Determining Efficacy
Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial
JAMA Oncology 2017 January [Link] Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S, Shamash J, Phillips MM, Luong P, Payne S, Hillman P, Ellis S, Szyszko T, Dancey G, Butcher L, Beck S, Avril NE, Thomson J, Johnston A, Tomsa M, Lawrence C, Schmid P, Crook T,…
Read MorePercutaneous Cryoablation for the Treatment of Recurrent Malignant Pleural Mesothelioma: Safety, Early-Term Efficacy, and Predictors of Local Recurrence
Journal of Vascular and Interventional Radiology 2016 December 12 [Epub ahead of print] [Link] Abtin F, Quirk MT, Suh RD, Hsu W, Han SX, Kim GJ, Genshaft S, Sandberg JK, Olevsky O, Cameron RB Abstract PURPOSE: To determine safety and early-term efficacy of CT-guided cryoablation for treatment of recurrent mesothelioma and assess risk factors for…
Read MoreIntrapleural Adenoviral-mediated Endothelial Cell Protein C Receptor Gene Transfer Suppresses the Progression of Malignant Pleural Mesothelioma in a Mouse Model
Scientific Reports 2016 November 11 [Link] Keshava S, Rao LV, Pendurthi UR Abstract Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer with a high mortality rate as it responds poorly to standard therapeutic interventions. Our recent studies showed that expression of endothelial cell protein C receptor (EPCR) in MPM cells suppresses tumorigenicity. The present…
Read MoreExtended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years
The Annals of Thoracic Surgery 2016 November 5 [Epub ahead of print] Link] Friedberg JS, Simone CB 2nd, Culligan MJ, Barsky AR, Doucette A, McNulty S, Hahn SM, Alley E, Sterman DH, Glatstein E, Cengel KA Abstract BACKGROUND: The purpose of this study was to assess survival for patients with malignant pleural mesothelioma (MPM), epithelial…
Read MoreStatin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis
Cancer Letters 2016 October [Epub ahead of print] [Link] Tanaka K, Osada H, Murakami-Tonami Y, Horio Y, Hida T, Sekido Y Abstract Malignant mesothelioma (MM) frequently exhibits Hippo signaling pathway inactivation (HPI) mainly due to NF2 and/or LATS2 mutations, which leads to the activation of YAP transcriptional co-activator. Here, we show antitumor effects of statin…
Read MoreVEGF promoter-based conditionally replicative adenoviruses effectively suppress growth of malignant pleural mesothelioma
Cancer Science 2016 October 26 [Epub ahead of print] [Link] Harada A, Uchino J, Harada T, Nakagaki N, Hisasue J, Fujita M, Takayama K Abstract Malignant mesothelioma (MM) incidence is increasing drastically worldwide as an occupational disease resulting from asbestos exposure. However, no curative treatment for MM of advanced stage is available. Thus, new therapeutic…
Read MoreIntensity-modulated radiotherapy for relapsed malignant pleural mesothelioma
Future Oncology (London, England) 2016 September 21 [Epub ahead of print] [Link] Spatola C, Militello C, Tocco A, Salamone V, Raffaele L, Migliore M, Pagana A, Milazzotto R, Chillura I, Pergolizzi S, Privitera G Abstract The use of novel radiotherapy techniques is widely increasing, allowing clinicians to treat diseases that were previously difficult to treat…
Read MoreUtility and pitfall of Immunohistochemistry in the Differential Diagnosis between Epithelioid Mesothelioma and Poorly Differentiated Lung Squamous Cell Carcinoma
Histopathology 2016 September 2 [Epub ahead of print] [Link] Kushitani K, Amatya VJ, Okada Y, Katayama Y, Mawas AS, Miyata Y, Okada M, Inai K, Kishimoto T, Takeshima Y Abstract AIMS: The aim of this study was to clarify the usefulness of immunohistochemistry in the differential diagnosis of epithelioid mesothelioma with solid growth pattern (solid…
Read MoreMetformin and survival of people with type 2 diabetes and pleural mesothelioma: A population-based retrospective cohort study
Lung Cancer (Amsterdam, Netherlands) 2016 September [Epub 2016 July 20] [Link] Wu H, Walker J, Damhuis RA, Brewster DH, Wild SH; Scottish Diabetes Research Network Epidemiology Group Abstract OBJECTIVES: This study aimed to investigate the effect of metformin on survival of people with type 2 diabetes and pleural mesothelioma. MATERIALS AND METHODS: We conducted a…
Read MorePembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma
BMC Cancer 2016 August 19 Link] Bickel A, Koneth I, Enzler-Tschudy A, Neuweiler J, Flatz L, Früh M Abstract BACKGROUND: Pembrolizumab is an anti- Programmed Death 1 (PD-1) antibody approved in melanoma, non-small cell lung cancer and investigated in malignant pleural mesothelioma. The most frequent immunotherapy related autoimmune reactions include dermatitis, pneumonitis, colitis, hypophysitis, uveitis,…
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