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Cytopathologic Features of Metastatic Malignant Mesothelioma With SMARCB1 (INI-1) Deficient Diagnosed by Ultrasound-Guided Fine-Needle Aspiration: A Case Report
Diagnostic Cytopathology 2025 December 29 [Link] Jun Yang, Juandi Liu, Jing Jin, Deng Pan, Lei Shao Abstract Malignant mesothelioma (MM) is a rare yet aggressive neoplasm that arises from mesothelial cells lining the thoracic and abdominal cavities, the pericardium, and the tunica testis. Characterized by rapid progression, high invasiveness, and a poor prognosis, MM poses…
Read MoreNear-infrared spectroscopy combined with machine learning for plasma-based discriminant diagnosis of malignant mesothelioma: a retrospective study
PeerJ 2025 December 19 [Link] Yixuan Gu, Ruting Wang, Weimin Mao, Zhongjian Chen Abstract This study developed a novel, non-invasive platform integrating near-infrared spectroscopy (NIRS) with machine learning (ML) to address the critical clinical challenge of misdiagnosing malignant mesothelioma (MM). We analyzed plasma samples from 99 individuals (29 MM, 41 lung cancer (LC), and 29…
Read MoreThe Role of Radiotherapy After Pleurectomy/Decortication for Malignant Pleural Mesothelioma: State of the Art
Journal of Personalized Medicine 2025 December 1 [Link] Marco Andolfi, Michele Salati, Majed Refai Abstract Background: Considering the increased need to deliver adjuvant radiotherapy (RT) after pleurectomy/decortication (P/D) for malignant pleural mesothelioma (MPM) without exceeding the tolerance of the adjacent normal tissue, new advanced RT technologies have been developed. However, radiation to the whole hemithorax…
Read MoreBaicalein Inhibits Proliferation, Migration, and Invasion of Mesothelioma Cells Through the p53-FOXM1 Signaling Axis
Cancer Management and Research 2025 December 19 [Link] Xin-Yi Zheng, Chao Guo, Jie Peng, Ping-Xiang Tang, Ze Xia, Wen-Fei Xu, Xu-Hui Li Abstract Purpose: Baicalein, a natural flavonoid derived from the root of Scutellaria baicalensis, has demonstrated antitumor efficacy in several cancers. However, its effects on human mesothelioma remain largely unclear. This study evaluates the…
Read MoreNear-infrared spectroscopy combined with machine learning for plasma-based discriminant diagnosis of malignant mesothelioma: a retrospective study
PeerJ 2025 December 19 [Link] Yixuan Gu, Ruting Wang, Weimin Mao, Zhongjian Chen Abstract This study developed a novel, non-invasive platform integrating near-infrared spectroscopy (NIRS) with machine learning (ML) to address the critical clinical challenge of misdiagnosing malignant mesothelioma (MM). We analyzed plasma samples from 99 individuals (29 MM, 41 lung cancer (LC), and 29…
Read MoreMerlin Immunohistochemistry Is Useful in the Differential Diagnosis of Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia
Pathology International 2026 January [Link] Kohei Aoe, Kei Kushitani, Vishwa Jeet Amatya, Tetsuya Nakagiri, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima Abstract The differential diagnosis of epithelioid mesothelioma and reactive mesothelial hyperplasia can be challenging based on morphology alone, particularly in small specimens. Consequently, the use of ancillary techniques, such as immunohistochemistry for BRCA1-associated protein 1,…
Read MoreThe INDEPSO-ISPSM Consensus on Peritoneal Malignancies-Diagnosis and Management of Peritoneal Mesothelioma
Indian Journal of Surgical Oncology 2025 December [Link] Ambarish Chatterjee, Ashwin K Rajagopal, Vivekanand Sharma, Niharika Garach, Ninad Katdare, Rohit Kumar, Swapnil Patel, Mukurdipi Ray, Somashekhar Sp, Sanket Mehta, Vivek Sukumar, Aditi Bhatt Abstract We report the results of a consensus exercise covering the basics of management of peritoneal mesothelioma (PeM) (diagnostic evaluation, patient selection…
Read MoreCo-occurrence of peritoneal mesothelioma and genitourinary cancers: a case series with comparative outcomes
Pleura and Peritoneum 2025 November 3 [Link] Emma M Bradley, James L Rogers, Marissa C Kuo, Deepa Magge Abstract Objectives: Peritoneal mesothelioma (PM) shares features with genitourinary (GU) malignancies, including histologic appearance, embryologic origin and genetic predispositions. However, data on their co-occurrence are limited. The study presents a case series of PM patients with associated…
Read MoreDiagnostic potential of a novel immunohistochemical marker, GFPT2, in differentiating mesothelioma from its morphological mimics
Histopathology 2025 December 15 [Link] Jia Wei, Xiaofang Ma, Gang Chen, Yan Wang, Qinhe Fan, Qixing Gong Abstract Aims: Mesothelioma (MESO) is a rare and aggressive tumour originating from mesothelial cells, primarily affecting the pleura and peritoneum. Its diagnosis remains challenging due to non-specific clinical, radiological and histopathological features, compounded by morphological diversity and overlapping…
Read MoreGlobal patterns and trends in mesothelioma incidence: A retrospective cross-sectional study
Lung Cancer 2026 January [Link] Leiwen Fu, Ke Liu, Yang Liu, Yanxiao Gao, Bingyi Wang, Yuxian Sun, Wei Shu, Yujia Ning, Minyi Zhang, Jian Du, Liang Li Abstract Background: Mesothelioma is a rare and aggressive malignancy primarily caused by asbestos exposure; it predominantly affects older adults with a history of occupational contact. Methods: This population-based…
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