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Curated Journal Articles on Mesothelioma

Category Archives: microRNA

MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma

Molecular Therapy. Nucleic Acids 2017 September [Epub 2017 July 8] [Link] Moody HL, Lind MJ, Maher SG Asbstract Malignant pleural mesothelioma (MPM) is associated with an extremely poor prognosis, and most patients initially are or rapidly become unresponsive to platinum-based chemotherapy. MicroRNA-31 (miR-31) is encoded on a genomic fragile site, 9p21.3, which is reportedly lost […]

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Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

The Lancet. Oncology 2017 September [Epub ahead of print] [Link] van Zandwijk N, Pavlakis N, Kao SC, Linton A, Boyer MJ, Clarke S, Huynh Y, Chrzanowska A, Fulham MJ, Bailey DL, Cooper WA, Kritharides L, Ridley L, Pattison ST, MacDiarmid J, Brahmbhatt H, Reid G Abstract BACKGROUND: TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with […]

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Clinical staging of malignant pleural mesothelioma: current perspectives

Lung Cancer 2017 August [Link] Bonomi M, De Filippis C, Lopci E, Gianoncelli L, Rizzardi G, Cerchiaro E, Bortolotti L, Zanello A, Ceresoli G Abstract Malignant pleural mesothelioma (MPM) is a disease with limited therapeutic options, the management of which is still controversial. Diagnosis is usually made by thoracoscopy, which allows multiple biopsies with histological […]

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Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma

Biomedicine & Pharmacotherapy 2017 August [Epub ahead of print] [Link] Sayeed MA, Bracci M, Lucarini G, Lazzarini R, Di Primio R, Santarelli L Abstract Malignant mesothelioma (MM) is a very aggressive, lethal cancer, and its incidence is increasing worldwide. Development of multi-drug resistance, therapy related side-effects, and disease recurrence after therapy are the major problems […]

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MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study

Disease Markers 2017 [Epub July 3] [Link] Mozzoni P, Ampollini L, Goldoni M, Alinovi R, Tiseo M, Gnetti L, Carbognani P, Rusca M, Mutti A, Percesepe A, Corradi Abstract BACKGROUND: The identification of diagnostic/prognostic biomarkers for asbestos-related diseases is relevant for early diagnosis and patient survival and may contribute to understanding the molecular mechanisms underlying […]

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Targeting eukaryotic protein translation in mesothelioma

Translational Lung Cancer Research 2017 June [Link] Kratzke RA Abstract The default mechanism for protein translation in eukaryotes involves activation of the eIF4 complex at the 5′ end of mRNA. This activity is upregulated in cancers, resulting in the expression of a variety of proteins necessary for the development and maintenance of the neoplastic state. […]

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Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers

Discovery Medicine 2017 May [Link Rimkus T, Sirkisoon S, Harrison A, Lo HW Abstract Tumor suppressor candidate 2 (TUSC2, also known as FUS1) was identified in 2000 as a candidate tumor suppressor gene located in a region on chromosome 3p21.3 that is homozygously deleted in some lung and breast cancers. The deletion is rare in […]

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Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma

Journal of Thoracic Oncology 2016 July [Epub ahead of print] [Link] Kao SC, Cheng YY, Williams M, Kirschner MB, Madore J, Lum T, Sarun KH, Linton A, McCaughan B, Klebe S, van Zandwijk N, Scolyer RA, Boyer MJ, Cooper WA, Reid G Abstract INTRODUCTION: The upregulation of PD-L1 is found in many cancers and contributes […]

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Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism

Scientific Reports 2017 June [

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Targeting YAP in malignant pleural mesothelioma

Journal of Cellular and Molecular Medicine 2017 Ma 4 [Epub ahead of print] [Link] Zhang WQ, Dai YY, Hsu PC, Wang H, Cheng L, Yang YL, Wang YC, Xu ZD, Liu S, Chan G, Hu B, Li H, Jablons DM, You L Abstract Malignant mesothelioma is an aggressive cancer that is resistant to current therapy. […]

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