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Curated Journal Articles on Mesothelioma

Category Archives: Symptoms & Symptom Management

Malignant cells from pleural fluids in malignant mesothelioma patients reveal novel mutations

Lung Cancer, Amsterdam, Netherlands Epub 2018 March 9 [Link] Sneddon S, Dick I, Lee YCG, Musk AWB, Patch AM, Pearson JV, Waddell N, Allcock RJN, Holt RA, Robinson BWS, Creaney J Abstract OBJECTIVES: Malignant mesothelioma (MM) is an asbestos related tumour affecting cells of serosal cavities. More than 70% of MM patients develop pleural effusions […]

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The current aetiology of malignant pleural effusion in the Western Cape Province, South Africa

South African Medical Journal 2018 March 28 [Link] Koegelenberg CFN1, Bennji SM, Boer E, Schubert PT, Shaw JA, Allwood BW, Irusen EM Abstract BACKGROUND: Malignant pleural effusion (MPE) represents a very common cause of pleural exudates, and is one of the most challenging pleural disorders to manage. This could be attributed to the paucity of […]

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Malignant pleural mesothelioma: diagnostic value of medical thoracoscopy and long-term prognostic analysis

Pulmonary Medicine 2018 April 3 [Link] Xu LL, Yang Y, Wang Z, Wang XJ, Tong ZH, Shi HZ Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is marked by its difficult diagnosis and poor prognosis. Medical thoracoscopy (MT) is an effective and safe procedure for the diagnosis of exudative pleural effusions and many factors associated with poor […]

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Randomised controlled trial to compare the diagnostic yield of positron emission tomography CT (PET-CT) TARGETed pleural biopsy versus CT-guided pleural biopsy in suspected pleural malignancy (TARGET trial)

BMJ Open Respiratory Research 2018 February 19 [Link] de Fonseka D, Underwood W, Stadon L, Rahman N, Edey A, Rogers C, Maskell NA Abstract INTRODUCTION: Pleural malignancy, particularly malignant pleural mesothelioma (MPM) is increasing in incidence due to the long latency period from exposure to asbestos to development of the disease. MPM can be challenging […]

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Malignant Pleural Mesothelioma: Are There Imaging Characteristics Associated With Different Histologic Subtypes on Computed Tomography?

Journal of Computer Assisted Tomography 2018 April 2 [Epub ahead of print] [Link] Escalon JG, Harrington KA, Plodkowski AJ, Zheng J, Capanu M, Zauderer MG, Rusch VW, Ginsberg MS Abstract OBJECTIVES: Determine imaging characteristics specific to epithelioid (eMPM), sarcomatoid (sMPM), and biphasic (bMPM) subtypes of malignant pleural mesothelioma (MPM) on computed tomography. METHODS: Preoperative computed […]

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Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications

Journal of the National Cancer Institute 2018 March 21 [Epub ahead of print] [Link] Barash U Abstract BACKGROUND: Mammalian cells express a single functional heparanase, an endoglycosidase that cleaves heparan sulfate and thereby promotes tumor metastasis, angiogenesis, and inflammation. Malignant mesothelioma is highly aggressive and has a poor prognosis because of the lack of markers […]

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Survivin is a negative prognostic factor in malignant pleural effusion

European Journal of Clinical Investigation 2018 January 23 [Epub ahead of print] [Link] Arellano-Orden E et. al. Abstract SURVIVIN: is a well-known member of the inhibitor of apoptosis family, and has been related with increased tumour aggressivity, both in tissue and in pleural fluid. OBJECTIVES: In patients with malignant pleural effusion, we sought to investigate […]

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Diagnostic rentability of close pleural biopsy: Tru-cut vs. Cope

Revista Medica del Instituto Mexicano del Seguro Social 2018 January Valdez-López HG, Cano-Rodríguez AI, Montemayor-Chapa M, Castillo-Sánchez JF Abstract BACKGROUND: The prevalence of pleural effusion in Mexico is over 400 per 100 000 inhabitants. The etiology is infectious in 45.7% and neoplastic in 32.6%. Closed pleural biopsy sensibility is 48-70% in cancer and 50-59% in […]

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Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease

Journal of Investigative Medicine 2018 January 6 [Epub ahead of print] [Link] Solbes E, Harper RW Abstract Asbestos comprises a group of fibrous minerals that are naturally occurring in the environment. Because of its natural properties, asbestos gained popularity for commercial applications in the late 19th century and was used throughout the majority of the […]

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A Case of the Resected Lymphohistiocytoid Mesothelioma: BAP1 Is a Key of Accurate Diagnosis

Anticancer Research 2017 December [Link] Matsubara T Abstract BACKGROUND: Malignant mesothelioma (MM) is a well-known malignant tumor that occurs in the pleura and is histopathologically classified into three subtypes. Lymphohistiocytoid mesothelioma (LHM) is considered a variant of epithelioid MM, and few cases have been reported. First case of LHM was reported by Henderson et al. […]

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