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Curated Journal Articles on Mesothelioma

Category Archives: Immunohistochemistry or IHC

Often used to diagnose cancer, Immunohistochemistry or IHC is a process by which antibodies are detected in tissue samples by use of a specific antigen or antigens. IHC is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue (also see “Serum Marker/Blood Test“).

The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: Evidence-Based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.

Human Pathology 2017 August 4 [Epub ahead of print] [Link] Marchevsky AM, et. al. Abstract Immunohistochemistry is used to distinguish sarcomatoid malignant mesotheliomas (SMM) from spindle cell and pleomorphic carcinomas (SPC) but there are no guidelines on how to interpret cases that show overlapping or equivocal immunohistochemical findings. A systematic literature review of the immunophenotype […]

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Magnetic nanoparticles-based therapy for malignant mesothelioma

Romanian Journal of Morphology and Embryology [2017] [Link] Mîndrilă I, Buteică SA, Mihaiescu DE, Burada F, Mîndrilă B, Predoi MC, Pirici I, Fudulu A, Croitoru O Abstract This work was aimed to analyze the versatility of the chick embryo chorioallantoic membrane (CAM) as in vivo model for the study of the malignant pleural mesothelioma (MPM) […]

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Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.

Archives of pathology and laboratory medicine 2017 July [Epub ahead of print] [Link] Husain AN et.al. Abstract CONTEXT: – Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: – To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: – Pathologists involved in the International Mesothelioma Interest […]

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Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma

Journal of Thoracic Oncology 2016 July [Epub ahead of print] [Link] Kao SC, Cheng YY, Williams M, Kirschner MB, Madore J, Lum T, Sarun KH, Linton A, McCaughan B, Klebe S, van Zandwijk N, Scolyer RA, Boyer MJ, Cooper WA, Reid G Abstract INTRODUCTION: The upregulation of PD-L1 is found in many cancers and contributes […]

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Immunohistochemical evaluation of two antibodies against PD-L1 and http://www.mesothelioma-line.com/wp-login.php?action=logout&_wpnonce=d22f9156abprognostic significance of PD-L1 expression in epithelioid peritoneal malignant mesothelioma: A RENAPE study

European Journal of Surgical Oncology 2017 May [Epub ahead of print] [Link] Valmary-Degano S, Colpart P, Villeneuve L, Monnien F, M’Hamdi L, Lang Averous G, Capovilla M, Bibeau F, Laverriere MH, Verriele-Beurrier V, Ben Rejeb H, Dartigues P, Hommell-Fontaine J, Gilly FN, Isaac S, Mery E; French RENAPE Network Abstract BACKGROUND: Epithelioid peritoneal malignant mesothelioma […]

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GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung

American Journal of Surgical Pathology 2017 June [Epub ahead of print] [Link] Berg KB, Churg A Abstract The separation of sarcomatoid and desmoplastic malignant mesotheliomas from sarcomatoid carcinomas of the lung metastatic to the pleura may be difficult, since both types of tumor can be morphologically similar and are frequently positive only for pan-keratin. GATA […]

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Targeting CXCR4 with [68Ga]Pentixafor: a suitable theranostic approach in pleural mesothelioma?

Oncotarget 2017 May [Epub ahead of print] [Link] Lapa C, Kircher S, Schirbel A, Rosenwald A, Kropf S, Pelzer T, Walles T, Buck AK, Weber WA, Wester HJ, Herrmann K, Lückerath K Abstract C-X-C motif chemokine receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several types of human cancer. This […]

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DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma

International Journal of Oncology 2017 May [Epub ahead of print] [Link] Wang H, Dai YY, Zhang WQ, Hsu PC, Yang YL, Wang YC, Chan G, Au A, Xu ZD, Jiang SJ, Wang W, Jablons DM, You L Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this […]

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A Subset of Malignant Mesotheliomas in Young Adults are Associated With Recurrent EWSR1/FUS-ATF1 Fusions

The American Journal of Surgical Pathology 2017 May 12 [Epub ahead of print] [Link] Desmeules P, Joubert P, Zhang L, Al-Ahmadie HA, Fletcher CD, Vakiani E, Delair DF, Rekhtman N, Ladanyi M, Travis WD, Antonescu CR Abstract Malignant mesothelioma (MM) is a rare, aggressive tumor often associated with asbestos exposure and characterized by complex genetic […]

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Multiple malignant epithelioid mesotheliomas of the liver and greater omentum: a case report and review of the literature

Surgical Case Reports [Epub May 10] [Link] Minami K, Okumura H, Hiwatashi K, Matsukita S, Setoyama T, Minamimagari K, Tsuruta Y, Kanetsuki I, Ogura Y, Maenohara S, Natsugoe S Abstract BACKGROUND: Malignant mesothelioma commonly arises from the pleura, but can also arise from the peritoneum, pericardium, and tunica vaginalis testis. However, malignant mesothelioma of the […]

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