EGFR
Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement
Cancer Letters. 2008 Mar 23 [Epub ahead of print] [Link] Ogino H, Yano S, Kakiuchi S, Yamada T, Ikuta K, Nakataki E, Goto H, Hanibuchi M, Nishioka Y, Ryan A, Sone S. Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. Abstract Malignant…
Read MoreEGFR And PDGFR Differentially Promote Growth In Malignant Epitheloid Mesothelioma Of Short- And Long-term Survivors
Thorax. 2007 Dec 17 [Epub ahead of print] [Link] Kothmaier H, Quehenberger F, Halbwedl I, Morbini P, Demirag F, Zeren H, Comin CE, Murer B, Cagle PT, Attanoos R, Gibbs AR, Gallateau-Salle F, Popper HH. Institute of Pathology, Medical University of Graz, Austria. Abstract Malignant pleural mesothelioma (MPM) is an asbestos-related tumour difficult to detect…
Read MoreReactivity of integrin-linked kinase in human mesothelial cell proliferation
Interactive CardioVascular and Thoracic Surgery. 2007 Nov 29 [Epub ahead of print] [Link] Watzka SB, Setinek U, Huber M, Cantonati H, Lax F, Watson S, Weigel G, Mueller MR. Otto Wagner Hospital, Vienna, Austria. Abstract Integrin-linked kinase (ILK) is a protein kinase that links integrins and growth factors to a range of signalling pathways. ILK…
Read MoreImmunohistochemical expression and distribution of VEGFR-3 in malignant mesothelioma
Diagnostic Cytopathology. 2007 Dec;35(12):786-91. [Link] Filho AL, Baltazar F, Bedrossian C, Michael C, Schmitt FC. Life and Health Sciences Research Institute, Health Sciences School, University of Minho, Braga, Portugal. Abstract Homogeneity of mesothelial and lymphatic endothelial cells, express some markers that are presumed to be exclusive of the endothelium was recently reported. This similarity is…
Read MoreThe Therapeutic Efficacy of Anti–Vascular Endothelial Growth Factor Antibody, Bevacizumab, and Pemetrexed against Orthotopically Implanted Human Pleural Mesothelioma Cells in Severe Combined Immunodeficient Mice
Clinical Cancer Research. 13, 5918-5925, October 1, 2007. [Link] Li Q, Yano S, Ogino H, Wang W, Uehara H, Nishioka Y, Sone S. Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima Graduate School, Tokushima, Japan Abstract Purpose: Malignant pleural mesothelioma (MPM) is an aggressive malignancy, which has a poor prognosis with a…
Read MoreOcular toxicities of epidermal growth factor receptor inhibitors and their management
Cancer Nursing. 30(4) Supplement 1:S10-S16, July/August 2007. [Link] Basti S. Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA. sbasti@northwestern.edu Abstract Epidermal growth factor receptor (EGFR) inhibitors have become an important therapy for patients with malignant solid tumors, such as non-small cell lung, breast, ovarian, colorectal, renal, esophageal, sarcoma, mesothelioma, prostate, head…
Read MorePhase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study
Journal of Clinical Oncology. 2007 Jul 15;110(2):420-31. [Link] Garland LL, Rankin C, Gandara DR, Rivkin SE, Scott KM, Nagle RB, Klein-Szanto AJ, Testa JR, Altomare DA, Borden EC. University of Arizona Cancer Center, Tucson, AZ, USA. Abstract Purpose:Malignant pleural mesothelioma (MPM) expresses high levels of epidermal growth factor receptor (EGFR), and preclinical studies have identified…
Read MoreOsteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma
Histopathology. Volume 50 Issue 6 Page 720-726, May 2007. [Link] Frey AB, Wali A, Pass H, Lonardo F. Department of Pathology, Harper University Hospital, and Karmanos Cancer Institute, 3990 John R. Street, Detroit, MI 48201, USA. Abstract Aims: Osteopontin (OPN) is a matricellular protein involved in tissue remodelling, cell-mediated immunity and malignant transformation. High OPN…
Read MoreUpdate on the molecular biology of malignant mesothelioma
Cancer. 2007 Apr 15;109(8):1454-61. [Link] Lee AY, Raz DJ, He B, Jablons DM. Department of Surgery, Division of Cardiothoracic Surgery, University of California, San Francisco, California 94143, USA. Abstract Malignant mesothelioma (MM) is a highly aggressive tumor with a very poor prognosis. The disease is largely unresponsive to conventional chemotherapy or radiotherapy, and most patients…
Read MoreEGFR expression: Associations with outcome and clinicopathological variables in malignant pleural mesothelioma
Lung Cancer, Volume 54, Issue 3, Pages 399-407 J.G. Edwardsa,b, D.E.B. Swinsona, J.L. Jonesc, D.A. Wallerb, K.J. O’Byrned a Department of Oncology, University of Leicester, Leicester, United Kingdom b Department of Thoracic Surgery, University Hospitals Leicester NHS Trust, Glenfield Hospital, Leicester, United Kingdom c Institute of Cancer, Barts and The London NHS Trust, Queen Mary’s…
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