Stem-like exhausted CD8 T cells in pleural effusions predict improved survival in non-small cell lung cancer (NSCLC) and mesothelioma

Translational Lung Cancer Research 2024 September 30 [Link] Linda Ye, Heeju Ryu, David Granadier, Long T Nguyen, Yannick Simoni, Ian Dick, Tina Firth, Ebony Rouse, Peter Chiang, Y C Gary Lee, Bruce W Robinson, Jenette Creaney, Evan W Newell, Alec J Redwood Abstract Background: Anti-tumor CD8 T cells are important for immunity but can become…

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Efficacy of First-Line Nivolumab Plus Ipilimumab in Unresectable Pleural Mesothelioma: A Multicenter Real-World Study (ImmunoMeso LATAM)

Clinical Lung Cancer 2024 December [Link] Diego Enrico, Juan Elias Gomez, Danilo Aguirre, Natalia Soledad Tissera, Florencia Tsou, Carmen Pupareli, Delfina Peralta Tanco, Federico Waisberg, Andrés Rodríguez, Manglio Rizzo, Nicolás Minatta, Picon Rafael, Luis Basbus, Lorena Lupinacci, Diego Kaen, Mauro Ramos, Virginia Bluthgen, Nicolas Castagneris, María Pía Coppola, Alejandra Scocimarro, María Florencia Guerra, Aldo Perfetti,…

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Fractionated low-dose radiotherapy primes the tumor microenvironment for immunotherapy in a murine mesothelioma model

Cancer Immunology, Immunotherapy 2025 January 3 [Link] Rebecca A D’Alonzo, Synat Keam, Suki Gill, Pejman Rowshanfarzad, Anna K Nowak, Martin A Ebert, Alistair M Cook Abstract Combination immune checkpoint inhibitors (nivolumab and ipilimumab) are currently a first-line treatment for mesothelioma; however, not all patients respond. The efficacy of treatment is influenced by the tumor microenvironment.…

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Phase I Clinical Trial on Pleural Mesothelioma Using Neoadjuvant Local Administration of Paclitaxel-Loaded Mesenchymal Stromal Cells (PACLIMES Trial): Study Rationale and Design

Cancers 2024 October 4 [Link] Giulia Maria Stella, Daniela Lisini, Paolo Pedrazzoli, Giulia Galli, Chandra Bortolotto, Giulio Melloni, Gioacchino D’Ambrosio, Catherine Klersy, Amelia Grosso, Francesca Paino, Stefano Tomaselli, Laura Saracino, Giulio Alessandri, Augusto Pessina, Elena Grignani, Vittorio Rosti, Angelo Guido Corsico, Patrizia Comoli, Francesco Agustoni Abstract Background and rationale. Pleural mesothelioma (PM) is a rare…

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Impact of T Cell Ratios on Survival in Pleural Mesothelioma: Insights from Tumor Microenvironment Analysis

Cancers 2924 October 8 [Link] Laura V Klotz, Andreas Weigert, Florian Eichhorn, Michael Allgäuer, Thomas Muley, Rajiv Shah, Rajkumar Savai, Martin E Eichhorn, Hauke Winter Abstract Background: Immunotherapy has significantly improved overall survival in patients with pleural mesothelioma, yet this benefit does not extend to those with the epithelioid subtype. Tumor growth is believed to…

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Transfer learning approach in pre-treatment CT images to predict therapeutic response in advanced malignant pleural mesothelioma

Frontiers in Oncology 2024 September 16 [Link] Annarita Fanizzi, Annamaria Catino, Samantha Bove, Maria Colomba Comes, Michele Montrone, Angela Sicolo, Rahel Signorile, Pia Perrotti, Pamela Pizzutilo, Domenico Galetta, Raffaella Massafra Abstract Introduction: Malignant pleural mesothelioma (MPM) is a poor-prognosis disease. Owing to the recent availability of new therapeutic options, there is a need to better…

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Perfusion Strategies for Cytoreductive Surgery With Heated Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma

Journal of Surgical Oncology 2024 September 10 [Link] Claire Drigotas, Alexander W Loftus, John B Ammori, Luke D Rothermel, Richard S Hoehn Abstract Cytoreductive surgery (CRS) with heated intraoperative intraperitoneal chemotherapy (HIPEC) has been shown to improve survival for patients with malignant peritoneal mesothelioma (MPM). Presently, there is no standardized HIPEC protocol with respect to…

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Drug sensitivity tumor cell clusters in malignant peritoneal mesothelioma

Journal of Surgical Oncology 2024 August 25 [Link] Yan-Dong Su, Ru Ma, Yu-Bin Fu, He-Liang Wu, Xin-Li Liang, Yi-Tong Liu, Yang Yu, Zhi-Ran Yang, Yan Li Abstract Background: To explore the most effective adjuvant chemotherapy regimen for malignant peritoneal mesothelioma (MPM) through patient derived tumor-like cell clusters (PTC) drug sensitivity test. Methods: PTC were cultured…

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The Effect of Cuproptosis-Related Proteins on Macrophage Polarization in Mesothelioma is Revealed by scRNA-seq

Biological Trace Element Research 2024 August 23 [Link] Jia-Xin Xu, Li-Jing Ma, Li-Ying Tu, Qi-Sheng Tang, Bian Wu, Li-Hong Jiang Abstract High invasiveness mesothelioma is a malignant tumor of the peritoneum or pleura. The effect of cuproptosis on mesothelioma (MESO) is still unknown, though. The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO)…

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