Three Decades of Malignant Pleural Mesothelioma: An Academic Center Experience

Clinical Lung Cancer 2021 March 27 [Link] Abdullah Nasser, Andrew Baird, Mathieu D Saint-Pierre, Kayvan Amjadi, Scott Laurie, Paul Wheatley-Price Abstract Background: Malignant pleural mesothelioma (MPM) remains a challenging disease to manage. In the past few decades, extrapleural pneumonectomy (EPP), pemetrexed-based chemotherapy, and indwelling pleural catheters were introduced to MPM care with variable levels of…

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Outcomes of Conversion to Extrapleural Pneumonectomy from Pleurectomy/Decortication for Malignant Pleural Mesothelioma

Seminars in Thoracic and Cardiovascular Surgery 2021 February 17 [Link] Akifumi Nakamura, Masaki Hashimoto, Seiji Matsumoto, Nobuyuki Kondo, Takashi Kijima, Seiki Hasegawa Abstract In recent years, there has been a shift from extrapleural pneumonectomy (EPP) toward pleurectomy/decortication (P/D) as the preferred surgical technique. However, we occasionally encounter difficult cases wherein visceral pleurectomy requires conversion to…

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Outcomes of Conversion to Extrapleural Pneumonectomy from Pleurectomy/Decortication for Malignant Pleural Mesothelioma

Seminars in Thoracic and Cardiovascular Surgery 2021 February 17 [Link] Akifumi Nakamura, Masaki Hashimoto, Seiji Matsumoto, Nobuyuki Kondo, Takashi Kijima, Seiki Hasegawa Abstract In recent years, there has been a shift from extrapleural pneumonectomy (EPP) toward pleurectomy/decortication (P/D) as the preferred surgical technique. However, we occasionally encounter difficult cases wherein visceral pleurectomy requires conversion to…

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Pleurectomy Decortication in the Treatment of Malignant Pleural Mesothelioma: Encouraging Results and Novel Prognostic Implications Based on Experience in 355 Consecutive Patients

Annals of Surgery 2020 December 3 [Link] Moshe Lapidot, Ritu R Gill, Emanuele Mazzola, Samuel Freyaldenhoven, Scott J Swanson, Michael T Jaklitsch, David J Sugarbaker, Raphael Bueno Abstract Objective: We report a series of 355 consecutive patients treated over 9 years in a single institution with intended PDC. Background: Surgery for MPM has shifted from…

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Diagnostic Laparoscopy Improves Staging of Malignant Pleural Mesothelioma with Routine PET Imaging

Annals of Thoracic Surgery 2020 December 1 [Link] R Taylor Ripley, Nihanth Palivela, Shawn S Groth, Eugene A Choi, Lorraine D Cornwell, Phillip W Carrott, George Van Buren, Taylor G Splawn, David J Sugarbaker, Bryan M Burt Abstract Background: With a multimodal treatment strategy, cytoreductive surgery extends survival in malignant pleural mesothelioma. Improving the accuracy…

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Diagnostic Laparoscopy Improves Staging of Malignant Pleural Mesothelioma with Routine PET Imaging

Annals of Thoracic Surgery 2020 December 1 [Link] R Taylor Ripley, Nihanth Palivela, Shawn S Groth, Eugene A Choi, Lorraine D Cornwell, Phillip W Carrott, George Van Buren, Taylor G Splawn, David J Sugarbaker, Bryan M Burt Abstract Background: With a multimodal treatment strategy, cytoreductive surgery extends survival in malignant pleural mesothelioma. Improving the accuracy…

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Prolonged survival after multimodal therapy for pleural mesothelioma: Don’t give up the follow-up. A case report

Annals of Medicine and Surgery 2020 November 11 [Link] Julien Guinde, Bertrand Chollet, Sophie Laroumagne, HervĂ© Dutau, Philippe Astoul Abstract Malignant Pleural mesothelioma (MPM) is a rare disease which is associated with a poor prognosis. Front line chemotherapy represents the cornerstone in the management of MPM, and the place of radical surgery is controversial and…

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Progress in the understanding of the immune microenvironment and immunotherapy in malignant pleural mesothelioma

Current Drug Targets 2020 July 18 [Link] Lei Cheng, Li Na, Xiao-Ling Xu, Wei-Min Mao Abstract Malignant pleural mesothelioma (MPM) is a remarkably aggressive thoracic malignancy with a limited survival of only 5-12 months. However, MPM still remains unresponsive to conventional standards of treatment, including pleurectomy and decortication, extrapleural pneumonectomy for resectable disease with or…

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