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Low baseline cGAS expression is associated with longer progression-free survival in patients with pleural mesothelioma
Lung Cancer 2026 September [Link] Antoine Torchiat, Karina Silina, Arya Ashok Nair, Laura Viktoria Heeb, Isabelle Opitz, Anurag Gupta, Alessandra Curioni-Fontecedro Abstract Introduction: The cyclic GMP-AMP synthase (cGAS)/STING pathway, a central DNA-sensing mechanism, is known to activate anti-tumor immune response but may also promote tumor progression when chronically activated. Given the role of asbestos-induced chronic…
Read MoreSuccessful Diagnostic Confirmation of Malignant Pleural Mesothelioma With Extensive Pleural Adhesions Using Pleural Cryobiopsy Under Local Anaesthesia
Respirology Case Reports 2026 July 29 [Link] Shotaro Otaki, Mikito Suzuki, Kaito Yano, Tomohiro Imoto, Reiko Shimizu, Tsunekazu Hishima, Kazuo Nakagawa Abstract Local anaesthesia thoracoscopy using flex-rigid thoracoscope is useful for diagnosing pleural lesions, but it is generally not indicated in cases with extensive pleural adhesions. We report a case of malignant pleural mesothelioma (MPM)…
Read MoreSimultaneous Occurrence of Well-Differentiated Papillary Mesothelial Tumor and Multicystic Mesothelioma
Diagnostics 2026 July 15 [Link] Dražen Miličić, Snježana Tomić, Boris Delić, Marko-Dražen Mimica Abstract We report a rare case of simultaneous well-differentiated papillary mesothelial tumor (WDPMT) and multicystic mesothelioma. The concurrent occurrence of these entities is exceptionally uncommon and may pose challenges during surgical intervention. Both lesions are rare mesothelial proliferations that are often identified…
Read MoreGlycan Fingerprint of Malignant Pleural Mesothelioma
International Journal of Molecular Sciences 2026 July 9 [Link] Lovro Kavur, Thomas S Klarić, Nikol Mraz, Nina Šimunić-Briški, Dora Lalić, Gordan Lauc, Martin Martinić, Lovorka Batelja Vuletić, Marina Martinić Kavur, Sven Seiwerth, Ozren Gamulin Abstract Malignant pleural mesothelioma (MPM) is an aggressive pleural tumor associated with asbestos exposure. Poor clinical outcome of MPM is often…
Read MoreEfficacy of Perioperative Platinum-Pemetrexed Chemotherapy Combined With Pleurectomy/Decortication for Pleural Mesothelioma
The Annals of Thoracic Surgery 2026 July 25 [Link] Akifumi Nakamura, Masaki Hashimoto, Nobuyuki Kondo, Seiji Matsumoto, Ayumi Kuroda, Kyoshiro Takegahara, Takashi Kijima, Seiki Hasegawa, Soichiro Funaki Abstract Background: The optimal timing of chemotherapy in multimodal treatment of pleural mesothelioma remains unclear. This study evaluated the efficacy of adjuvant chemotherapy (AC) after neoadjuvant chemotherapy (NAC)…
Read MoreThe Prognostic Significance of BRCA1-Associated Protein 1(BAP1) in Malignant Pleural Mesothelioma: A Systematic Review and Meta-Analysis
Clinical Medicine Insights Oncology 2026 July 24 [Link] Jiaojiao Hong, Xianzi Dai, Jiangxia Yuan, Chengyu Chen, Zhengxing Huo, Chunwei Xu, Qian Wang Abstract Background: Malignant pleural mesothelioma (MPM) originates from pleural mesothelial cells and represents a highly aggressive malignancy. Characterized by a prolonged latency period, poor survival prognosis, and non-specific clinical manifestations, MPM poses significant…
Read MoreEpiproteomic profiling identifies histone H4 hyperacetylation as a prognostic marker in pleural mesothelioma
Lung Cancer 2026 September [Link] Roberta Noberini, Ioanna Bischinioti, Simone Zanetti, Alessandro Vai, Giulia Sedda, Eltjona Mane, Claudia Bardoni, Giulia Robusti, Marianna D’Ercole, Rosanna Mancari, Ugo Cavallaro, Nicoletta Colombo, Luca Bertolaccini, Mariano Lombardi, Nicola Fusco, Lorenzo Spaggiari, Domenico Galetta, Tiziana Bonaldi Abstract Pleural mesothelioma (PM) is an aggressive tumor that arises from mesothelial cells as…
Read MoreTreatment for Oligo-recurrence of Diffuse Pleural Mesothelioma After Extended Pleurectomy/Decortication
Annals of Surgical Oncology 2026 October [Link] Ryo Wakejima, Hironori Ishibashi, Ayaka Asakawa, Yuya Ishikawa, Yusuke Sugita, Kenichi Okubo Abstract Background: We evaluate recurrence patterns and assess the efficacy of local treatment for oligo-recurrence in patients with diffuse pleural mesothelioma (PM) following extended pleurectomy/decortication (P/D) with multimodal therapy. Methods: This retrospective study included 69 patients…
Read MoreResearch progress on the regulation of mesothelioma driven by deubiquitinating enzyme BAP1
Clinical and Experimental Medicine 2026 July [Link] Wan-Ting Xuan, Yao Dong, Si-Yuan Ma, Man Liu, Xiao-Qi Liu, Na-Na Yao, Lan-Xi Hu, Ling-Ling Shi, Lin Ma, Jing-Hui Bai, Bo Huang Abstract Mesothelioma is a highly aggressive malignancy that develops through the combined influence of several factors, including environmental exposure, genetic susceptibility, immune status, and aberrant activation…
Read MoreMaintenance pemetrexed after platinum pemetrexed chemotherapy and survival outcomes in malignant pleural mesothelioma in a multicenter real world study
Scientific Reports 2026 July 15 [Link] Okan Aydin, Zehra Sucuoglu Isleyen, Mert Erciyestepe, Ahmet Emin Ozturk, Sermin Dinc Sonusen, Tugay Atasever, Simay Cokgezer, Ebru Cicek, Ayse Gul Satman Durmaz, Lamia Seker Can, Gozde Balkaya Aykut, Tuba Baydas, Miray Aydogan, Seval Ay Ersoy, Muhammed Mustafa Atci, Kayhan Erturk Abstract Malignant pleural mesothelioma (MPM) is an aggressive…
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