Photochemistry and Photobiology 2022 August 23 [Link]

Hongjing Sun, Michele M Kim, Yi Hong Ong, Andreea Dimoft, Sunil Singhal, Theresa M Busch, Keith A Cengel, Timothy C Zhu


Photodynamic therapy (PDT) has been used to treat malignant pleural mesothelioma. Current practice involves delivering light to a prescribed light fluence with a point source, monitored by eight isotropic detectors inside the pleural cavity. An infrared (IR) navigation system was used to track the location of the point source throughout the treatment. The recorded data was used to reconstruct the pleural cavity and calculate the light fluence to the whole cavity. An automatic algorithm was developed recently to calculate the detector positions based on recorded data within an hour. This algorithm was applied to patient case studies and the calculated results were compared to the measured positions, with an average difference of 2.5 cm. Calculated light fluence at calculated positions were compared to measured values. The differences between the calculated and measured light fluences were within 14% for all cases, with a fixed scattering constant and a dual correction method. Fluence surface histogram (FSH) was calculated for photofrin-mediated PDT to be able to cover 80% of pleural surface area to 50 J/cm2 (83.3% of 60 J/cm2 ). The study demonstrates that it will be possible to eliminate the manual measurement of the detector positions, reducing the patient’s time under anesthesia.