Phase I Trial of Cediranib in combination with cisplatin and pemetrexed in chemo naive patients with unresectable malignant pleural mesothelioma (SWOG S0905)

Journal of Thoracic Oncology 2017 June 6 [Epub ahead of print] [Link] Tsao AS, Moon J, Wistuba II, Vogelzang NJ, Kalemkerian GP, Redman MW, Gandara DR, Kelly K Abstract BACKGROUND: In malignant pleural mesothelioma (MPM), targeting angiogenesis, with cediranib, a vascular endothelial growth factor receptor (VEGFR) and platelet derived growth factor receptor (PDGFR) inhibitor, may…

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Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers.

Journal of Clinical Oncology 2017 April [Epub ahead of print] [Link] Beddowes E, Spicer J, Chan PY, Khadeir R, Corbacho JG, Repana D, Steele JP, Schmid P, Szyszko T, Cook G, Diaz M, Feng X, Johnston A, Thomson J, Sheaff M, Wu BW, Bomalaski J, Pacey S, Szlosarek PW Abstract Purpose Pegylated arginine deiminase (ADI-PEG…

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A phase II trial of dovitinib in previously-treated advanced pleural mesothelioma: The Ontario Clinical Oncology Group

Lung Cancer (Netherlands) 2017 February [Epub 2016 December 15] [Link] Laurie SA, Hao D, Leighl NB, Goffin J, Khomani A, Gupta A, Addison CL, Bane A, Seely J, Filion ML, Pond GR, Levine MN Abstract OBJECTIVES: Following failure of a platinum-antifolate combination regimen, there is no standard therapy for advanced malignant pleural mesothelioma (MPM). The…

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Therapy response in malignant pleural mesothelioma-role of MRI using RECIST, modified RECIST and volumetric approaches in comparison with CT

European Radiology. 2008 Mar 28 [Epub ahead of print] [Link] Plathow C, Klopp M, Thieke C, Herth F, Thomas A, Schmaehl A, Zuna I, Kauczor HU. Department of Nuclearmedicine, University of Freiburg, Hugstetter 55, 79106, Freiburg, Germany, christian.plathow@uniklinik-freiburg.de. Abstract To evaluate and compare early therapy response according to RECIST (response evaluation criteria in solid tumours)…

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Assessment of tumor response in malignant pleural mesothelioma

Cancer Treatment Reviews. 2007 Oct;33(6):533-41. Epub 2007 Aug 30. [Link] Ceresoli GL, Chiti A, Zucali PA, Cappuzzo F, De Vincenzo F, Cavina R, Rodari M, Poretti D, Lutman FR, Santoro A. Department of Medical Oncology and Hematology, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy. giovanni_luca.ceresoli@humanitas.it Abstract Most patients with malignant pleural mesothelioma (MPM) are candidates…

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Malignant pleural mesothelioma: Two cases in first degree relatives

Lung Cancer. 2007 Mar 30; [Epub ahead of print] [Link] Anna Wilkinsa, Sanjay Popata, Sarah Hughesa and Mary O’Briena aDepartment of Medical Oncology, Royal Marsden Hospital, Sutton, SURREY SM2 5PT, United Kingdom Received 18 July 2006; revised 1 February 2007; accepted 8 February 2007. Available online 2 April 2007. Abstract We report two cases of…

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Malignant pleural mesothelioma: staging systems

Lung Cancer. 2005 Jul;49 Suppl 1:S45-8. Epub 2005 Mar 29. [Link] Schil PV. Department of Thoracic and Vascular Surgery, University Hospital of Antwerp, Wilrijkstraat 10, B-2650 Edegem, Antwerp, Belgium. paul.van.schil@uza.be Abstract Malignant pleural mesothelioma has a very specific growth pattern invading the pleural surfaces and neighboring structures. For this reason precise estimation of tumor volume…

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