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Curated Journal Articles on Mesothelioma

Category Archives: Ranpirnase (Onconase)

Interaction of onconase with the human ribonuclease inhibitor protein

Biochemical and Biophysical Research Communications. 2008 Dec 12;377(2):512-4. Epub 2008 Oct 16. [Link] Turcotte RF, Raines RT. Medical Scientist Training Program and Biophysics Graduate Program, University of Wisconsin-Madison, Madison, WI 53706, USA. Abstract One of the tightest known protein–protein interactions in biology is that between members of the ribonuclease A superfamily and the ribonuclease inhibitor […]

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The cytotoxic ribonuclease onconase targets RNA interference (siRNA)

Cell Cycle. 2008 Oct;7(20):3258-61. Epub 2008 Oct 25. [Link] Zhao H, Ardelt B, Ardelt W, Shogen K, Darzynkiewicz Z. Department of Pathology, Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA. Abstract Onconase (Onc), a ribonuclease from oocytes of Northern Leopard frogs (Rana pipiens) is cytostatic and cytotoxic to a variety […]

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Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity

Current Pharmaceutical Biotechnology. 2008 Jun;9(3):185-9. Link Rutkoski TJ, Raines RT. Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706 1544, USA. Abstract Onconase® (ONC) is an amphibian member of the bovine pancreatic ribonuclease (RNase A) superfamily that exhibits innate antitumoral activity. ONC has been granted both orphan-drug and fast-track status by the […]

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Onconase and Amphinase, the Antitumor Ribonucleases from Rana pipiens Oocytes

Current Pharmaceutical Biotechnology. 2008 Jun;9(3):215-25. Link Ardelt W, Shogen K, Darzynkiewicz Z. Alfacell Corporation, 300 Atrium Drive, Somerset, NJ 08873, USA. wardelt@alfacell.com Abstract Rana pipiens oocytes contain two homologues of pancreatic ribonuclease A that are cytostatic and cytotoxic to human cancer cells. Extensively studied Onconase is in advanced Phase IIIb clinical trials against malignant mesothelioma, […]

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Antibody-onconase conjugates: cytotoxicity and intracellular routing

Current Pharmaceutical Biotechnology. 2008 Jun;9(3):226-30. Link Rybak SM. Bionanomics, LLC, 411 Walnut Street, Green Cove Springs, FL 32043, USA. rybak@mindspring.com Abstract Onconase, a member of the pancreatic ribonuclease A superfamily, is currently in Phase III clinical trials for treatment of unresectable malignant mesothelioma. The anticancer effect of onconase may relate to its intracellular target, a […]

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Antibody-targeted RNase fusion proteins (immunoRNases) for cancer therapy

Current Pharmaceutical Biotechnology. 2008 Jun;9(3):231-4. Link Krauss J, Arndt MA, Dübel S, Rybak SM. Natinal center for tumor diseases (NCT), Universit6y of Heidelberg, Im Neuenheimer Fild 350, D-69120 Heidleberg, Germany. juergen.krauss@med.uni-heidelberg.de Abstract Ribonucleases (RNases) of the superfamily A exhibit potent antineoplastic activity yet do not mediate appreciable immunogenicity or non-specific toxicity in both animal models […]

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A novel combination: ranpirnase and rosiglitazone induce a synergistic apoptotic effect by down-regulating Fra-1 and Survivin in cancer cells

Molecular Cancer Therapeutics. 2008 Jul 7. [Epub ahead of print] [Link] Ramos-Nino ME, Littenberg B. Departments of Pathology and Medicine and Nursing, University of Vermont, Burlington, Vermont. Abstract Accumulating evidence supports the idea that two known phosphatidylinositol 3′-kinase (PI3K) downstream proteins, Fra-1 and Survivin, are potential targets for cancer therapy. Increased expression of Fra-1, a […]

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Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies

Future Oncology. 2008 Jun;4(3):341-9. [Link] Beck AK, Pass HI, Carbone M, Yang H. New York University School of Medicine, 530 First Ave., Suite 9V, New York, NY 10016, USA, Abstract Ranpirnase, originally isolated from oocytes of the northern leopard frog (Rana pipiens), is a member of the pancreatic RNase A superfamily of ribonucleases. Ranpirnase exerts […]

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Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy

Expert Opinion on Biological Therapy. 2008 Jun;8(6):813-27. [Link] Assaly M, Bongiovanni M, Kumar N, Egger JF, Pelte MF, Genevay M, Finci V, Tschanz E, Pache JC. Department of Pathology, Geneva University Hospital, Geneva, Switzerland. Abstract Background: Ranpirnase, a cytotoxic amphibian ribonuclease, is effective against cancer cells, inducing apoptosis independently of p53 protein. Onconase® (the smallest […]

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Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines

Cancer Biology & Therapy. 2008 Apr 19;7(7) [Epub ahead of print] [Link] Ita M, Halicka HD, Tanaka T, Kurose A, Ardelt B, Shogen K, Darzynkiewicz Z. Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY, 10595; Ita Dental Clinic, Kama-city, Fukuoka 820-0501, Japan. Abstract Onconase (Onc), a ribonuclease from oocytes […]

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