Type of Assessment:
Cellular Plasticity in Malignant Transformation: Mesothelial Cells
Pathobiology 2026 April 29 [Link] Claire W Michael, Ben Davidson Abstract Background: Mesothelial proliferations range from reactive lesions to benign and malignant tumors, bearing witness to the plasticity of these cells. Their diagnosis often requires combination of morphological assessment, immunohistochemistry, and molecular testing. Summary: Considerable progress has been made in recent years in all the…
Read MoreParaneoplastic Brachial Amyotrophic Diplegia and Encephalitis With Ma2-IgG During Immune Checkpoint Inhibitor Use for Mesothelioma: A Case Report
JTO Clinical and Research Reports 2026 March 6 [Link] Sanem Pinar Uysal, Shervin Badihian, Karlo Toljan, Nirmal Andrapalliyal, James Stevenson, Jonathan Lee, Amy Kunchok Abstract Background: Immune checkpoint inhibitors (ICIs) improve cancer survival but can cause neurologic immune-related adverse events. Ma2-IgG-associated paraneoplastic neurologic syndrome typically presents with central nervous system involvement in patients with testicular…
Read MoreImmunotherapy resistance and strategies in malignant pleural mesothelioma
Cancer Drug Resistance 2026 March 26 [Link] Wanyi Xia, Yulong Zhang, Juanzhi Zhao, Xiaoli Tan, Shaolong Ju, Wei Zou, Chaoqun Chen, Chunwei Li, Yanghua Xu, Yingming Peng, Shengqiao Li Abstract Malignant pleural mesothelioma (MPM) remains one of the most aggressive thoracic malignancies, characterized by profound resistance to conventional modalities such as surgery, chemotherapy, and radiotherapy,…
Read MoreMultiplexed single-cell and spatial profiling reveal B cells and tertiary lymphoid structures as prognostic indicators in pleural mesothelioma
British Journal of Cancer 2026 July [Link] Angelica Rigutto, Nicolás G Núñez, Jenny C Kienzler, Isabelle Opitz, Mayura Meerang, Martina Haberecker, Nadine Fournier, Joao Lourenço, Raphael Gottardo, Karina Silina, Anurag Gupta, Burkhard Becher, Alessandra Curioni-Fontecedro Abstract Background: Pleural mesothelioma (PM) is an orphan disease with poor prognosis. While T cell dynamics in the tumor microenvironment…
Read MoreTumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study
Nature Genetics 2026 May [Link] Luana Calabrò, Francesca P Caruso, Alessia Covre, Teresa M R Noviello, Maria F Lofiego, Rossella Tufano, Luigi Ferraro, Piera Grisolia, Antonio De Falco, Vincenzo Lagano, Francesco Sgambelluri, Giovanna Sabella, Giulia Rossi, Giulia Gibilisco, Francesco Marzani, Emma Bello, Elena Simonetti, Vincenzo D’Alonzo, Michele Caraglia, Sandra Coral, Antonina De Angelis, Luigi Cerbone,…
Read MoreTumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study
Nature Genetics 2026 May [Link] Luana Calabrò, Francesca P Caruso, Alessia Covre, Teresa M R Noviello, Maria F Lofiego, Rossella Tufano, Luigi Ferraro, Piera Grisolia, Antonio De Falco, Vincenzo Lagano, Francesco Sgambelluri, Giovanna Sabella, Giulia Rossi, Giulia Gibilisco, Francesco Marzani, Emma Bello, Elena Simonetti, Vincenzo D’Alonzo, Michele Caraglia, Sandra Coral, Antonina De Angelis, Luigi Cerbone,…
Read MoreEmerging Strategies in the Diagnosis and Treatment of Pleural Mesothelioma: An Overview
Thoracic Cancer 2026 April [Link] Raffaella Pagliaro, Beatrice Leonardi, Angela Schiattarella, Grazia Bergameo, Carmine Picone, Adolfo Gallipoli D’Errico, Filippo Scialò, Fabio Perrotta, Maria Luisa De Rimini, Alfonso Fiorelli, Andrea Bianco Abstract Pleural mesothelioma (PM) is a rare and aggressive cancer arising from pleural mesothelial cells with a strong association to asbestos exposure. Among the diagnostic…
Read MoreThe Society of Thoracic Surgeons 2026 Expert Consensus on the Multimodal Treatment of Pleural Mesothelioma
The Annals of Thoracic Surgery 2026 July [Link] Jeffrey B Velotta, Anja C Roden, Jonathan Rice, Charles B Simone, Bansari Upadhyay, Pallavi Sood, Daniel L Miller, R Taylor Ripley, Andrea Wolf, Bryan M Burt, Samuel S Kim, Isabelle Opitz, Hedy L Kindler, Harvey I Pass, J W Awori Hayanga, Valerie Rusch, Raphael Bueno Abstract Background:…
Read MoreCheckpoint kinase 1 protein as a diagnostic marker for pleural mesothelioma
Journal of the American society of Cytopathology 2026 March 28 [Link] Azadeh Asghari Birbaneh, Christos Meristoudis, Caspar Bundgaard Nielsen, Weronika Maria Szejniuk, Morten Johansen, Peter Derek Christian Leutscher, Vasiliki Panou, Oluf Dimitri Røe Abstract Introduction: Pleural mesothelioma (PM) is an aggressive malignancy that poses diagnostic challenges, particularly in cytological specimens. Checkpoint kinase 1 (CHK1); a…
Read MoreRegional immunosuppression and associated systemic markers in focally relapsed sarcomatoid mesothelioma: case report
Journal for Immunotherapy of Cancer 2026 April 15 [Link] Hely Ollila, Prateek Kulkarni, Hyojin Kim, Pratiti Ankola, Navin K Chintala, Carlos Thomas, Jennifer L Sauter, Michael Offin, Prasad S Adusumilli Abstract A 52-year-old man presented with sarcomatoid diffuse pleural mesothelioma that had relapsed at an isolated site after a complete response to dual-immune checkpoint inhibition…
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