Diagnosis & Differentiation
Pleural Fluid-to-Blood BNP Ratio May Contribute to Prognosis in Malignant Pleural Mesothelioma
Clinics and Practice 2023 September 13 [Link] Vasiliki Tsolaki, George E Zakynthinos, Sotirios Zarogiannis, Paris Zygoulis, Ioannis Kalomenidis, Rajesh Jagirdar, Ioannis Triantafyllou, Konstantinos I Gourgoulianis, Demosthenes Makris, Epaminondas Zakynthinos Abstract Background: Brain natriuretic peptide (BNP) seems to be produced from malignant mesothelial cells other than cardiomyocytes. We aimed to evaluate whether an increased pleural fluid-to-blood…
Read MorePleural Fluid-to-Blood BNP Ratio May Contribute to Prognosis in Malignant Pleural Mesothelioma
Clinics and Practice 2023 September 13 [Link] Vasiliki Tsolaki, George E Zakynthinos, Sotirios Zarogiannis, Paris Zygoulis, Ioannis Kalomenidis, Rajesh Jagirdar, Ioannis Triantafyllou, Konstantinos I Gourgoulianis, Demosthenes Makris, Epaminondas Zakynthinos Abstract Background: Brain natriuretic peptide (BNP) seems to be produced from malignant mesothelial cells other than cardiomyocytes. We aimed to evaluate whether an increased pleural fluid-to-blood…
Read MoreMelodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma
Pathology, Research and Practice 2023 September 13 [Link] Mai A Abd-Elmawla, Sherif S Abdel Mageed, Tohada M Al-Noshokaty, Mohammed S Elballal, Ahmed I Abulsoud, Shereen Saeid Elshaer, Ahmed A El-Husseiny, Doaa Fathi, Heba M Midan, Nehal I Rizk, Mahmoud A Elrebehy, Ghadir A Sayed, Manar Mohammed El Tabaa, Aya Salman, Osama A Mohammed, Alaa Ashraf,…
Read MoreKrebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma
Lung Cancer 2023 September 7 [Link] Paul Stockhammer, Hannah Baumeister, Till Ploenes, Francesco Bonella, Dirk Theegarten, Balazs Dome, Christine Pirker, Walter Berger, Luca Hegedüs, Marcell Baranyi, Martin Schuler, Sophie Deshayes, Servet Bölükbas, Clemens Aigner, Christophe Blanquart, Balazs Hegedüs Abstract Objectives: Pleural mesothelioma (PM) is a rare disease with dismal outcome. Systemic treatment options include chemotherapy…
Read MoreDetermining the clinical utility of a breath test for screening an asbestos-exposed population for pleural mesothelioma: baseline results
Journal of Breath Research 2023 September 21 [Link] Kathleen Zwijsen, Eline Schillebeeckx, Eline Janssens, Joris Van Cleemput, Tom Richart, Veerle F Surmont, Kristiaan Nackaerts, Elly Marcq, Jan P van Meerbeeck, Kevin Lamote Abstract Pleural mesothelioma (PM) is an aggressive cancer of the serosal lining of the thoracic cavity, predominantly caused by asbestos exposure. Due to…
Read MoreEpithelioid Mesothelioma Patients with Very Long Survival Display Defects in DNA Repair
Cancers 2023 August 29 [Link] Monica Ganzinelli, Federica Guffanti, Anna Ianza, Navid Sobhani, Sergio Crovella, Fabrizio Zanconati, Cristina Bottin, Marco Confalonieri, Stefano Fumagalli, Alessandra Guglielmi, Daniele Generali, Giovanna Damia Abstract Aim: DNA repair has an important role in malignant pleural mesothelioma (MPM) tumorigenesis and progression. Prognostic/predictive biomarkers for better management of MPM patients are needed.…
Read MoreExtrathoracic Metastases in Pleural Mesothelioma
JTO Clinical and Research Reports 2023 August 2 [Link] Ibiayi Dagogo-Jack, Beow Y Yeap, Mari Mino-Kenudson, Subba R Digumarthy Abstract Introduction: Guidelines recommend obtaining a computed tomography scan of the chest for the staging of pleural mesothelioma and for assessing response to treatment. Consensus is lacking regarding the necessity of serial imaging of distant extrathoracic…
Read MorePrognosis prediction of patients with malignant pleural mesothelioma using conditional variational autoencoder on 3D PET images and clinical data
Medical Physics 2023 August 31 [Link] Hidetoshi Matsuo, Kazuhiro Kitajima, Atsushi K Kono, Kozo Kuribayashi, Takashi Kijima, Masaki Hashimoto, Seiki Hasegawa, Koichiro Yamakado, Takamichi Murakami Abstract Background: Deep learning (DL) has been widely used for diagnosis and prognosis prediction of numerous frequently occurring diseases. Generally, DL models require large datasets to perform accurate and reliable…
Read MoreCancer-Associated Fibroblasts Influence Survival in Pleural Mesothelioma: Digital Gene Expression Analysis and Supervised Machine Learning Model
International Journal of Molecular Science 2023 August 4 [Link] Sabrina Borchert, Alexander Mathilakathu, Alina Nath, Michael Wessolly, Elena Mairinger, Daniel Kreidt, Julia Steinborn, Robert F H Walter, Daniel C Christoph, Jens Kollmeier, Jeremias Wohlschlaeger, Thomas Mairinger, Luka Brcic, Fabian D Mairinger Abstract The exact mechanism of desmoplastic stromal reaction (DSR) formation is still unclear. The…
Read MoreLongitudinal monitoring of response to chemotherapy in patients with malignant pleural mesothelioma by biomarkers
Cancer Biomarkers 2023 [Link] Filiz Bogar, Guntulu Ak, Selma Metintas, Adnan Ayhanci, Muzaffer Metintas Abstract Background: The aim of the study was to longitudinally investigate the serum levels of mesothelin, sestrin1, hyaluronan synthase 2 (HAS2), midkine, and high mobility group box 1 (HMGB1) before and after chemotherapy and at the time of relapse in malignant…
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