Malignant mesothelioma cells with characteristic intracytoplasmic vacuolization and lipids

Diagnostic Cytopathology 2023 August 15 [Link] Satoshi Morito, Hiroshi Yasui, Tomoo Itoh, Shingo Kamoshida, Hiroyuki Ohsaki Abstract In this brief report, we described some uncommon cytomorphological features of malignant mesothelioma (MM) cells in pleural effusions. The tumor cells exhibited abundant cytoplasmic vacuolization, with presence of single or multiple eccentric nuclei in several cells. In the…

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Malignant Pleural Mesothelioma (MPM) Presenting as Hydropneumothorax

Cureus 2023 July 1 [Link] Masami Kuramochi, Takuma Muraoka, Mayumi Shinonaga, Haruo Ohtani, Setsuo Kuraoka Abstract An 86-year-old man presented with bilateral lower limb edema and was found to have hydropneumothorax on chest radiography. CT revealed a substantial pleural effusion and plaques. The patient had a history of working in a stone workshop, but the…

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A rare presentation of malignant mesothelioma of the tunica vaginalis managed with immunotherapy and review of the literature

Clinical Case Reports 2023 June 22 [Link] Kritika Mishra, Shihab Siddiquee, Anna Rachelle Mislang Abstract Key clinical message: We describe the first case in literature of malignant mesothelioma of the tunica vaginalis that has shown partial response to systemic immunotherapy (ipilimumab-nivolumab) post orchiectomy, warranting further investigation in a trial setting. Abstract: We present a case…

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Comparison of immunohistochemical mesothelial biomarkers in paired biopsies and effusion cytology cell blocks from pleural mesothelioma

Cytopathology 2023 June 19 [Link] Mohammed S I Mansour, Adela Huseinzade, Tomas Seidal, Kim Hejny, Athar Maty, Fereshteh Taheri-Eilagh, Ulrich Mager, Annika Dejmek, Katalin Dobra, Hans Brunnström Abstract Objective: Traditionally, the diagnosis of pleural mesothelioma is based on histological material. Minimally invasive effusion cytology specimens are an alternative that, like biopsies, require ancillary analyses. Validation…

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Intrapleural Anticancer Therapy for Malignant Pleural Diseases: Facts or Fiction?

Seminars in Respiratory Critical Care Medicine 2023 August [Link] Abhinav Agrawal, Udit Chaddha, Samira Shojaee, Fabien Maldonado Abstract Malignant pleural diseases involves both primary pleural malignancies (e.g., mesothelioma) as well as metastatic disease involving the pleura. The management of primary pleural malignancies remains a challenge, given their limited response to conventional treatments such as surgery,…

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High Expression of SMO and GLI1 Genes with Poor Prognosis in Malignant Mesothelioma

Biomed Research International 2023 April 24 [Link] Guan-Ying Ma, Shuai Shi, Yin-Zhou Sang, Ping Wang, Zhi-Gang Zhang Abstract Background: To investigate the value of SMO and GLI1 genes in the hedgehog pathway in malignant mesothelioma specimens. Further study on the expression and prognosis of SMO and GLI1 in malignant mesothelioma tissues and the relationship between…

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Comprehensive epithelial biomarker analysis of malignant mesothelioma: EpCAM positivity is a potential diagnostic pitfall

Cancer Cytopathology 2023 April 17 [Link] Yili Zhu, Simone Moore, Aihui Wang, Elizabeth George, Grace M Allard, Diane M Libert, Alarice C Lowe Abstract Background: Epithelial cell adhesion molecule (EpCAM) is frequently used to distinguish carcinoma from background mesothelial cells during cytologic examination of body cavity fluids. Previously, the authors identified one malignant mesothelioma case…

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Establishment of an experimental model of canine malignant mesothelioma organoid culture using a three-dimensional culture method

Biomedicine and Pharmacotherapy 2023 June [Link] Yomogi Sato, Mohamed Elbadawy, Kazuhiko Suzuki, Ryouichi Tsunedomi, Hiroaki Nagano, Yusuke Ishihara, Haru Yamamoto, Daigo Azakami, Tsuyoshi Uchide, Rina Nabeta, Ryuji Fukushima, Amira Abugomaa, Masahiro Kaneda, Hideyuki Yamawaki 10, Yuta Shinohara, Tatsuya Usui, Kazuaki Sasaki Abstract Canine malignant mesothelioma (cMM) is a rare and drug-resistant malignant tumor. Due to…

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The cytological features of effusions with mesothelioma in situ: A report of 9 cases

Diagnostic Cytopathology 2023 March 21 [Link] Claire W Michael, Carlos C W M Bedrossian, Navid Sadri, Sonja Klebe Abstract Introduction: The diagnosis of mesothelioma in situ (MIS) is now accepted by the WHO as a pre-invasive neoplastic mesothelial proliferation and considered a diagnosis based on histologic evaluation only. Although the definition of MIS includes recurrent…

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A rare case of primary gastric Burkitt’s lymphoma associated with malignant pleural mesothelioma

Annali Italiani di Chirurgia 2023 March 6 [Link] Erasmo Spaziani, Annalisa Romina Di Filippo, Giampaolo Valle, Martina Spaziani, Piero Francioni, Gianluca Caruso, Giovanni Traumueller Tamagnini, Edoardo Mosciatti, Marcello Picchio, Alessandro De Cesare Abstract Background: Primary gastric Burkitt lymphoma (PG BL) and malignant pleural mesothelioma (MPM) are rare and aggressive tumors with poor prognosis. HIV and…

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