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Curated Journal Articles on Mesothelioma

Category Archives: Immunohistochemistry or IHC

Often used to diagnose cancer, Immunohistochemistry or IHC is a process by which antibodies are detected in tissue samples by use of a specific antigen or antigens. IHC is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue (also see “Serum Marker/Blood Test“).

Large primary pleural synovial sarcoma with severe dyspnea: a case report

Surgical Case Reports [Epub 2017 February 15] [Link] Yamaki M, Yonehara S, Noriyuki T Abstract BACKGROUND: Synovial sarcoma is a malignant neoplasm of soft tissues. It occurs mainly in the extremities and is closely related to tendons, tendon sheaths, and bursal structures. Primary synovial sarcoma of the pleura and lungs is extremely rare. CASE PRESENTATION: […]

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MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma

Modern Pathology 2017 January 27 [Epub ahead of print] [Link] Amatya VJ, Kushitani K, Mawas AS, Miyata Y, Okada M, Kishimoto T, Inai K, Takeshima Y Abstract Sarcomatoid mesothelioma, a histological subtype of malignant pleural mesothelioma, is a very aggressive tumor with a poor prognosis. Histological diagnosis of sarcomatoid mesothelioma largely depends on the histomorphological […]

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Small bowel metastasis from pancreatic cancer in a long-term survival patient with synchronous advanced malignant pleural mesothelioma: A case report and literature review

Oncology Letters 2016 December [Epub 2016 October] [Link] Fasano M, Corte CM, Vicidomini G, Scotti V, Rambaldi PF, Fiorelli A, Accardo M, De Vita F, Santini M, Ciardiello F, Morgillo F Abstract Diffuse malignant pleural mesothelioma (MPM) is an aggressive tumor that originates from the surface of the pleura. Approximately 70% of cases are associated […]

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Pleural fluid cytology samples in cases of suspected lung cancer: An experience from a tertiary care centre

Diagnostic Cytopathology 2017 January 23 [Epub ahead of print] [Link] Kaur G, Nijhawan R, Gupta N, Singh N, Rajwanshi A Abstract OBJECTIVE: Pleural effusion is present in some patients with lung carcinoma. This study was undertaken to evaluate the role of pleural fluid cytology in suspected cases of lung carcinoma. METHODS: In this prospective study, […]

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Usefulness of p16/CDKN2A fluorescence in situ hybridization and BAP1 immunohistochemistry for the diagnosis of biphasic mesothelioma

Annals of diagnostic pathology 2017 Feb [Epub 2016 October 22] [Link] Wu D, Hiroshima K, Yusa T, Ozaki D, Koh E, Sekine Y, Matsumoto S, Nabeshima K, Sato A, Tsujimura T, Yamakawa H, Tada Y, Shimada H, Tagawa M Abstract Malignant mesothelioma is a highly aggressive neoplasm, and the histologic subtype is one of the […]

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Asbestos fibres detected by scanning electron microscopy in the gallbladder of patients with malignant pleural mesothelioma (MPM)

Journal of Microscopy 2017 January 9 [Epub ahead of print] [Link] Grosso F, Croce A, Trincheri NF, Mariani N, Libener R, Degiovanni D, Rinaudo C Abstract Gallbladders from patients affected by both malignant pleural mesothelioma (MPM) and important gallbladder disorders were analyzed to verify the presence of asbestos fibres. Histological thin sections were analyzed by […]

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Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial

JAMA Oncology 2017 January [Link] Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S, Shamash J, Phillips MM, Luong P, Payne S, Hillman P, Ellis S, Szyszko T, Dancey G, Butcher L, Beck S, Avril NE, Thomson J, Johnston A, Tomsa M, Lawrence C, Schmid P, Crook T, […]

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The importance of EZH2 and MOC-31 expression in the differential diagnosis of benign and malignant effusions

Diagnostic Cytopathology 2016 December 26 [Epub ahead of print] [Link] Sadullahoglu C, Nart D, Veral A Abstract BACKGROUND: All malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due […]

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Signal Transducer and Activator of Transcription 1 (STAT1) Knock-down Induces Apoptosis in Malignant Pleural Mesothelioma

Pathology Oncology Research 2016 December [Epub ahead of print] [Link] Arzt L, Halbwedl I, Gogg-Kamerer M3, Popper HH Abstract Malignant pleural mesothelioma (MPM) is the most common primary tumor of the pleura. Its incidence is still increasing in Europe and the prognosis remains poor. We investigated the oncogenic function of signal transducer and activator of […]

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Trametinib plus 4-methylumbelliferone exhibits antitumor effects by ERK blockade and CD44 downregulation and affects PD1 and PD-L1 in malignant pleural mesothelioma

Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer 2016 November 17 [Epub ahead of print] [Link] Cho H, Matsumoto S, Fujita Y, Kuroda A, Menju T, Sonobe M, Kondo N, Torii I, Nakano T, Lara PN, Gandara DR, Date H, Hasegawa S Abstract INTRODUCTION: Malignant pleural mesothelioma […]

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