Causation
Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update
International Journal of Molecular Sciences 2022 December 6 [Link] Phillip Munson, Arti Shukla Abstract Malignant mesothelioma (MM) is a devastating cancer of mesothelial cells, caused by asbestos exposure. Limited knowledge regarding the detection of asbestos exposure and the early diagnosis of MM, as well as a lack of successful treatment options for this deadly cancer,…
Read MoreIdentification of a new potential plasmatic biomarker panel for the diagnosis of malignant pleural mesothelioma
La Medicina del Lavoro 2022 December 7 [Link] Luca Ferrari, Simona Iodice, Laura Cantone, Barbara Dallari, Laura Dioni, Lorenzo Bordini, Alessandro Palleschi, Carolina Mensi, Angela Cecilia Pesatori Abstract Background: Malignant pleural mesothelioma (MPM) is a rare highly aggressive tumor strongly associated with asbestos exposure and characterized by poor prognosis. Currently, diagnosis is based on invasive…
Read MoreInflammation as a chemoprevention target in asbestos-induced malignant mesothelioma
Carcinogenesis 2022 November 10 [Link] Yuwaraj Kadariya, Eleonora Sementino, Ujjawal Shrestha, Greg Gorman, Jonathan M White, Eric A Ross, Margie L Clapper, Nouri Neamati, Mark Steven Miller, Joseph R Testa Abstract Malignant mesothelioma (MM) is an incurable cancer of the serosal lining that is often caused by exposure to asbestos. Therefore, novel agents for the…
Read MoreRate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers
Thorax 2022 November 10 [Link] Danila Azzolina, Dario Consonni, Daniela Ferrante, Dario Mirabelli, Stefano Silvestri, Ferdinando Luberto, Alessia Angelini, Francesco Cuccaro, Anna Maria Nannavecchia, Enrico Oddone, Massimo Vicentini, Francesco Barone-Adesi, Tiziana Cena, Lucia Mangone, Francesca Roncaglia, Orietta Sala, Simona Menegozzo, Roberta Pirastu, Sara Tunesi, Elisabetta Chellini, Lucia Miligi, Patrizia Perticaroli, Aldo Pettinari, Vittoria Bressan, Enzo…
Read MoreDisturbance of the Warburg effect by dichloroacetate and niclosamide suppresses the growth of different sub-types of malignant pleural mesothelioma in vitro and in vivo
Frontiers in Pharmacology 2022 October 11 [Link] Sze-Kwan Lam, Sheng Yan, Joyce Sze-Man Lam, Yuqian Feng, Mahjabin Khan, Caoyang Chen, Frankie Chi-Fat Ko, James Chung-Man Ho Abstract Background: Inhalation of asbestos fibers is the most common cause of malignant pleural mesothelioma (MPM). In 2004, the United States Food and Drug Administration approved a combination of…
Read MoreBlood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort
International Journal of Cancer 2022 October 28 [Link] Alessandra Allione, Clara Viberti, Ilaria Cotellessa, Chiara Catalano, Elisabetta Casalone, Giovanni Cugliari, Alessia Russo, Simonetta Guarrera, Dario Mirabelli, Carlotta Sacerdote, Marco Gentile, Fabian Eichelmann, Matthias B Schulze, Sophia Harlid, Anne Kirstine Eriksen, Anne Tjønneland, Martin Andersson, Martijn E T Dollé, Heleen Van Puyvelde, Elisabete Weiderpass, Miguel Rodriguez-Barranco,…
Read MoreHeterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment
Molecular Oncology 2022 October 11 [Link] Ananya Hariharan, Weihong Qi, Hubert Rehrauer, Licun Wu, Manuel Ronner, Martin Wipplinger, Jelena Kresoja-Rakic, Suna Sun, Lucia Oton-Gonzalez, Marika Sculco, Véronique Serre-Beinier, Clément Meiller, Christophe Blanquart, Jean-François Fonteneau, Bart Vrugt, Jan Hendrik Rüschoff, Isabelle Opitz 8, Didier Jean, Marc de Perrot, Emanuela Felley-Bosco Abstract We previously observed increased levels…
Read MoreAssessment of miR-103a-3p in leukocytes-No diagnostic benefit in combination with the blood-based biomarkers mesothelin and calretinin for malignant pleural mesothelioma diagnosis
PLoS One 2022 October 14 [Link] Carmina Jiménez-Ramírez, Daniel Gilbert Weber, Guadalupe Aguilar-Madrid, Alexander Brik, Cuauhtémoc Arturo Juárez-Pérez, Swaantje Casjens, Irina Raiko, Thomas Brüning, Georg Johnen, Alejandro Cabello-López Abstract Malignant pleural mesothelioma (MPM) is a cancer associated with asbestos exposure and its diagnosis is challenging due to the moderate sensitivities of the available methods. In…
Read MoreJourney to the centre of the lung. The perspective of a mineralogist on the carcinogenic effects of mineral fibres in the lungs
Journal of Hazardous Materials 2023 January 15 [Link] Alessandro F Gualtieri Abstract This work reviews the bio-chemical mechanisms leading to adverse effects produced when mineral fibres are inhaled and transported in the lungs from the perspective of a mineralogist. The behaviour of three known carcinogenic mineral fibres (crocidolite, chrysotile, and fibrous-asbestiform erionite) during their journey…
Read MoreBMP and activin membrane-bound inhibitor regulate connective tissue growth factor controlling mesothelioma cell proliferation
BMC Cancer 2022 September 15 [Link] Nguyen Truong Duc Hoang, Ghmkin Hassan, Tomoya Suehiro, Yuichi Mine, Tohru Matsuki, Makiko Fujii Abstract Background: Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our…
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