Causation
Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure
Journal of Environmental Pathology, Toxicology, and Oncology 2024 [Link] Tunç Tuncel, Güntülü Ak, Hasan Veysi Güneş, Muzaffer Metintaş Abstract Malignant pleural mesothelioma (MPM) is a rare type of cancer, and its main risk factor is exposure to asbestos. Accordingly, our knowledge of the genomic structure of an MPM tumor is limited when compared to other…
Read MoreA gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma
Cell & Bioscience 2024 March 10 [Link] Jun Liu, Yuwei Lu, Yifan Liu, Wei Zhang, Shuyuan Xian, Siqiao Wang, Zixuan Zheng, Ruoyi Lin, Minghao Jin, Mengyi Zhang, Weijin Qian, Jieling Tang, Bingnan Lu, Yiting Yang, Zichang Liu, Mingyu Qu, Haonan Ma, Xinru Wu, Zhengyan Chang, Jie Zhang, Yuan Zhang Abstract Background: Malignant mesothelioma is a…
Read MorePleural mesothelioma (PMe): The evolving molecular knowledge of a rare and aggressive cancer
Molecular Oncology 2024 March 8 [Link] Manuel Rigon, Luciano Mutti, Michelangelo Campanella Abstract Mesothelioma is a type of late-onset cancer that develops in cells covering the outer surface of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining of the lungs, making pleural mesothelioma (PMe) the most common and…
Read MoreThe Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells
Genes 2024 February 1 [Link] Stefania Oliveto, Paolo Ritter, Giorgia Deroma, Annarita Miluzio, Chiara Cordiglieri, Mauro Roberto Benvenuti, Luciano Mutti, Manuela Teresa Raimondi, Stefano Biffo Abstract Malignant mesothelioma is a type of cancer that affects the mesothelium. It is an aggressive and deadly form of cancer that is often caused by exposure to asbestos. At…
Read MorePleural Mesothelioma: Advances in Blood and Pleural Biomarkers
Journal of Clinical Medicine 2023 November 9 [Link] Claudio Sorino, Michele Mondoni, Giampietro Marchetti, Sergio Agati, Riccardo Inchingolo, Federico Mei, Sara Flamini, Filippo Lococo, David Feller-Kopman Abstract Pleural mesothelioma (PM) is a type of cancer that is highly related to exposure to asbestos fibers. It shows aggressive behavior, and the current therapeutic approaches are usually…
Read MoreThe Interplay Between the Immune System, Tumor Suppressor Genes, and Immune Senescence in Mesothelioma Development and Response to Immunotherapy
Journal of Thoracic Oncology 2023 November 23 [Link] Andre E Nel, Elizabeth N Pavlisko, Victor L Roggli Abstract Despite efforts to ban asbestos mining and manufacturing, mesothelioma deaths in the United States have remained stable at approximately 2500 cases annually. This trend is not unique to the United States but is also a global phenomenon,…
Read MoreDeciphering signaling pathway interplay via miRNAs in malignant pleural mesothelioma
Pathology Research and Practice 2023 December [Link] Aya Salman, Sherif S Abdel Mageed, Doaa Fathi, Mahmoud A Elrebehy, Ahmed I Abulsoud, Shereen Saeid Elshaer, Emad Gamil Khidr, Tohada M Al-Noshokaty, Reem Khaled, Nehal I Rizk, Mohammed S Elballal, Ghadir A Sayed, Mai A Abd-Elmawla, Manar Mohammed El Tabaa, Osama A Mohammed, Alaa Ashraf, Ahmed A…
Read MoreThe role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples
Frontiers in Public Health 2023 October 24 [Link] Pierangela Grignani, Silvia Damiana Visonà, Maria Vittoria Fronda, Paola Borrelli, Maria Cristina Monti, Barbara Bertoglio, Adelaide Conti, Paolo Fattorini, Carlo Previderè Abstract Asbestos-related diseases still represent a major public health problem all over the world. Among them, malignant mesothelioma (MM) is a poor-prognosis cancer, arising from the…
Read MorePreventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma
Journal of Translational Medicine 2023 October 25 [Link] Michele Carbone, Michael Minaai, Yasutaka Takinishi, Ian Pagano, Haining Yang Abstract Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to the…
Read MoreHMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma
Proceedings of the National Academy of Sciences of the United States of America 2023 September 26 [Link] Joelle S Suarez, Flavia Novelli, Keisuke Goto, Michiko Ehara, Mika Steele, Jin-Hee Kim, Alicia A Zolondick, Jiaming Xue, Ronghui Xu, Mai Saito, Sandra Pastorino 1, Michael Minaai, Yasutaka Takanishi, Mitsuru Emi, Ian Pagano, Andrew Wakeham, Thorsten Berger, Harvey…
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