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Curated Journal Articles on Mesothelioma

Category Archives: Chemotherapy

A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma.

Investigational New Drugs 2019 May 7 [Link] van Brummelen EMJ, Levchenko E, Dómine M, Fennell DA, Kindler HL, Viteri S, Gadgeel S, López PG, Kostorov V, Morgensztern D, Orlov S, Zauderer MG, Vansteenkiste JF, Baker-Neblett K, Vasquez J, Wang X, Bellovin DI, Schellens JHM, Yan L, Mitrica I, DeYoung MP, Trigo J Abstract Background Fibroblast […]

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50 Patients with Malignant Mesothelioma of Both the Pleura and Peritoneum: A Single-Institution Experience.

Annals of Surgical Oncology 2019 May 7 [Link] Letica-Kriegel AS, Leinwand JC, Sonett JR, Gorenstein LA, Taub RN, Chabot JA, Kluger MD Abstract BACKGROUND: The most common sites of malignant mesothelioma are the pleura and peritoneum, but little is known about the incidence, prognosis, or treatment of patients with disease in both cavities. Previous series […]

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First-ever Abscopal Effect after Palliative Radiotherapy and Immuno-gene Therapy for Malignant Pleural Mesothelioma.

Cureus 2019 February 20 [Link] Barsky AR, Cengel KA, Katz SI, Sterman DH, Simone CB Abstract Malignant pleural mesothelioma (MPM) is a highly aggressive disease, with few, if any, curative interventions. While there is growing interest in using immunotherapy and immuno-gene therapy to treat MPM, very limited data currently exist for combining these modalities with […]

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Immune checkpoint inhibition for the treatment of mesothelioma.

Expert Opinion on Biological Therapy 2019 May 2 [Link] Nowak AK, McDonnell A, Cook A Abstract Combination chemotherapy is currently standard care for advanced mesothelioma. Checkpoint blockade is a promising new treatment. Areas covered: This review covers clinical use and biomarkers of checkpoint blockade. Medline search used keywords ‘mesothelioma’ combined with ‘checkpoint blockade’ OR ‘PD-L1’ […]

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AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression.

Molecular Oncology 2019 April 29 [Link] Qin Y, Sekine I, Hanazono M, Morinaga T, Fan M, Takiguchi Y, Tada Y, Shingyoji M, Yamaguchi N, Tagawa M Abstract Pemetrexed (PEM) inhibits DNA and RNA synthesis and is currently one of the first-line agents for mesothelioma. PEM suppresses the activities of several enzymes involved in purine and […]

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Management of Malignant Pleural Mesothelioma in the Elderly Population.

Annals of Surgical Oncology 2019 April 22 [Link] Verma V, Wegner RE, Ludmir EB, Hasan S, Colonias A, Grover S, Friedberg JS, Simone CB 2nd Abstract BACKGROUND: The median age at diagnosis for malignant pleural mesothelioma (MPM) is approximately 72 years. Elderly patients pose unique management challenges because of the increased risk of therapy-related toxicities and […]

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Chemotherapy Versus Supportive Care for Unresected Malignant Pleural Mesothelioma.

Clinical Lung Cancer 2019 March 26 [Link] Verma V, Wegner RE, Brooks ED, Miccio JA, Kann BH, Finley GG, Raj MS, Grover S, Mohindra P, Simone CB Abstract BACKGROUND: Management options for unresected malignant pleural mesothelioma (MPM) are largely limited to palliative chemotherapy and best supportive care. This study sought to delineate subgroups most likely […]

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Extra-pleural pneumonectomy in the era of image-guided intensity-modulated radiotherapy.

La Radiologia Medica 2019 April 8 [Link] Trovo M, Franceschini D, Furlan C, Pietrobon F, Vagge S, Farina E, Revelant A, Visani L, Maragna V, Parisi G, Scotti V Abstract PURPOSE: To assess the outcome of malignant pleural mesothelioma patients treated with extra-pleural pneumonectomy (EPP) and adjuvant radiotherapy (RT), using the most advanced radiotherapeutic techniques, […]

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Hyperthermic Intrathoracic Chemotherapy (HITHOC) for Pleural Malignancies-Experience from Indian Centers.

Indian Journal of Surgical Oncology 2019 February [Link] Patel MD, Damodaran D, Rangole A, Shaikh S, Shah K, Bagwade R, Bhatt A Abstract Hyperthermic intrathoracic chemotherapy (HITHOC) has been used in addition to radical surgery for primary and secondary pleural malignancies to improve local control, prolong survival, and improve the quality of life. This study was […]

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Prolonged post-recurrence survival following pleurectomy/decortication for malignant pleural mesothelioma.

Oncology Letters 2019 March [Link] Kai Y, Tsutani Y, Tsubokawa N, Ito M, Mimura T, Miyata Y, Okada M Abstract The present study analyzed surgical results in patients with malignant pleural mesothelioma (MPM) who underwent extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D). Data for 44 patients who achieved macroscopic complete resection following neoadjuvant chemotherapy followed by […]

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