Doxorubicin
Ribonucleases as novel chemotherapeutics: the ranpirnase example
BioDrugs. 2008;22(1):53-8. [Link] Lee JE, Raines RT. Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USADivision of Biology, California Institute of Technology, Pasadena, California, USA. Abstract Ranpirnase, a cytotoxic ribonuclease from the frog Rana pipiens, is the archetype of a novel class of cancer chemotherapeutic agents based on homologs and variants of bovine pancreatic ribonuclease…
Read MoreMulticystic and well-differentiated papillary peritoneal mesothelioma treated by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy (HIPEC)
Annals of Surgical Oncology. 2007 Oct;14(10):2790-7. Epub 2007 Jul 28. [Link] Baratti D, Kusamura S, Nonaka D, Oliva GD, Laterza B, Deraco M. Department of Surgery, National Cancer Institute, Milan, Italy. Abstract Background: Multicystic peritoneal mesothelioma (MPM) and well-differentiated papillary peritoneal mesothelioma (WDPPM) are exceedingly uncommon lesions with uncertain malignant potential and no uniform treatment…
Read MoreLimited cardiotoxicity after extensive thoracic surgery and intraoperative hyperthermic intrathoracic chemotherapy with doxorubicin and cisplatin
Annals of Surgical Oncology. 2007 Oct;14(10):3019-26. Epub 2007 Jul 20. [Link] Eelco de Bree1, Serge van Ruth1, Carl E. Schotborgh2, Paul Baas3 and Frans A. N. Zoetmulder1 (1) Department of Surgical Oncology, Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands (2)Department of Cardiology, Slotervaart Hospital, Amsterdam, The Netherlands (3) Department of Thoracic Oncology,…
Read MoreRanpirnase: amphibian ribonuclease A, P-30 protein-alfacell.
Drugs in R&D. 2007;8(2):120-4. [Link] Abstract Ranpirnase [Onconase] is an amphibian oocyte/early embryo ribonuclease (RNase) of 105 amino acids in length that is capable of controlling tumour growth by degrading RNA within cancer cells, resulting in inhibition of protein synthesis and arresting mitosis in G(1 )phase. It represents the first successful isolation, purification and characterisation…
Read MoreSelenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress
Free Radical Biology and Medicine. 2006 Sep 15;41(6):874-85. Epub 2006 May 10. [Link] Gustav Nilsonnea, Xiaojuan Suna, Christina Nyströma, Anna-Klara Rundlöfa, Aristi Potamitou Fernandesa, Mikael Björnstedta and Katalin Dobra, a, aDepartment of Laboratory Medicine, Karolinska University Hospital, F-46, Karolinska Institutet, S-141 86 Huddinge, Stockholm, Sweden Abstract Malignant mesothelioma cells differentiate into sarcomatoid or epithelioid phenotypes.…
Read MoreCytoreductive surgery followed by intra peritoneal hyperthermic perfusion in the treatment of peritoneal surface malignancies: morbidity and mortality with closed abdomen technique
Journal of Experimental & Clinical Cancer Research. 2003 Dec;22(4 Suppl):207-12. [Link] Truong, Mylene T. MD; Marom, Edith M. MD; Erasmus, Jeremy J. MD Department of Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, TX. Abstract Aims: The purpose of this phase II study was to analyze the morbidity and mortality of cytoreductive surgery…
Read MoreLaparoscopic intraperitoneal hyperthermic chemotherapy for palliation of debilitating malignant ascites
European Journal of Surgical Oncology. 2006 Apr 19; [Epub ahead of print] Accepted 2 March 2006. Available online 21 April 2006. [Link] A. Garofaloa, M. Valleb, J. Garciac and P.H. Sugarbakerc aGeneral–Oncological Surgery, Department of Surgery, S. Camillo Hospital, Rome, Italy bLaparoscopic Unit, Department of Surgery, S. Camillo Hospital, Rome, Italy cProgram in Peritoneal Surface…
Read MoreRanpirnase – an antitumour ribonuclease: its potential role in malignant mesothelioma
Expert Opinion on Biological Therapy. April 2006, Vol. 6, No. 4, Pages 391-399. [Link] Nick Pavlakis†1 & Nicholas J Vogelzang2 1Royal North Shore Hospital, Department of Medical Oncology, St Leonards, NSW 2065, Australia. pavlakis@med.usyd.edu.au 2Nevada Cancer Institute, 10000 W. Charleson Blvd, Suite 260, Las Vegas, NV 89135, USA. nvogelza@nvcancer.org † Author for correspondence Abstract Ranpirnase (Onconase®)…
Read MoreResults of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors
Annals of Oncology. Published online on February 24, 2006 [Link] H. Richly 1, B. F. Henning 2, P. Kupsch 1, K. Passarge 1, M. Grubert 1, R. A. Hilger 1, O. Christensen 3, E. Brendel 3, B. Schwartz 4, M. Ludwig 5, C. Flashar 6, R. Voigtmann 6, M. E. Scheulen 1, S. Seeber 1,…
Read MoreStatins revert doxorubicin resistance via nitric oxide in malignant mesothelioma
International Journal of Cancer. Published Online: 31 Jan 2006. [Link] Chiara Riganti 1, Sara Orecchia 2, Gianpiero Pescarmona 1, Pier Giacomo Betta 2, Dario Ghigo 1 *, Amalia Bosia 1 1Department of Genetics, Biology and Biochemistry, University of Torino, and Research Center on Experimental Medicine (CeRMS), Torino, Italy 2Pathology Unit, Department of Oncology, Azienda Sanitaria…
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