The utility of serum N-ERC/mesothelin as a biomarker of ovarian carcinoma

Oncology Letters.. 2012 Oct;4(4):637-641. Epub 2012 Jul 11. [Link] Saeki H, Hashizume A, Izumi H, Suzuki F, Ishi K, Nojima M, Maeda M, Hino O. Departments of Diagnostic Pathology. Abstract Ovarian carcinoma has been difficult to diagnose at an early stage. Recently, it has been recognized that the measurement of blood N-ERC/mesothelin levels aids early…

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miR-1254 and miR-574-5p: Serum-Based microRNA Biomarkers for Early-Stage Non-small Cell Lung Cancer

Journal of Thoracic Oncology. 2011 Jan 20. [Epub ahead of print] [Link] Foss KM, Sima C, Ugolini D, Neri M, Allen KE, Weiss GJ. *Translational Genomics Research Institute, Phoenix, Arizona; †Department of Oncology, Biology and Genetics, University of Genoa, Genoa; ‡Unit of Epidemiology, Biostatistics and Clinical Trials, National Cancer Research Institute, Genoa; §Rehabilitative Pneumology, IRCCS…

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Exposure to asbestos: correlation between blood levels of mesothelin and frequency of micronuclei in peripheral blood lymphocytes

Mutation Research. 2011 Jan 13. [Epub ahead of print] [Link] Marini V, Michelazzi L, Cioé A, Fucile C, Spigno F, Robbiano L. Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV, 2, I-16132 Genoa, Italy. Abstract Inhalation of asbestos, a mineral extensively used in a variety of applications,…

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Expression of GATA-6 transcription factor in pleural malignant mesothelioma and metastatic pulmonary adenocarcinoma

Journal of Clinical Pathology. 2009 Apr;62(4):339-44. Epub 2008 Dec 5. [Link] Expression of GATA-6 transcription factor in pleural malignant mesothelioma and metastatic pulmonary adenocarcinoma. Lindholm PM, Soini Y, Myllärniemi M, Knuutila S, Heikinheimo M, Kinnula VL, Salmenkivi K. Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Finland. Abstract Background: Malignant mesothelioma (MM)…

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Biomarkers for malignant pleural mesothelioma: current status

Molecular Diagnosis & Therapy. 2008;12(6):375-90. doi: 10.2165/1250444-200812060-00004. [Link] Greillier L, Baas P, Welch JJ, Hasan B, Passioukov A. European Organisation for Research and Treatment of Cancer (EORTC), Headquarters, Brussels, Belgium. laurent.greillier@mail.ap-hm.fr Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis, whose main etiology is exposure to asbestos fibers. The incidence of MPM…

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Malignant pleural mesothelioma: biology and diagnosis

Revue des Maladies Respiratoires. 2008 Oct;25(8 Pt 2):3S183-90. [Link] Scherpereel A, Grigoriu BD, Astoul P. Service de Pneumologie et Oncologie Thoracique, Hôpital Calmette, CHRU de Lille, Lille, France. a-scherpereel@chru-lille.fr Abstract Malignant pleural mesothelioma (MPM) is a serious issue worldwide because of its increasing incidence and poor prognosis despite real recent improvements in the disease management.…

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Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma

Oncology Reports. 2008 Dec;20(6):1375-80. [Link] Inami K, Kajino K, Abe M, Hagiwara Y, Maeda M, Suyama M, Watanabe S, Hino O. Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113-8421, Japan. Abstract ERC/mesothelin gene (MSLN) encodes a precursor protein, which is cleaved by proteases to generate N-ERC/mesothelin and C-ERC/mesothelin. N-ERC/mesothelin is a…

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Diagnostic and prognostic value of soluble mesothelin-related proteins in patients with malignant pleural mesothelioma in comparison with benign asbestosis and lung cancer

Journal of Thoracic Oncology. 2008 Nov;3(11):1317-24. [Link] Schneider J, Hoffmann H, Dienemann H, Herth FJ, Meister M, Muley T. Institute and Policlinic for Occupational and Social Medicine, Justus-Liebig Universität, Giessen, Germany. Abstract Introduction and Methods: We investigated the diagnostic and prognostic value of soluble mesothelin-related proteins (SMRP) in sera from patients with newly diagnosed malignant…

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Alterations in manganese, copper, and zinc contents, and intracellular status of the metal-containing superoxide dismutase in human mesothelioma cells

Journal of Trace Elements in Medicine and Biology. 2008;22(3):248-55. Epub 2008 Jul 18. [Link] Hasegawa S, Koshikawa M, Takahashi I, Hachiya M, Furukawa T, Akashi M, Yoshida S, Saga T. Diagnostic Imaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. shase@nirs.go.jp Abstract Background and Aim: Molecular diagnostics and…

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Comparison of Osteopontin, Megakaryocyte Potentiating Factor, and Mesothelin Proteins as Markers in the Serum of Patients with Malignant Mesothelioma

Journal of Thoracic Oncology. 2008 Aug;3(8):851-7. [Link] Creaney J, Yeoman D, Demelker Y, Segal A, Musk AW, Skates SJ, Robinson BW. National Research Centre for Asbestos Related Diseases, Western Australian Institute of Medical Research, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Nedlands, Australia. creaneyj@cyllene.uwa.edu.au Abstract Introduction: There is increasing…

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