Gene Therapy
Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma.
Oncoimmunology 2017 January [Link] Kiyotani K, Park JH, Inoue H, Husain A, Olugbile S, Zewde M, Nakamura Y, Vigneswaran WT Abstract To investigate the link between the genomic landscape of cancer cells and immune microenvironment in tumor tissues, we characterized somatic mutations and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM), including mutation/neoantigen load, spatial…
Read MoreReduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir
Toxicology In Vitro Journal 2017 February [Epub ahead of print] [Link] Catalani S, Palma F, Battistelli S, Nuvoli B, Galati R, Benedetti S Abstract Besides its well-recognized antiviral activity, Cidofovir (CDV) has been shown to exert anticancer properties both within in vitro and in vivo models. The aim of this study was to evaluate the…
Read MoreKdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma
International Journal of Oncology 2017 February 9 [Epub ahead of print] [Link] Cregan S, Breslin M, Roche G, Wennstedt S, MacDonagh L, Albadri C, Gao Y, O’Byrne KJ, Cuffe S, Finn SP, Gray SG Abstract Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The…
Read MoreIdentification of MiR-21-5p as a Functional Regulator of Mesothelin Expression Using MicroRNA Capture Affinity Coupled with Next Generation Sequencing
PLoS One 2017 January 26 [
Read MorePromising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts
International Journal of Cancer 2017 January [Epub 2016 September 19] [Link] Vázquez R, Licandro SA, Astorgues-Xerri L, Lettera E, Panini N, Romano M, Erba E, Ubezio P, Bello E, Libener R, Orecchia S, Grosso F, Riveiro ME, Cvitkovic E, Bekradda M, D’Incalci M, Frapolli R Abstract It has recently been reported that a large proportion…
Read MoreIntrapleural Adenoviral-mediated Endothelial Cell Protein C Receptor Gene Transfer Suppresses the Progression of Malignant Pleural Mesothelioma in a Mouse Model
Scientific Reports 2016 November 11 [Link] Keshava S, Rao LV, Pendurthi UR Abstract Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer with a high mortality rate as it responds poorly to standard therapeutic interventions. Our recent studies showed that expression of endothelial cell protein C receptor (EPCR) in MPM cells suppresses tumorigenicity. The present…
Read MoreMalignant pleural mesothelioma and mesothelial hyperplasia: A new molecular tool for the differential diagnosis
Oncotarget 2016 November 7 [Epub ahead of print] [Link] Bruno R, Alì G, Giannini R, Proietti A, Lucchi M, Chella A, Melfi F, Mussi A, Fontanini G Abstract Malignant pleural mesothelioma (MPM) is a rare asbestos related cancer, aggressive and unresponsive to therapies. Histological examination of pleural lesions is the gold standard of MPM diagnosis,…
Read MoreSORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma
International Journal of Oncology 2016 November 10 [Epub ahead of print] [Link] Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu HP, Ujiie H, Kaji M, Kano S, Matsuge S, Domen H, Kanno H, Hatanaka Y, Hatanaka KC, Kaga K, Matsui Y, Matsuno Y, De Perrot M, Yasufuku K Abstract Malignant…
Read MoreMyxoid variant epithelioid pleural mesothelioma defines a favourable prognosis group: an analysis of 191 patients with pleural malignant mesothelioma
Journal of Clinical Pathology 2016 October 18 [Epub ahead of print] [Link] Alchami FS1, Attanoos RL1, Bamber AR Abstract Malignant pleural mesothelioma shows marked cytoarchitectural diversity. The aim of the study was to evaluate how morphological phenotype impacted upon overall survival. 191 cases of malignant pleural mesothelioma with available follow-up were identified, examined and classified…
Read MoreVEGF promoter-based conditionally replicative adenoviruses effectively suppress growth of malignant pleural mesothelioma
Cancer Science 2016 October 26 [Epub ahead of print] [Link] Harada A, Uchino J, Harada T, Nakagaki N, Hisasue J, Fujita M, Takayama K Abstract Malignant mesothelioma (MM) incidence is increasing drastically worldwide as an occupational disease resulting from asbestos exposure. However, no curative treatment for MM of advanced stage is available. Thus, new therapeutic…
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