic Biomarkers for Carbon Nanotube-Induced Mesothelioma
International Journal of General Medicine 2021 August 29 [Link] Dongli Xie, Jianchen Hu, Tong Wu, Kangli Cao, Xiaogang Luo Abstract Background: Malignant pleural mesothelioma (MPM), a highly aggressive cancer, was mainly attributed to asbestos exposure. Carbon nanotubes (CNTs) share similar negative features to asbestos, provoking concerns about their contribution to MPM. This study was used…
Read MoreRole of Inflammation in the Malignant Transformation of Pleural Mesothelial Cells Induced by Multi-Walled Carbon Nanotubes
Nanotoxicology 2020 June 23 [Link] Xiaopei Huang, Yijun Tian, Wenjing Shi, Jikuai Chen, Lang Yan, Lijun Ren, Xiaofang Zhang, Jiangbo Zhu Abstract Multi-walled carbon nanotubes (MWCNTs) are one of the most widely used types of novel nano-fiber materials. The aim of this study was to establish an experimental system based on actual exposure dosage and…
Read MoreAsbestos fiber length and its relation to disease risk
Inhalation Toxicology 2017 Oct to December [Link] Barlow CA, Grespin M, Best EA Abstract Differences in chemical and crystalline composition, fiber dimension, aerodynamic characteristics and biodurability are among the critical factors that define the toxicological and pathological consequences of asbestos exposure. Specifically, fiber dimension can impact whether the fiber is respired, whether and how deeply…
Read MoreAsbestos fibre burden in gallbladder: A case study
Micron 2017 Dec 8 [Epub ahead of print] [Link] Croce A, Capella S, Belluso E, Grosso F, Mariani N, Libener R, Rinaudo C Abstract The methods conventionally used to determine the burden of asbestos fibres inhaled/incorporated in lung require chemical digestion of the biological matrix before counting/characterising the inorganic fibrous phases under scanning electron microscopy…
Read MoreThe asbestos fibre burden in human lungs: new insights into the chrysotile debate
European Respiratory Journal 2017 [Link] Feder IS, Tischoff I, Theile A, Schmitz I, Merget R, Tannapfel A Abstract The traceability of asbestos fibres in human lungs is a matter of discussion especially for chrysotile. This issue is of high significance for differential diagnosis, risk assessment and occupational compensation. At present no intra-individual longitudinal information is…
Read MoreGeographic and socioeconomic factors in patients with malignant pleural mesothelioma in New South Wales and their impact upon clinical outcomes
Respirology 2017 January 31 [Epub ahead of print] [Link] Linton A, Soeberg M, Broome R, Kao S, van Zandwijk N Abstract BACKGROUND AND OBJECTIVE: Whilst the impact of clinicopathological factors on the prognosis of malignant pleural mesothelioma (MPM) is well understood, socioeconomic and geographic factors have received less attention. We analysed the relationship between geographic…
Read MoreMalignant pleural mesothelioma: an update on investigation, diagnosis and treatment
European Respiratory Review 2016 December [Link] Bibby AC, Tsim S, Kanellakis N, Ball H, Talbot DC, Blyth KG, Maskell NA, Psallidas Abstract Malignant pleural mesothelioma is an aggressive malignancy of the pleural surface, predominantly caused by prior asbestos exposure. There is a global epidemic of malignant pleural mesothelioma underway, and incidence rates are predicted to…
Read MoreAsbestos exposure and histological subtype of malignant mesothelioma
Occupational and Environmental Medicine 2016 November [Epub 2016 August 19] [Link] Franklin P, Alfonso H, Reid A, Olsen N, Shilkin KB, Brims F, de Klerk N, Musk AW Abstract BACKGROUND: Malignant mesothelioma (MM) has distinct histological subtypes (epithelioid, sarcomatoid and biphasic) with variable behaviour and prognoses. It is well recognised that survival time varies with…
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