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Curated Journal Articles on Mesothelioma

Category Archives: microRNA

New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma

Frontiers in Oncology 2018 April [Link] Rossini M, Rizzo P, Bononi I, Clementz A, Ferrari R, Martini F, Tognon MG Abstract Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world. It develops in about one to two persons […]

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Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma

Journal of Cellular and Molecular Medicine 2018 March 24 [Epub ahead of print] [Link] Hsu PC, et. al. Abstract Although tumour PD-L1 (CD274) expression had been used as a predictive biomarker in checkpoint immunotherapy targeting the PD1/PD-L1 axis in various cancers, the regulation of PD-L1 (CD274) expression is unclear. Yes-associated protein (YAP), an important oncogenic […]

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Secreted and Tissue miRNAs as Diagnosis Biomarkers of Malignant Pleural Mesothelioma

International Journal of Molecular Sciences 2018 February [Link] Martínez-Rivera V, Negrete-García MC, Ávila-Moreno F, Ortiz-Quintero B Abstract Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates in the pleura, is diagnosed in advanced stages and has a poor prognosis. Accurate diagnosis of MPM is often difficult and complex, and the gold standard […]

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The analysis of novel microRNA mimic sequences in cancer cells reveals lack of specificity in stem-loop RT-qPCR-based microRNA detection

BMC Research Notes 2017 November [Link] Winata P, Williams M McGowan E, Nassif N, van Zandwijk N, Reid G Abstract OBJECTIVE: MicroRNAs are frequently downregulated in cancer, and restoring expression has tumour suppressive activity in tumour cells. Our recent phase I clinical trial investigated microRNA-based therapy in patients with malignant pleural mesothelioma. Treatment with TargomiRs, […]

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Dysregulated expression of the microRNA miR-137 and its target YB-1 contribute to the invasive characteristics of malignant pleural mesothelioma

Journal of Thoracic Oncology 2017 November 4 [Epub ahead of print] [Link] Johnson TG, et. al., Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterised by frequent chromosomal deletions of tumour suppressors, including microRNAs. MiR-137 plays a tumour suppressor role in other cancers, […]

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A link between the fibroblast growth factor axis and the miR-16 family reveals potential new treatment combinations in Mesothelioma

Molecular Oncology 2017 November 1 [Epub ahead of print] [Link] Schelch K, Kirschner MB, Williams M, Cheng YY, van Zandwijk N, Grusch M, Reid G Abstract Malignant pleural mesothelioma (MPM) is an aggressive malignancy with very limited therapeutic options. Fibroblast growth factor (FGF) signals play important roles in mesothelioma cell growth. Several FGFs and FGF […]

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Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

Oncotarget 2017 August [Link] Birnie KA, Prêle CM, Thompson PJ, Badrian B, Mutsaers S Abstract Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced […]

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ANNALS EXPRESS: Biomarkers in mesothelioma

Annals of Clinical Biochemistry 2017 January [Epub ahead of print] [Link] Arnold DT, Maskell N Abstract Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to diagnose and monitor. Numerous studies have attempted to identify a blood- or pleural fluid-based biomarker that could be used in the diagnostic pathway. More recently […]

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Downregulation of miR-99a/let-7c/miR-125b miRNA cluster predicts clinical outcome in patients with unresected malignant pleural mesothelioma

Oncotarget 2017 August [Link] Truini A, et.al. Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor with a dismal overall survival (OS) and to date no molecular markers are available to guide patient management. This study aimed to identify a prognostic miRNA signature in MPM patients who did not undergo tumor resection. Whole miRNA profiling […]

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MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma

Molecular Therapy. Nucleic Acids 2017 September [Epub 2017 July 8] [Link] Moody HL, Lind MJ, Maher SG Asbstract Malignant pleural mesothelioma (MPM) is associated with an extremely poor prognosis, and most patients initially are or rapidly become unresponsive to platinum-based chemotherapy. MicroRNA-31 (miR-31) is encoded on a genomic fragile site, 9p21.3, which is reportedly lost […]

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