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Curated Journal Articles on Mesothelioma

Category Archives: Diagnosis & Differentiation

SMARCB1/INI1/BAF47- deficient pleural malignant mesothelioma with rhabdoid features

Pathology International 2018 January 5 [Epub ahead of print] [Link] Kimura N, Hasegawa M, Hiroshima K Abstract Malignant mesothelioma (MM) with rhabdoid features is an MM variant. Fifteen cases have been reported previously, all of which were combined with other types of MM. Herein, we report an autopsy case of pleural MM with monomorphic rhabdoid […]

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Omentin-A Novel Adipokine in Respiratory Diseases

International Journal of Molecular Sciences 2017 December [Link] Zhou Y, Zhang B, Hao C, Huang X, Li X, Huang Y, Luo Z Abstract Adipokines, secreted by the adipose tissue, are extensively involved in the regulation and maintenance of various physiological and pathological processes, including insulin sensitivity, energy expenditure, glucose and lipid metabolism, inflammatory activity, neuroendocrine […]

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Malign pleural mesothelioma – so far an undefeated tumor

Vnitrni lekarstvi 2018 [Link] Kolek V. Abstract Malign pleural mesothelioma is the most frequent primary tumor of the pleura of high aggressiveness. Its most frequent cause is contact with asbestos and, although working with asbestos is already prohibited in developed countries, its incidence is on the increase so far. Diagnostics primarily considers anamnesis, clinical symptoms […]

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A genetic variant of NLRP1 gene is associated with asbestos body burden in patients with malignant pleural mesothelioma

Journal of Toxicology 2017 December [Epub ahead of print] [Link] Crovella S. et.al. Abstract The presence of asbestos bodies (ABs) in lung parenchyma is considered a histopathologic hallmark of past exposure to asbestos fibers, of which there was a population of longer fibers. The mechanisms underlying AB formation are complex, involving inflammatory responses and iron […]

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Exhaled breath to screen for malignant pleural mesothelioma: a validation study

The European Respiratory Journal 2017 December 21 [Link] Lamote K, Vynck M, Thas O, Van Cleemput J, Nackaerts K, van Meerbeeck JP Abstract Malignant pleural mesothelioma (MPM) is predominantly caused by asbestos exposure and has a poor prognosis. Breath contains volatile organic compounds (VOCs) and can be explored as an early detection tool. Previously, we […]

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Difficulty in positive diagnosis of ascites and in differential diagnosis of a pulmonary tumor

Roman Journal of Morphology and Embryology 2017 [Link] ForŢofoiu MC Abstract Ascites is the most frequent complication of cirrhosis and occurs only when the portal hypertension has already installed but ascites is caused by neoplasms, heart failure, tuberculosis, pancreatic illnesses, as well as other kind of affections. We describe the case of a 67-year-old patient, […]

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Endoscopic ultrasound-guided fine-needle aspiration from ascites and peritoneal nodules: A scoping review

Endoscopic Ultrasound 2017 November-December [Link] Sharma V, Rana SS, Ahmed SU, Guleria S, Sharma R, Gupta R Abstract The peritoneum is involved in many diseases such as primary malignancy (mesothelioma), infectious disease (tuberculosis), and disseminated malignancy (peritoneal carcinomatosis). The peritoneal disease may manifest as ascites and/or peritoneal masses or nodules. Endoscopic ultrasound (EUS), due to […]

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Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth

Frontiers in Immunology 2017 November [Link] Agostinis C et. al. Abstract C1q is the first recognition subcomponent of the complement classical pathway, which acts toward the clearance of pathogens and apoptotic cells. C1q is also known to modulate a range of functions of immune and non-immune cells, and has been shown to be involved in […]

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Breath analysis by gas chromatography-mass spectrometry and electronic nose to screen for pleural mesothelioma: a cross-sectional case-control study

Oncotarget 2017 September [Link] Lamote K, et. al Abstract RATIONALE: Malignant pleural mesothelioma (MPM) is mainly caused by previous exposure to asbestos fibers and has a poor prognosis. Due to a long latency period between exposure and diagnosis, MPM incidence is expected to peak between 2020-2025. Screening of asbestos-exposed individuals is believed to improve early […]

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Targeting CXCR4 with [68Ga]Pentixafor: a suitable theranostic approach in pleural mesothelioma?

Oncotarget 2017 November 14 [Link] Lapa C et. al. Abstract C-X-C motif chemokine receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several types of human cancer. This study investigated the feasibility of CXCR4-directed imaging with positron emission tomography/computed tomography (PET/CT) using [68Ga]Pentixafor in malignant pleural mesothelioma. Six patients with pleural […]

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