Multi-Institutional Patterns of Use of Tumor-Treating Fields for Patients with Malignant Pleural Mesothelioma

Current Oncology 2023 May 23 [Link] Tugce Kutuk, Joshua M Walker, Matthew T Ballo, Robert B Cameron, Jean Bustamante Alvarez, Sheema Chawla, Eric Luk, Deepti Behl, Alan Dal Pra, Neil Morganstein, Tamer Refaat, Arshin Sheybani, Christian Squillante, Jun Zhang, Rupesh Kotecha Abstract (1) Background: The objective of this analysis was to evaluate the device usage…

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A Drug Screening Revealed Novel Potential Agents against Malignant Pleural Mesothelioma

Cancers 2022 May 20 [Link] Irene Dell’Anno, Alessandra Melani, Sarah A Martin, Marcella Barbarino, Roberto Silvestri, Monica Cipollini, Antonio Giordano, Luciano Mutti, Andrea Nicolini, Luca Luzzi, Raffaele Aiello, Federica Gemignani, Stefano Landi Abstract The lack of effective therapies remains one of the main challenges for malignant pleural mesothelioma (MPM). In this perspective, drug repositioning could…

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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Journal of Visualized Experiments 2022 April 21 [Link] Tamara M Griffiths, Carlos Ramos, Cara L Haymaker Abstract Current methodologies for the expansion of primary tumor cell lines from rare tumor types are lacking. This protocol describes methods to expand primary tumor cells from surgically resected, malignant pleural mesothelioma (MPM) by providing a complete overview of…

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Feasibility of Tumor Treating Fields with Pemetrexed and Platinum-Based Chemotherapy for Unresectable Malignant Pleural Mesothelioma: Single-Center, Real-World Data

Cancers 2022 April 16 [Link] Tugce Kutuk, Haley Appel, Maria Carolina Avendano, Federico Albrecht, Paul Kaywin, Suyen Ramos, Melanie E Suarez-Murias, Minesh P Mehta, Rupesh Kotecha Abstract Purpose: The objectives of this study were to evaluate the implementation, device usage rates, clinical outcomes, and treatment-related toxicities associated with TTFields and pemetrexed plus platinum-based chemotherapy in…

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Exhaled breath to screen for malignant pleural mesothelioma: a validation study

The European Respiratory Journal 2017 December 21 [Link] Lamote K, Vynck M, Thas O, Van Cleemput J, Nackaerts K, van Meerbeeck JP Abstract Malignant pleural mesothelioma (MPM) is predominantly caused by asbestos exposure and has a poor prognosis. Breath contains volatile organic compounds (VOCs) and can be explored as an early detection tool. Previously, we…

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Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM)

Cancers 2017 September [Link] Klampatsa A, Haas AR, Moon EK, Albelda SM Abstract Cancer immunotherapy has now become a recognized approach to treating cancers. In addition to checkpoint blockade, adoptive T cell transfer (ACT) using chimeric antigen receptors (CARs) has shown impressive clinical outcomes in leukemias and is now being explored in solid tumors. CARs…

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Malignant Pleural Mesothelioma: State of the art and advanced cell therapy

European Journal of Medicinal Chemistry 2017 August [Epub ahead of print] [Link] Facchetti G, Petrella F, Spaggiari L, Rimoldi I Abstract Malignant Pleural Mesothelioma (MPM) is an aggressive malignancy highly resistant to chemotherapy, with a response rate of 20% of patients and for this reason an efficient treatment is still a challenge. Platinum-based chemotherapy in…

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Intraoperative adjuncts for malignant pleural mesothelioma

Translational Lung Cancer Research 2017 June [Link] Chan WH, Sugarbaker DJ, Burt BM Abstract Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic…

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