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Curated Journal Articles on Mesothelioma

Category Archives: Gene Therapy

Magnetic nanoparticles-based therapy for malignant mesothelioma

Romanian Journal of Morphology and Embryology [2017] [Link] Mîndrilă I, Buteică SA, Mihaiescu DE, Burada F, Mîndrilă B, Predoi MC, Pirici I, Fudulu A, Croitoru O Abstract This work was aimed to analyze the versatility of the chick embryo chorioallantoic membrane (CAM) as in vivo model for the study of the malignant pleural mesothelioma (MPM) […]

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Targeting the epigenome in malignant pleural mesothelioma

Translational Lung Cancer Research 2017 June [Link] McLoughlin KC, Kaufman AS, Schrump DS Abstract Malignant pleural mesotheliomas (MPM) are notoriously refractory to conventional treatment modalities. Recent insights regarding epigenetic alterations in MPM provide the preclinical rationale for the evaluation of novel combinatorial regimens targeting the epigenome in these neoplasms.

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Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers

Discovery Medicine 2017 May [Link Rimkus T, Sirkisoon S, Harrison A, Lo HW Abstract Tumor suppressor candidate 2 (TUSC2, also known as FUS1) was identified in 2000 as a candidate tumor suppressor gene located in a region on chromosome 3p21.3 that is homozygously deleted in some lung and breast cancers. The deletion is rare in […]

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Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma

Expert Opinion of Investigational Drugs 2017 July 6 [Epub ahead of print] [Link] Guazzelli A, Bakker E, Tian K, Demonacos C, Krstic-Demonacos M, Mutti L Abstract INTRODUCTION: Malignant mesothelioma is a rare and lethal malignancy primarily affecting the pleura and peritoneum. Mesothelioma incidence is expected to increase worldwide and current treatments remain ineffective, leading to […]

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Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

BMC Cancer 2017 June 2 [Link] Sneddon S, Patch AM, Dick IM, Kazakoff S, Pearson JV, Waddell N, Allcock RJN, Holt RA, Robinson BWS, Creaney J Abstract BACKGROUND: Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively […]

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A Subset of Malignant Mesotheliomas in Young Adults are Associated With Recurrent EWSR1/FUS-ATF1 Fusions

The American Journal of Surgical Pathology 2017 May 12 [Epub ahead of print] [Link] Desmeules P, Joubert P, Zhang L, Al-Ahmadie HA, Fletcher CD, Vakiani E, Delair DF, Rekhtman N, Ladanyi M, Travis WD, Antonescu CR Abstract Malignant mesothelioma (MM) is a rare, aggressive tumor often associated with asbestos exposure and characterized by complex genetic […]

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Transcriptomic Analysis of the Claudin Interactome in Malignant Pleural Mesothelioma: Evaluation of the Effect of Disease Phenotype, Asbestos Exposure, and CDKN2A Deletion Status.

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Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma.

Oncoimmunology 2017 January [Link] Kiyotani K, Park JH, Inoue H, Husain A, Olugbile S, Zewde M, Nakamura Y, Vigneswaran WT Abstract To investigate the link between the genomic landscape of cancer cells and immune microenvironment in tumor tissues, we characterized somatic mutations and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM), including mutation/neoantigen load, spatial […]

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Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir

Toxicology In Vitro Journal 2017 February [Epub ahead of print] [Link] Catalani S, Palma F, Battistelli S, Nuvoli B, Galati R, Benedetti S Abstract Besides its well-recognized antiviral activity, Cidofovir (CDV) has been shown to exert anticancer properties both within in vitro and in vivo models. The aim of this study was to evaluate the […]

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Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma

International Journal of Oncology 2017 February 9 [Epub ahead of print] [Link] Cregan S, Breslin M, Roche G, Wennstedt S, MacDonagh L, Albadri C, Gao Y, O’Byrne KJ, Cuffe S, Finn SP, Gray SG Abstract Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The […]

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