Advances in the molecular biology of malignant mesothelioma

Acta medica Okayama. 2008 Feb;62(1):1-7. [Link] [PDF Full Text] Toyooka S, Kishimoto T, Date H. Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. toyooka@md.okayama-u.ac.jp Abstract Malignant mesothelioma (MM) is a highly aggressive tumor with a dismal prognosis. The incidence of MM is increasing as…

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No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden

Anticancer Research. 2007 Nov-Dec;27(6B):4159-61. [Link] Lundstig A, Dejmek A, Eklund C, Filinic I, Dillner J. Department of Medical Microbiology, Malmö University Hospital, Lund University, 20502 Malmö, Sweden. annika.lundstig@med.lu.se Abstract Simian virus 40 (SV40), a polyoma virus of the rhesus macaque was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells.…

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Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report

Journal of Cutaneous Pathology. 2008 Jan;35(1):70-3. [Epub ahead of print] [Link] Barresi V, Vitarelli E, Barresi G. Dipartimento di Patologia Umana, Policlinico Universitario G. Martino, University of Messina, Italy. Abstract Diffuse malignant peritoneal mesothelioma (DMPM) is a relatively rare neoplasm. Risk factors associated with its development include asbestos exposure, chronic irritation or inflammation of the…

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Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas

Molecular Cancer. 2007 Dec 21;6(1):81 [Epub ahead of print] [Link] Ramos-Nino ME, Blumen SR, Mossman BT. Abstract Silencing of Fra-1, a component of the dimeric transcription factor, activator protein-1 (AP-1), inhibits mRNA expression of c-met and cd44 in rat mesothelioma cells and is causally linked to maintenance of the transformed phenotype. However, the mechanisms of…

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Peritoneal malignant mesothelioma: case report

Il Giornale Di Chirurgia. 2007 Nov-Dec;28(11-12):435-8. [Link] Tenaglia L, Proietti L, Calì S, Trovato S, Accurso N, Di Stefano C, Catania G. Abstract Our study reports peritoneal diffuse malignant mesothelioma (DMM) in a 43 years old male patient, with no exposure to the asbestos in his medical history; the partner of patient was also not…

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SV40 Multiple Tissue Infection and Asbestos Exposure in a Hyperendemic Area for Malignant Mesothelioma

Cancer Research. 67, 8456-8459, September 15, 2007. [Link] Comar M, Rizzardi C, de Zotti R, Melato M, Bovenzi M, Butel JS, Campello C. Department of Public Medicine Sciences, University of Trieste, Trieste, Italy. Abstract To assess the presence of SV40 in malignant mesothelioma tissue, 19 formalin-fixed paraffin-embedded pleural cancer samples of patients from a hyperendemic…

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Simian virus 40 and mesothelioma in Great Britain

Occupational Medicine. 2007 Aug 4; [Epub ahead of print] [Link] Price MJ, Darnton AJ, McElvenny DM, Hodgson JT. Department of Social Medicine, University of Bristol, Bristol, UK. Abstract Background: Simian virus 40 (SV40) is a DNA virus that has been shown capable of infecting and transforming cells in various species. Laboratory studies have suggested that…

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Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma

Pathology International. 2007 Aug;57(8):493-501. [Link] Zekri AR, Bahnassy AA, Mohamed WS, Hassan N, Abdel-Rahman AR, El-Kassem FA, Gaafar R. Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. ncizakri@starnet.com.eg Abstract The association between simian virus (SV40) and malignant pleural mesothelioma (MPM) suggests an etiological role for SV40. However, exact pathogenetic…

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Low prevalence of SV40 in Swiss mesothelioma patients after elimination of false-positive PCR results

Lung Cancer. 2007 Sep;57(3):282-91. Epub 2007 May 21. [Link] Annemarie Zieglera, Christian A. Seemayerb, Marc Hinterbergerc, Peter Vogtc, Colette Bigoscha, Oliver Gautschid, Luigi Tornillob, Daniel C. Betticherd, Holger Mochc, Rolf A. Stahela a Clinic and Policlinic of Oncology, Laboratory of Molecular Oncology, University Hospital, Haeldeliweg 4, CH-8044 Zurich, Switzerland b Institute of Pathology, University Hospital,…

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Eighth International Mesothelioma Interest Group

Oncogene. 2007 May 14; [Epub ahead of print] [Link] M Carbone1, S M Albelda2, V C Broaddus3, R M Flores4, G Hillerdal5, M-C Jaurand6,7, K Kjaerheim8, H I Pass9, B Robinson10 and A Tsao11 1Thoracic Oncology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA 2Thoracic Oncology Research Laboratory, University of Pennsylvania Medical…

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