Causation
Genetic analysis of familial predisposition in the pathogenesis of malignant pleural mesothelioma
Journal of Cancer Research and Clinical Oncology 2023 April 7 [Link] Muhittin Akarsu, Güntülü Ak, Emine Dündar, Muzaffer Metintaş Abstract Purpose: Mesothelioma is the primary tumor of the mesothelial cell membrane. The most important etiology is asbestos exposure. The development of malignant mesothelioma in very few of the population exposed to asbestos and its frequent…
Read MoreAssociation of mesothelioma deaths with neighborhood asbestos exposure due to a large-scale asbestos-cement plant
Cancer Science 2023 April 3 [Link] Yuri Kitamura, Ling Zha, Rong Liu, Masayuki Shima, Tomoki Nakaya, Norio Kurumatani, Shinji Kumagai, Junko Goji, Tomotaka Sobue Abstract A causal relationship between mesothelioma and occupational asbestos exposure is well known, while some studies have shown a relationship to non-occupational exposures. The aim of this study was to quantify…
Read MoreUltrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
Environmental Health 2022 December 21 [Link] Kenneth T Bogen Abstract Alterations in complex cellular phenotype each typically involve multistep activation of an ultrasensitive molecular switch (e.g., to adaptively initiate an apoptosis, inflammasome, Nrf2-ARE anti-oxidant, or heat-shock activation pathway) that triggers expression of a suite of target genes while efficiently limiting false-positive switching from a baseline…
Read MoreDeveloping sustainable patient and public involvement in mesothelioma research: multi-method exploration with researchers, patients, carers, and patient organisations
Research Involvement and Engagement 2023 March 25 [Link] Afrodita Marcu, Fiona McGregor, Bernadette Egan, Kate Hill, Tim Cook, Anne Arber Abstract Background: Rare diseases where prognosis is poor provide limited scope for patient and public involvement (PPI). One such disease is mesothelioma, a cancer of the lung pleura or of the peritoneum caused by exposure…
Read MoreNew pathogenic germline variants identified in mesothelioma
Lung Cancer 2023 March 15 [Link] Laila Belcaid, Birgitte Bertelsen, Karin Wadt, Ida Tuxen, Iben Spanggaard, Martin Højgaard, Jens Benn Sørensen, Jesper Ravn, Ulrik Lassen, Finn Cilius Nielsen, Kristoffer Rohrberg, Christina Westmose Yde Abstract Background: Mesothelioma (MM) is associated with asbestos exposure, tumor heterogeneity and aggressive clinical behavior. Identification of germline pathogenic variants (PVs) in…
Read MoreBenefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma
Cancers 2023 February 28 [Link] Mhd Ouis Al Khatib, Giulia Pinton, Laura Moro, Chiara Porta Abstract Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer that is mainly associated with prior exposure to asbestos fibers. Despite being a rare cancer, its global rate is increasing and the prognosis remains extremely poor. Over the last two…
Read MoreThe Evolving Role of Immune-Checkpoint Inhibitors in Malignant Pleural Mesothelioma
Journal of Clinical Medicine 2023 February 22 [Link] Maxime Borgeaud, Floryane Kim, Alex Friedlaender, Filippo Lococo, Alfredo Addeo, Fabrizio Minervini Abstract Malignant pleural mesothelioma (MPM) is a rare cancer usually caused by asbestos exposure and associated with a very poor prognosis. After more than a decade without new therapeutic options, immune checkpoint inhibitors (ICIs) demonstrated…
Read MoreSmall RNA-Seq Transcriptome Profiling of Mesothelial and Mesothelioma Cell Lines Revealed microRNA Dysregulation after Exposure to Asbestos-like Fibers
Biomedicines 2023 February 13 [Link] Veronica Filetti, Claudia Lombardo, Carla Loreto, George Dounias, Massimo Bracci, Serena Matera, Lucia Rapisarda, Venerando Rapisarda, Caterina Ledda, Ermanno Vitale Abstract Environmental exposure to fibers of respirable size has been identified as a risk for public health. Experimental evidence has revealed that a variety of fibers, including fluoro-edenite, can develop…
Read MoreMEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma
Cell Death Discovery 2023 February 10 [Link] Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R R Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F Ochsenbein, Thomas M Marti, Gregor J Kocher, Ralph A Schmid, Patrick Dorn, Ren-Wang Peng Abstract Malignant pleural mesothelioma (MPM) is a lethal…
Read MoremiR-142-3p Suppresses Invasion and Adhesion of Mesothelioma Cells by Downregulating ITGAV
Pathobiology 2023 Febrary 1 [Link] Ihiro Endo, Vishwa Jeet Amatya, Kei Kushitani Tetsuya Nakagiri, Kohei Aoe, Yukio Takeshima Abstract Introduction: Malignant mesothelioma is an aggressive cancer associated with asbestos exposure. Currently, the efficacy of therapeutics is limited in malignant mesothelioma, and developing more effective therapies is the need of the hour. Non-coding RNAs (ncRNAs), including…
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