The Accuracy of Video-Assisted Thoracic Surgery Pleural Biopsy in Patients with Suspected Diffuse Pleural Mesothelioma: A Real-Life Study

Journal of Clinical Medicine 2025 December 20 [Link] Ludovica Balsamo, Enrica Migliore, Eleonora Della Beffa, Luisa Delsedime, Paolo Olivo Lausi, Daniela Di Cuonzo, Filippo Lococo, Paraskevas Lyberis, Dario Mirabelli, Mauro Giulio Papotti, Enrico Ruffini, Francesco Guerrera Abstract Background: The heritage of occupational and environmental asbestos exposure in Piedmont, Italy, has resulted in an enduring diffuse…

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Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification

International Journal of Cancer 2025 December 30 [Link] Khadija Sana Hafeez, Carla Debernardi, Alessandra Allione, Elton Jalis Herman, Simonetta Guarrera, Daniela Ferrante, Anna Aspesi, Marika Sculco, Marta La Vecchia, Carlotta Sacerdote, Federica Grosso, Christina M Lill, Giovanna Masala, Marcela Guevara, Matthias B Schulze, Salvatore Panico, Yaszan Asgari, Seehyun Park, Giovanna Tagliabue, Anne Tjønneland, Antonio Agudo,…

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Epithelioid Mesothelioma Cells Exhibit Increased Ferroptosis Sensitivity Compared to Non-Epithelioid Mesothelioma Cells

Cancers 2025 December 13 [Link] Tatsuhiro Sato, Ikue Hasegawa, Haruna Ikeda, Taichi Ohshiro, Lisa Kondo-Ida, Satomi Mukai, Satoshi Ohte, Tohru Maeda, Yoshitaka Sekido Abstract Background/Objectives: Mesothelioma is a highly aggressive tumor with a poor prognosis that typically develops after a long latency period following asbestos exposure. Although immunotherapy combined with chemotherapy is increasingly used, the…

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Co-occurrence of peritoneal mesothelioma and genitourinary cancers: a case series with comparative outcomes

Pleura and Peritoneum 2025 November 3 [Link] Emma M Bradley, James L Rogers, Marissa C Kuo, Deepa Magge Abstract Objectives: Peritoneal mesothelioma (PM) shares features with genitourinary (GU) malignancies, including histologic appearance, embryologic origin and genetic predispositions. However, data on their co-occurrence are limited. The study presents a case series of PM patients with associated…

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Circulating microRNAs as biomarkers for risk assessment and prognostic stratification of pleural mesothelioma

Lung Cancer 2025 December [Link] Evgeniya Sharova, Paola Del Bianco, Loredana Urso, Micol Silic-Benussi, Daniela Scattolin, Donna M D’Agostino, Giulia Pasello, Vincenzo Ciminale Abstract Introduction: Pleural mesothelioma (PM) is an aggressive neoplasm associated with asbestos exposure. Clinical management of PM poses major challenges due to the lack of reliable markers for early diagnosis and prognostic…

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Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature

World Journal of Clinical Cases 2025 November 16 [Link] Aikedan Aisikaer, Mo-Mo Sun, Jie Shen Abstract Background: Malignant pleural mesothelioma (MPM), a rare aggressive malignancy, is primarily caused by asbestos exposure. MPM typically affects older adults (median age, 76 years), is uncommon in those under age 50 years and shows male predominance. Based on the…

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A Rare Clinical Presentation of Malignant Pleural Mesothelioma With Central Nervous System Metastases: A Case Report

Cureus 2025 September 14 [Link] Magdalena A Miernik-Skrzypczak, Elwira Misztela-Lisiecka, Piotr Nowakowski, Anna Strozak, Grazyna Waska Abstract Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer arising from the pleural mesothelial cells, most often associated with long-term asbestos exposure. Symptoms are typically nonspecific, including shortness of breath, chest pain, and pleural effusion, which may…

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Apical Malignant Pleural Mesothelioma Presenting as Horner’s Syndrome: A Case Report

Cureus 2025 October 13 [Link] Shruthi Mankal, Chris Jacobs Abstract Horner’s syndrome is a well-recognized presentation of apical lung tumors, though rarely associated with malignant pleural mesothelioma (MPM), with only a few cases documented. We report the case of an 82-year-old man with persistent right-sided chest pain who developed unilateral right-sided ptosis, miosis and a…

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The role of non-coding RNAs in pleural mesothelioma

Translational Oncology 2025 September 29 [Link] Giulia Tonnini, Giulia Di Mauro, Maria Letizia Tramarin, Anna Meneghetti, Ilaria Bononi, Chiara Mazziotta, John Charles Rotondo, Elisa Mazzoni, Maria Rosa Iaquinta, Elisabetta Trabetti, Cristina Bombieri, Monica De Mattei, Mauro Tognon, Fernanda Martini Abstract Background: Pleural mesothelioma (PM) is a rare and highly aggressive tumor, primarily caused by asbestos…

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