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Curated Journal Articles on Mesothelioma

Category Archives: microRNA

The analysis of novel microRNA mimic sequences in cancer cells reveals lack of specificity in stem-loop RT-qPCR-based microRNA detection

BMC Research Notes 2017 November [Link] Winata P, Williams M McGowan E, Nassif N, van Zandwijk N, Reid G Abstract OBJECTIVE: MicroRNAs are frequently downregulated in cancer, and restoring expression has tumour suppressive activity in tumour cells. Our recent phase I clinical trial investigated microRNA-based therapy in patients with malignant pleural mesothelioma. Treatment with TargomiRs, […]

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Dysregulated expression of the microRNA miR-137 and its target YB-1 contribute to the invasive characteristics of malignant pleural mesothelioma

Journal of Thoracic Oncology 2017 November 4 [Epub ahead of print] [Link] Johnson TG, et. al., Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterised by frequent chromosomal deletions of tumour suppressors, including microRNAs. MiR-137 plays a tumour suppressor role in other cancers, […]

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A link between the fibroblast growth factor axis and the miR-16 family reveals potential new treatment combinations in Mesothelioma

Molecular Oncology 2017 November 1 [Epub ahead of print] [Link] Schelch K, Kirschner MB, Williams M, Cheng YY, van Zandwijk N, Grusch M, Reid G Abstract Malignant pleural mesothelioma (MPM) is an aggressive malignancy with very limited therapeutic options. Fibroblast growth factor (FGF) signals play important roles in mesothelioma cell growth. Several FGFs and FGF […]

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Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

Oncotarget 2017 August [Link] Birnie KA, PrĂȘle CM, Thompson PJ, Badrian B, Mutsaers S Abstract Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced […]

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ANNALS EXPRESS: Biomarkers in mesothelioma

Annals of Clinical Biochemistry 2017 January [Epub ahead of print] [Link] Arnold DT, Maskell N Abstract Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to diagnose and monitor. Numerous studies have attempted to identify a blood- or pleural fluid-based biomarker that could be used in the diagnostic pathway. More recently […]

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Downregulation of miR-99a/let-7c/miR-125b miRNA cluster predicts clinical outcome in patients with unresected malignant pleural mesothelioma

Oncotarget 2017 August [Link] Truini A, et.al. Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor with a dismal overall survival (OS) and to date no molecular markers are available to guide patient management. This study aimed to identify a prognostic miRNA signature in MPM patients who did not undergo tumor resection. Whole miRNA profiling […]

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MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma

Molecular Therapy. Nucleic Acids 2017 September [Epub 2017 July 8] [Link] Moody HL, Lind MJ, Maher SG Asbstract Malignant pleural mesothelioma (MPM) is associated with an extremely poor prognosis, and most patients initially are or rapidly become unresponsive to platinum-based chemotherapy. MicroRNA-31 (miR-31) is encoded on a genomic fragile site, 9p21.3, which is reportedly lost […]

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Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

The Lancet. Oncology 2017 September [Epub ahead of print] [Link] van Zandwijk N, Pavlakis N, Kao SC, Linton A, Boyer MJ, Clarke S, Huynh Y, Chrzanowska A, Fulham MJ, Bailey DL, Cooper WA, Kritharides L, Ridley L, Pattison ST, MacDiarmid J, Brahmbhatt H, Reid G Abstract BACKGROUND: TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with […]

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Clinical staging of malignant pleural mesothelioma: current perspectives

Lung Cancer 2017 August [Link] Bonomi M, De Filippis C, Lopci E, Gianoncelli L, Rizzardi G, Cerchiaro E, Bortolotti L, Zanello A, Ceresoli G Abstract Malignant pleural mesothelioma (MPM) is a disease with limited therapeutic options, the management of which is still controversial. Diagnosis is usually made by thoracoscopy, which allows multiple biopsies with histological […]

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Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma

Biomedicine & Pharmacotherapy 2017 August [Epub ahead of print] [Link] Sayeed MA, Bracci M, Lucarini G, Lazzarini R, Di Primio R, Santarelli L Abstract Malignant mesothelioma (MM) is a very aggressive, lethal cancer, and its incidence is increasing worldwide. Development of multi-drug resistance, therapy related side-effects, and disease recurrence after therapy are the major problems […]

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