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Curated Journal Articles on Mesothelioma

Category Archives: Trimodality or Mulitmodality Therapy

Using a combination of treatments, such as chemotherapy, surgery, and radiation. Commonly, preoperative chemotherapy and postoperative radiation.

New Concepts in the Treatment of Malignant Pleural Mesothelioma

Annual Review of Medicine 2017 October [Epub ahead of print] [Link] Wald O, Sugarbaker DJ Abstract Malignant pleural mesothelioma (MPM) is a highly aggressive and generally incurable cancer. Current anti-MPM chemotherapy-based treatments are only marginally effective, and long-term survival remains an unmet goal. Nonetheless, in selected cases, personalized surgery-based multimodality treatments (MMT) have been shown […]

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A Randomized Phase II Trial of Adjuvant Galinpepimut-S, WT-1 Analog Peptide Vaccine, after Multimodality Therapy for Patients with Malignant Pleural Mesothelioma

Clinical Cancer Research 2017 September [Epub ahead of print][Link] Zauderer MG, et.al. Abstract PURPOSE: Determine the 1-year progression-free survival (PFS) among patients with malignant pleural mesothelioma (MPM) receiving the WT1 peptide vaccine galinpepimut-S after multimodality therapy vs those receiving control adjuvants. PATIENTS AND METHODS: This double-blind, controlled, two center phase II trial randomized MPM patients […]

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Long-Term Survival Outcomes of Cancer-Directed Surgery for Malignant Pleural Mesothelioma: Propensity Score Matching Analysis

Journal of Clinical Oncology 2017 August [Epub ahead of print] [Link] Nelson DB, Rice DC, Niu J, Atay S, Vaporciyan AA, Antonoff M, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Tsao A, Gomez D, Giordano SH, Mehran R, Sepesi B Abstract Purpose Small observational studies have shown a survival advantage to undergoing cancer-directed surgery […]

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Long-Term Survival Outcomes of Cancer-Directed Surgery for Malignant Pleural Mesothelioma: Propensity Score Matching Analysis

Journal of Clinical Oncology 2017 August [Epub ahead of print] [Link] Nelson DB, Rice DC, Niu J, Atay S, Vaporciyan AA, Antonoff M, Hofstetter WL, Walsh GL, Swisher SG, Roth J, Tsao A, Gomez D, Giordano SH, Mehran R, Sepesi B Abstract Purpose Small observational studies have shown a survival advantage to undergoing cancer-directed surgery […]

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Intraoperative adjuncts for malignant pleural mesothelioma

Translational Lung Cancer Research 2017 June [Link] Chan WH, Sugarbaker DJ, Burt BM Abstract Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic […]

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Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma

Expert Opinion of Investigational Drugs 2017 July 6 [Epub ahead of print] [Link] Guazzelli A, Bakker E, Tian K, Demonacos C, Krstic-Demonacos M, Mutti L Abstract INTRODUCTION: Malignant mesothelioma is a rare and lethal malignancy primarily affecting the pleura and peritoneum. Mesothelioma incidence is expected to increase worldwide and current treatments remain ineffective, leading to […]

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Surgery as part of radical treatment for malignant pleural mesothelioma

Current Opinion in Pulmonary Medicine 2017 June [Link] Waller DA, Tenconi S Abstract PURPOSE OF REVIEW: To review the latest developments in surgery for malignant pleural mesothelioma both in patient selection, surgical technique, and strategy. RECENT FINDINGS: The International Association for the Study of Lung Cancer mesothelioma staging project has produced data to inform the […]

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Induction chemotherapy vs post-operative adjuvant therapy for malignant pleural mesothelioma

Expert review of respiratory medicine 2017 June [Epub ahead of print] [Link] Marulli G, Faccioli E, Bellini A, Mammana M, Rea F Abstract INTRODUCTION: Malignant pleural mesothelioma (MPM) is an aggressive neoplasia. Multidisciplinary treatments, including the association of induction and/or adjuvant therapeutic regimens with surgery, have been reported to give encouraging results. Current therapeutic options […]

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Induction chemotherapy, extrapleural pneumonectomy and adjuvant radiotherapy for malignant pleural mesothelioma

European Journal of Cardio-Thoracic Surgery 2017 May [Epub ahead of print] [Link] Casiraghi M, Maisonneuve P, Brambilla D, Solli P, Galetta D, Petrella F, Piperno G, De Marinis F, Spaggiari L Abstract OBJECTIVES: While the best approach to malignant pleural mesothelioma has yet to be demonstrated, surgery remains the mainstay of treatment. We analysed a […]

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Management of malignant pleural mesothelioma-part 2: therapeutic approaches : Consensus of the Austrian Mesothelioma Interest Group (AMIG)

Wiener Klinische Wochenschrift 2016 July 25 [E pub ahead of print] [Link] Hoda MA, Klikovits T, Arns M, Dieckmann K, Zöchbauer-Müller S, Geltner C, Baumgartner B, Errhalt P, Machan B, Pohl W, Hutter J, Eckmayr J, Studnicka M, Flicker M, Cerkl P, Klepetko W Abstract Treatment of malignant pleural mesothelioma (MPM) depends on performance status […]

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