Type of Mesothelioma:
Emerging New Targets in Systemic Therapy for Malignant Pleural Mesothelioma
Cancers 2024 March 22 [Link] Karen M Yun, Lyudmila Bazhenova Abstract Malignant pleural mesothelioma (MPM) is a heterogeneous cancer composed of distinct molecular and pathologic subtypes. Unfortunately, MPM is aggressive, and current therapies for advanced, unresectable disease remain limited to cytotoxic chemotherapy and immunotherapy. Our understanding of the genomic landscape of MPM is steadily growing,…
Read MoreHigh mobility group box 1 mediates inflammatory responses in malignant peritoneal mesothelioma
International Immunopharmacology 2024 April 12 [Link] Lianfen Wang, Xuesong Wang, Ningning Sun, Weili Liu Abstract Background: Serum high mobility group box 1 (HMGB1) serves as a diagnostic biomarker for malignant peritoneal mesothelioma (MPM) patients, yet its diagnostic significance within MPM tumor tissues remains uncertain. This study aims to elucidate the roles of HMGB1 in MPM.…
Read MoreYAP/TAZ-TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma
Journal of Cellular and Molecular Medicine 2024 April [Link] Kostas A Papavassiliou, Amalia A Sofianidi, Athanasios G Papavassiliou Abstract The Hippo signalling pathway, a highly conserved signalling cassette, regulates organ size by controlling cell growth, apoptosis and stem cell self-renewal. The tumourigenic potential of this pathway is largely attributed to the activity of YAP/TAZ, which…
Read MoreDiagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis
Pathology, Research, and Practice 2024 March 30 [Link] Rafael Parra-Medina, Juan Pablo Castañeda-González, Viviana Chaves-Cabezas, Juan Pablo Alzate, Juan José Chaves Abstract Background: Malignant pleural mesothelioma (MPM) poses diagnostic challenges due to its resemblance to benign pleural pathologies and different histological subtypes. Several immunohistochemistry markers have been employed to aid in accurate diagnosis. Methods: The…
Read MoreThe role of cytoreductive surgery and HIPEC for the treatment of primary and secondary peritoneal malignancies-experience from a tertiary care center in Germany
Langenbeck’s Archives of Surgery 2024 April 8 [Link] Mikko Reese, Ann-Kathrin Eichelmann, Tobias M Nowacki , Andreas Pascher, Judith C Sporn Abstract Purpose: Peritoneal surface malignancies (PSM) are commonly known to have a dismal prognosis. Over the past decades, novel techniques such as cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC), and pressurized intraperitoneal aerosol chemotherapy…
Read MorePatients with mesothelioma and their carer’s experience of diet and appetite: A qualitative insight from the Help-Meso Study
Journal of Human Nutrition and Dietetics 2024 April 7 [Link] Lorelle L Dismore, Leah L Taylor, Avinash Aujayeb, Christopher Hurst, Katherine Swainston Abstract Background: People living with mesothelioma have a high symptom burden that can affect dietary intake and the development of malnutrition, subsequently impacting on patient-related and treatment outcomes. The present study aimed to…
Read MoreGuidelines for Pathologic Diagnosis of Mesothelioma
Archives of Pathology and Laboratory Medicine 2024 April 8 [Link] Aliya N Husain, David B Chapel, Richard Attanoos, Mary Beth Beasley, Luka Brcic, Kelly Butnor, Lucian R Chirieac, Andrew Churg, Sanja Dacic, Francoise Galateau-Salle, Kenzo Hiroshima, Yin P Hung, Sonja Klebe, Thomas Krausz, Andras Khoor, Leslie Litzky, Alberto Marchevsky, Kazuki Nabeshima, Andrew G Nicholson, Elizabeth…
Read MoreEstablishing mesothelioma patient-derived organoid models from malignant pleural effusions
Lung Cancer 2024 March 28 [Link] Ashleigh J Hocking, Lauren A Mortimer, Alexandra L Farrall, Prudence A Russell, Sonja Klebe Abstract Objectives: Pleural mesothelioma is a cancer arising in the cells that line the lungs and chest wall with poor survival and poor response to first-line therapy. Organoid models of cancer can faithfully recapitulate the…
Read MorePleural mesothelioma in situ: a comprehensive review
European Journal of Cancer Prevention 2024 March 11 [Link] Federica Danuzzo, Federico Raveglia, Francesca Spinelli, Chiara Maria Sibilia, Enrico Cassina, Lidia Libretti, Emanuele Pirondini, Antonio Tuoro, Francesca Bono, Maria Emilia Paladino, Diego Cortinovis, Francesco Petrella Abstract Pleural mesothelioma is a rare and aggressive cancer that affects the pleura. In recent years, there has been increasing…
Read MoreImplementation of a high-resolution, high-contrast magnetic resonance imaging protocol with extended delayed phases for peritoneal mesothelioma
Quantitative Imaging in Medicine and Surgery 2024 March 15 [Link] Milica Medved, Hunter D D Witmer, Ankit Dhiman, Yaniv Berger, Scott K Sherman, Enal S Hindi, Samuel G Armato 3rd, Ingrid S Reiser, Aytekin Oto, Roger M Engelmann, Hedy L Kindler, Nisa C Oren, Carla B Harmath, Kiran K Turaga Abstract Background: Imaging of peritoneal…
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