Diffuse mesothelioma
Comprehensive epithelial biomarker analysis of malignant mesothelioma: EpCAM positivity is a potential diagnostic pitfall
Cancer Cytopathology 2023 April 17 [Link] Yili Zhu, Simone Moore, Aihui Wang, Elizabeth George, Grace M Allard, Diane M Libert, Alarice C Lowe Abstract Background: Epithelial cell adhesion molecule (EpCAM) is frequently used to distinguish carcinoma from background mesothelial cells during cytologic examination of body cavity fluids. Previously, the authors identified one malignant mesothelioma case…
Read MoreSurgical case report: The rare case of incidental retroperitoneal mesothelioma
International Journal of Surgery Case Reports 2023 April [Link] Yat Cheung Chung, Travis Ackermann, Yeu Sheng Ang Abstract Introduction and importance: This is a first reported case of isolated retroperitoneal mesothelioma. Most patients present with symptoms of abdominal pain, distension and weight loss. However, a minority of cases are asymptomatic and are found incidentally on…
Read MoreLong-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma
Case Reports in Medicine 2023 February 28 [Link] Yasuo Otsuka, Yoriaki Komeda, Masayuki Takeda, Takayuki Takahama, Masashi Kono, Mamoru Takenaka, Satoru Hagiwara, Naoshi Nishida, Hiroshi Kashida, Masatoshi Kudo Abstract A 76-year-old woman presented with lower abdominal pain and nausea and was referred to the gastroenterology department in our institution. Previous contrast-enhanced computed tomography (CE-CT) for…
Read MoreMesothelioma In Situ Mimicking Well-differentiated Papillary Mesothelial Tumor
The American Journal of Surgical Pathology 2023 March 6 [Link] Francoise Galateau-Salle, Trevor Hamilton, Andrea MacNeill, Véronique Hofman, Ruth Sequeiros, Christine Sagan, Nolwenn Le Stang, Andrew Churg Abstract We have previously hypothesized that well-differentiated papillary mesothelial tumor (WDPMT) consists of 2 morphologically identical lesions, one of which is true WDPMT, while the other is a…
Read MoreA novel prognostic nomogram for predicting survival in diffuse pleural mesothelioma
Pathology 2023 February 4 [Link] Yagiz Aksoy, Angela Chou, Mahiar Mahjoub, Amy Sheen, Loretta Sioson, Mahsa S Ahadi, Anthony J Gill, Talia L Fuchs Abstract Recent advances in the management of diffuse pleural mesothelioma (DPM) have increased interest in prognostication and risk stratification on the basis that maximum benefit of combination immunotherapy appears to be…
Read MoreNeurofibromatosis Type 2-Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif Dual Immunohistochemistry Is a Reliable Marker for the Detection of Neurofibromatosis Type 2 Alterations in Diffuse Pleural Mesothelioma
Modern Pathology 2023 March [Link] Yan Li, Soo-Ryum Yang, Ying-Bei Chen, Prasad S Adusumilli, Ann Bialik, Francis M Bodd, Marc Ladanyi, Jessica Lopardo, Michael D Offin, Valerie W Rusch, William D Travis, Marjorie G Zauderer, Jason C Chang, Jennifer L Sauter Abstract Neurofibromatosis type 2 (NF2) loss occurs in approximately 30% to 50% of diffuse…
Read MoreNR4A3 fusions characterize a distinctive peritoneal mesothelial neoplasm of uncertain biological potential with pure adenomatoid/microcystic morphology
Genes, Chromosomes, and Cancer 2022 December 16 [Link] Abbas Agaimy, Luka Brcic, Laurence M Briski, Yin P Hung, Michael Michal, Michal Michal, G Petur Nielsen, Robert Stoehr, Andrew E Rosenberg Abstract A focal adenomatoid-microcystic pattern is not uncommon in peritoneal mesothelioma, but tumors composed almost exclusively of this pattern are distinctly rare and have not…
Read MoreMedical and surgical care of mesothelioma patients and their relatives carrying germline BAP1 mutations
Journal of Thoracic Oncology 2022 April 21 [Link] Michele Carbone, Harvey I Pass, Guntulu Ak, H Richard Alexander Jr, Paul Baas, Francine Baumann, Andrew M Blakely, Raphael Bueno, Aleksandra Bzura, Giuseppe Cardillo, Jane E Churpek, Irma Dianzani, Assunta De Rienzo, Mitsuru Emi, Salih Emri, Emanuela Felley-Bosco, Dean A Fennell, Raja M Flores, Federica Grosso, Nicholas…
Read MoreMulticenter study of diffuse pleural mesothelioma. Histopathological and immunohistochemical features
Medicina 2022 [Link] Claudia Poleri, Gabriela Acosta Haab, Nora Falcoff, Gabriela Guman, Liliana Dalurzo, Alejandro Iotti, María Eugenia Martín, Gloria Olmedo, Mercedes Rayá, Atilio Reginatto, Andrea Werbach, Gabriela Demelli, María José Labanca, Laura Leguina, María Florencia Mora Abstract The pathological diagnosis of diffuse pleural mesothelioma (DPM) contributes to treatment selection and clinical trials interpretation. To…
Read MoreA Critical Assessment of Current Grading Schemes for Diffuse Pleural Mesothelioma With a Proposal for a Novel Mesothelioma Weighted Grading Scheme (MWGS)
The American Journal of Surgical Pathology 2021 December 15 [Link] Talia L Fuchs, Angela Chou, Yagiz Aksoy, Mahiar Mahjoub, Amy Sheen, Loretta Sioson, Mahsa Ahadi, Anthony J Gill Abstract Although there is early support for schemes based on nuclear grade, necrosis and mitotic rate, there is currently no widely implemented grading system for diffuse pleural…
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