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Curated Journal Articles on Mesothelioma

Category Archives: Trimodality or Mulitmodality Therapy

Using a combination of treatments, such as chemotherapy, surgery, and radiation. Commonly, preoperative chemotherapy and postoperative radiation.

Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma

Expert Opinion of Investigational Drugs 2017 July 6 [Epub ahead of print] [Link] Guazzelli A, Bakker E, Tian K, Demonacos C, Krstic-Demonacos M, Mutti L Abstract INTRODUCTION: Malignant mesothelioma is a rare and lethal malignancy primarily affecting the pleura and peritoneum. Mesothelioma incidence is expected to increase worldwide and current treatments remain ineffective, leading to […]

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Surgery as part of radical treatment for malignant pleural mesothelioma

Current Opinion in Pulmonary Medicine 2017 June [Link] Waller DA, Tenconi S Abstract PURPOSE OF REVIEW: To review the latest developments in surgery for malignant pleural mesothelioma both in patient selection, surgical technique, and strategy. RECENT FINDINGS: The International Association for the Study of Lung Cancer mesothelioma staging project has produced data to inform the […]

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Induction chemotherapy vs post-operative adjuvant therapy for malignant pleural mesothelioma

Expert review of respiratory medicine 2017 June [Epub ahead of print] [Link] Marulli G, Faccioli E, Bellini A, Mammana M, Rea F Abstract INTRODUCTION: Malignant pleural mesothelioma (MPM) is an aggressive neoplasia. Multidisciplinary treatments, including the association of induction and/or adjuvant therapeutic regimens with surgery, have been reported to give encouraging results. Current therapeutic options […]

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Induction chemotherapy, extrapleural pneumonectomy and adjuvant radiotherapy for malignant pleural mesothelioma

European Journal of Cardio-Thoracic Surgery 2017 May [Epub ahead of print] [Link] Casiraghi M, Maisonneuve P, Brambilla D, Solli P, Galetta D, Petrella F, Piperno G, De Marinis F, Spaggiari L Abstract OBJECTIVES: While the best approach to malignant pleural mesothelioma has yet to be demonstrated, surgery remains the mainstay of treatment. We analysed a […]

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Management of malignant pleural mesothelioma-part 2: therapeutic approaches : Consensus of the Austrian Mesothelioma Interest Group (AMIG)

Wiener Klinische Wochenschrift 2016 July 25 [E pub ahead of print] [Link] Hoda MA, Klikovits T, Arns M, Dieckmann K, Zöchbauer-Müller S, Geltner C, Baumgartner B, Errhalt P, Machan B, Pohl W, Hutter J, Eckmayr J, Studnicka M, Flicker M, Cerkl P, Klepetko W Abstract Treatment of malignant pleural mesothelioma (MPM) depends on performance status […]

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Induction Therapy for Mesothelioma

Seminars in Thoracic and Cardiovascular Surgery 2015 Summer [Link] Opitz I, Weder W. Abstract One particular approach of multimodality treatment for mesothelioma is induction therapy followed by surgery. Among its several advantages, the most important is downstaging of the tumor into a resectable stage, although morbidity and mortality might be increased. In this article we […]

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Management of recurrence after initial surgery for malignant pleural mesothelioma: a mini-review

Future Oncology 2015 November [Link] Halezeroğlu S, Migliore M. Abstract Recurrence after surgery in the multimodality therapy for malignant pleural mesothelioma is a common problem. As the majority of patients experience not only local but also distant metastases, a systemic treatment strategy in addition to local control measures remains necessary. Nevertheless, none of the chemotherapy […]

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Relapse pattern and second-line treatment following multimodality treatment for malignant pleural mesothelioma

European Journal of Cardiothoracic Surgery 2015 November 20 [Epub ahead of print] [Link] Kostron A, Friess M, Crameri O, Inci I, Schneiter D, Hillinger S, Stahel R, Weder W, Opitz I. Abstract Objectives To analyse the relapse pattern and influence of second-line treatment after recurrence of malignant pleural mesothelioma (MPM) in patients who had previously […]

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Biologic therapy and gene therapy in the multimodality treatment of malignant pleural mesothelioma

Annals of Translational Medicine 2015 October [Link] Viti A, Bertolaccini L, Terzi A. Abstract The last years have witnessed an abrupt paradigm shift in cancer treatment owing to the discoveries concerning the relationships between the immune system and neoplastic cells. In the field of malignant mesothelioma, which, despite painstaking efforts, remains an incurable form of […]

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Trimodality strategy for treating malignant pleural mesothelioma: results of a feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation (Japan Mesothelioma Interest Group 0601 Trial)

International Journal of Clinical Oncology 2015 November 17 [Epub ahead of print] [Link] Hasegawa S, Okada M, Tanaka F, Yamanaka T, Soejima T, Kamikonya N, Tsujimura T, Fukuoka K, Yokoi K, Nakano T. Abstract Purpose We conducted a prospective multi-institutional study to determine the feasibility of trimodality therapy (TMT) comprising induction chemotherapy followed by extrapleural […]

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