Dosimetric Correlates of Pulmonary Toxicity in Patients with Malignant Pleural Mesothelioma Receiving Radiation Therapy to the Intact Lungs.

Practical Radiation Oncology 2019 January 14 [Link] Thompson MR1, Dumane VA1, Lazarev SA1, Zia Y2, Rosenzweig KE3 INTRODUCTION: We aimed to determine dose-volume constraints that correlate with severe (grade ≥3) radiation pneumonitis (RP) in patients diagnosed with malignant pleural mesothelioma (MPM), treated using volumetric modulated arc therapy (VMAT). METHODS: Data from 40 patients with MPM who underwent pleurectomy decortication (P/D) and…

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Proton Therapy for Malignant Pleural Mesothelioma: A Three Case Series Describing the Clinical and Dosimetric Advantages of Proton-Based Therapy

Cureus 2017 September [Link] Lee H, Zeng J, Bowen SR, Rengan R Abstract Malignant pleural mesothelioma (MPM) is a malignancy of the pleural cavity that typically presents at an advanced stage. Due to its large, circumferential clinical target volume (CTV) and proximity to major structures, including the heart and contralateral lung, delivering hemithoracic intensity-modulated radiotherapy…

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Functional image guided radiation therapy planning in volumetric modulated arc therapy for patients with malignant pleural mesothelioma

Advances in Radiation Oncology [2017 February] [Link] Doi Y, Kimura T, Nakashima T, Takeuchi Y, Takahashi I, Nishibuchi I, Murakami Y, Nagata Y Abstract PURPOSE: To investigate the incorporation of functional lung image-derived low-attenuation area (LAA) based on 4-dimensional computed tomography (4D-CT) in volumetric modulated arc therapy (VMAT) planning for patients with malignant pleural mesothelioma…

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A pilot study of volumetric-modulated arc therapy for malignant pleural mesothelioma

Journal of Applied Clinical Medical Physics 2016 March [Link] Runxiao L1, Yankun C1, Lan W Abstract Malignant pleural mesothelioma (MPM) is an extremely difficult disease to treat. This pilot study investigates the feasibility of using volumetric-modulated arc therapy (VMAT) for malignant pleural mesothelioma (MPM), and compares VMAT to static field intensity-modulated radiotherapy (IMRT) for five…

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A pilot study of volumetric-modulated arc therapy for malignant pleural mesothelioma

Journal of applied clinical medical physics / American College of Medical Physics. 2016 Mar 8;17(2):5980. doi: .[Link] Runxiao L1, Yankun C, Lan W. Abstract Malignant pleural mesothelioma (MPM) is an extremely difficult disease to treat. This pilot study investigates the feasibility of using volumetric-modulated arc therapy (VMAT) for malignant pleural mesothelioma (MPM), and compares VMAT…

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