Salvage debulking surgery and hyperthermic intrathoracic chemotherapy for massive recurrent mesothelioma in the mediastinum

Interactive Cardiovascular and Thoracic Surgery 2022 February 26 [Link] Shi Sum Poon, Caterina Alberti, Marco Nardini, Marcello Migliore Abstract Mediastinal malignant pleural mesothelioma with signs of tamponade is rare. Indication for reoperation for recurrent malignant pleural mesothelioma is a controversial but viable option in selected patients. We report a case of a 68-year-old man presenting…

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Surgical strategy for malignant pleural mesothelioma: the superiority of pleurectomy/decortication

Surgery Today 2022 January 19 [Link] Masatoshi Kanayama, Masataka Mori, Hiroki Matsumiya, Akihiro Taira, Shinji Shinohara, Masaru Takenaka, Koji Kuroda, Fumihiro Tanaka Abstract Purpose: Both extrapleural pneumonectomy (EPP) and pleurectomy/decortication (P/D) are used for the surgical treatment of malignant pleural mesothelioma (MPM). This study aimed to compare the operative and clinical outcomes and survival between…

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Long-term outcomes after lung-sparing surgery for epithelial mesothelioma

Journal of Thoracic Disease 2021 November [Link] Cristiano Breda, Simone Furia, Giuseppe Lucchini, Antonio Zaccaria, Enrico Verderi, Giuseppe Natale, Fabio Lo Giudice, Roberta Cavallin, Andrea Ferronato, Paolo Fontana Abstract Background: This observational study evaluates retrospectively the long-term outcomes after pleurectomy/decortication for pleural mesothelioma, with and without the resection/reconstruction of diaphragm and pericardium. Methods: Data from…

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Quality of Life Is Not Deteriorated After Extrapleural Pneumonectomy vs. (Extended) Pleurectomy/Decortication in Patients With Malignant Pleural Mesothelioma

Frontiers in Surgery 2021 December 8 [Link] Olivia Lauk, Miriam Patella, Thomas Neuer, Ilhan Inci, Walter Weder, Isabelle Opitz Abstract Background: Extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM) is highly abandoned due to high morbidity and mortality rates and impaired quality of life (QoL). However, there are still rare indications for this intervention. The…

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Efficacy of Intraoperative Hypertonic Glucose Solution Administration on Persistent Air Leak After Extended Pleurectomy/Decortication for Malignant Pleural Mesothelioma: A Retrospective Case-Control Study

Frontiers in Oncology 2021 December 1 [Link] Alberto Testori, Gianluca Perroni, Marco Alloisio, Emanuele Voulaz, Veronica Maria Giudici, Umberto Cariboni, Edoardo Bottoni Abstract Background: Persistent air leak is a common complication occurring from 6% to 23% of cases after extended pleurectomy/decortication for malignant pleural mesothelioma. Treatment options for this complication after major lung resection are…

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Immunotherapy, the promise for present and future of malignant pleural mesothelioma (MPM) treatment

Therapeutic Advances In Medical Oncology 2021 December 10 [Link] Valérie Gounant, Solenn Brosseau, Gérard Zalcman Abstract Due to occupational asbestosis exposure, the incidence of malignant pleural mesothelioma (MPM) has continuously increased over the last 30 years, with a plateau anticipated around the year 2030 in Western countries. Molecular MPM carcinogenesis involves alterations of NF2, RASSF1,…

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Postoperative empyema after pleurectomy decortication for malignant pleural mesothelioma

Annals of Thoracic Surgery 2021 October 4 [Link] Moshe Lapidot, Emanuele Mazzola, Samuel Freyaldenhoven, Luis E De León, Michael T Jaklitsch, Raphael Bueno Abstract Background: Postoperative empyema following pleurectomy decortication (PDC) for malignant pleural mesothelioma (MPM) is a serious complication that necessitates prolonged hospitalization. The aim of this study was to determine the incidence, risk…

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Hyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies-A Retrospective, Multicentre Study

Cancers 2021 September 12 [Link] Michael Ried, Julia Kovács, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hauke Winter, Laura V Klotz, Rudolf Hatz, Julia Zimmermann, Bernward Passlick, Severin Schmid, Mohamed Hassan, Martin E Eichhorn, Hans-Stefan Hofmann Abstract In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity…

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Hyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies-A Retrospective, Multicentre Study

Cancers 2021 September 12 [Link] Michael Ried, Julia Kovács, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hauke Winter, Laura V Klotz, Rudolf Hatz, Julia Zimmermann, Bernward Passlick, Severin Schmid, Mohamed Hassan, Martin E Eichhorn, Hans-Stefan Hofmann Abstract In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity…

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GOECP/SEOR clinical guidelines on radiotherapy for malignant pleural mesothelioma

World Journal of Clinical Oncology 2021 August 24 [Link] Javier Luna, Andrea Bobo, Joaquín José Cabrera-Rodriguez, María Pagola, Margarita Martín-Martín, María Ángeles González Ruiz, Miguel Montijano, Aurora Rodríguez, Lira Pelari-Mici, Almudena Corbacho, Marta Moreno, Felipe Couñago Abstract Malignant pleural mesothelioma (MPM) is a rare tumor with poor prognosis and rising incidence. Palliative care is common…

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