Epithelioid
Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapy
Molecular Cancer 2023 July 17 [Link] F Torricelli, B Donati, F Reggiani, V Manicardi, S Piana, R Valli, F Lococo, Alessia Ciarrocchi Abstract Background: Malignant Pleural Mesothelioma (MPM) is a dreadful disease escaping the classical genetic model of cancer evolution and characterized by wide heterogeneity and transcriptional plasticity. Clinical evolution of MPM is marked by…
Read MoreAsbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma
Frontiers in Toxicology 2023 June 27 [Link] Pooyeh Farahmand, Katarina Gyuraszova, Claire Rooney, Ximena L Raffo-Iraolagoitia, Geeshath Jayasekera, Ann Hedley, Emma Johnson, Tatyana Chernova, Gaurav Malviya, Holly Hall, Tiziana Monteverde, Kevin Blyth, Rodger Duffin, Leo M Carlin, David Lewis, John Le Quesne, Marion MacFarlane, Daniel J Murphy Abstract Hypothesis: Asbestos-driven inflammation contributes to malignant pleural…
Read MoreAdjuvant dendritic cell-based immunotherapy after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with malignant peritoneal mesothelioma: a phase II clinical trial
Journal for Immunotherapy of Cancer 2023 August [Link] Michelle V Dietz, Katrien L A Quintelier, Job P van Kooten, Nadine L de Boer, Madelief Vink, Alexandra R M Brandt-Kerkhof, Cornelis Verhoef, Yvan Saeys, Joachim G J V Aerts, Marcella Willemsen, Sofie Van Gassen, Eva V E Madsen Abstract Background: Malignant peritoneal mesothelioma (MPM) is an…
Read MoreAn anoikis-based gene signature for predicting prognosis in malignant pleural mesothelioma and revealing immune infiltration
Journal of Cancer Research and Clinical Oncology 2023 July 8 [Link] Jiaxin Shi, Bo Peng, Xiang Zhou, Chenghao Wang, Ran Xu, Tong Lu, Xiaoyan Chang, Zhiping Shen, Kaiyu Wang, Chengyu Xu, Linyou Zhang Abstract Introduction: Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant tumor. Anoikis is a particular type of programmed apoptosis brought on by…
Read MoreComparison of video-assisted pleurectomy/decortication surgery plus hyperthermic intrathoracic chemotherapy with VATS talc pleurodesis for the treatment of malignant pleural mesothelioma: A pilot study
Heliyon 2023 May 25 [Link] Marcello Migliore, Maria Fiore, Tommaso Filippini, Rosario Tumino, Mara Sabbioni, Corrado Spatola, Riccardo Polosa, Paolo Vigneri, Marco Nardini, Sergio Castorina, Francesco Basile, Margherita Ferrante Abstract Hyperthermic intrathoracic chemotherapy (HITHOC) adjunct to surgery for Malignant Pleural Mesothelioma (MPM) has no definite role. The primary objective of this pilot-trial was to evaluate…
Read MoreCytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) for peritoneal mesothelioma: Canadian practices and outcomes
Journal of Surgical Oncology 2023 May 30 [Link] Melina Deban, Kadhim Taqi, Gregory C Knapp, Mikael Soucisse, Matt Curry, Lucas Sidéris, Pierre Dubé, Maher Al Khaldi, Nicole Jedrzejko, Geoff Porter, Carman Giacomantonio, Trevor Hamilton, Andrea MacNeill, Lloyd Mack, Antoine Bouchard-Fortier Abstract Introduction: Peritoneal mesothelioma (PM) is a rare malignancy originating from the peritoneal lining. Cytoreductive…
Read MoreEuropean Epidemiology of Pleural Mesothelioma – Real-life data from a joint analysis of the Mesoscape database of the European Thoracic Oncology Platform and the European Society of Thoracic Surgery Mesothelioma database
Journal of Thoracic Oncology 2023 June 23 [Link] Isabelle Opitz, Andrea Bille, Urania Dafni, Kristiaan Nackaerts, Luca Ampollini, Marc de Perrot, Luka Brcic, Ernest Nadal, Konstantinos Syrigos, Steven G Gray, Joachim Aerts, Alessandra Curioni-Fontecedro, Jan H Rüschoff, Kim Monkhorst, Birgit Weynand, Enrico Maria Silini, Fatemeh Bavaghar-Zaeimi, Marko Jakopovic, Roger Llatjos, Sotirios Tsimpouki, Stephen P Finn,…
Read MoreReliability of assessing morphologic features with prognostic significance in cytology specimens of epithelioid diffuse pleural mesothelioma and implications for cytopathology reporting
Cancer Cytopathology 2023 May 1 [Link] Yan Li, Abeer M Salama, Marina K Baine, Francis M Bodd, Michael D Offin, Natasha Rekhtman, Marjorie G Zauderer, William D Travis, Prasad S Adusumilli, Jennifer L Sauter Abstract Background: The World Health Organization incorporates morphologic features with prognostic significance in the 2021 classification of epithelioid diffuse pleural mesothelioma…
Read MoreSequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts
Heliyon 2023 April 11 [Link] Zhenghua Zhang, Shasha Shen, Jiyao Ma, Tianfu Qi, Chao Gao, Xiong Hu, Dan Han, Yilong Huang Abstract Objective: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential…
Read MoreEpidemiological, therapeutic, and survival trends in malignant pleural mesothelioma: A review of the National Cancer Database
Cancer Medicine 2023 April 16 [Link] Patrick Bou-Samra, Austin Chang, Feredun Azari, Gregory Kennedy, Alix Segil, Emily Guo, Melina Marmarelis, Corey Langer, Sunil Singhal Abstract Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer of the cells lining the pleural cavity with a low overall incidence. The National Cancer Database (NCDB) released in August 2022…
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