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Curated Journal Articles on Mesothelioma

Category Archives: Diagnosis & Differentiation

Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?

Oncotarget 2017 May [Link] Lagniau S, Lamote K, van Meerbeeck JP, Vermaelen KY Abstract Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing earlier detection will result in better patient […]

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Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma

Modern Pathology 2017 September [Epub ahead of print] [Link] Vivero M, Bueno R, Chirieac LR Abstract Pleural diffuse malignant mesothelioma typically presents during the seventh decade of life and has poor prognosis. Recent epidemiologic studies have shown differences between young and older mesothelioma patients, but the biology of pleural mesothelioma in young patients is poorly […]

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The epithelioid, BAP1-negative and p16-positive phenotype predicts prolonged survival in pleural mesothelioma

Histopathology 2017 September [Epub ahead of print] [Link] Chou A1, Toon CW1, Clarkson A1, Sheen A, Sioson L1 Gill AJ Abstract AIMS: Mesothelioma is a relatively uncommon but highly malignant neoplasm. Most patients die of disease within one year of diagnosis, but some have prolonged survival. Prospective identification of these longer-term survivors may help guide […]

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Clinical staging of malignant pleural mesothelioma: current perspectives

Lung Cancer 2017 August [Link] Bonomi M, De Filippis C, Lopci E, Gianoncelli L, Rizzardi G, Cerchiaro E, Bortolotti L, Zanello A, Ceresoli G Abstract Malignant pleural mesothelioma (MPM) is a disease with limited therapeutic options, the management of which is still controversial. Diagnosis is usually made by thoracoscopy, which allows multiple biopsies with histological […]

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Chest ultrasonography in health surveillance of asbestos related pleural disease

Lung Cancer 2017 September [Epub 2017 July 22] [Link] Scarlata S, Finamore P, Giannunzio G, Santangelo S, Antonelli Incalzi R Abstract High resolution computed tomography, (HRCT), is currently considered the diagnostic gold standard to diagnose early stage malignant pleural mesothelioma and other non-malignant pleural conditions, but it is expensive and exposes the patient to radiation […]

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Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma

Biomedicine & Pharmacotherapy 2017 August [Epub ahead of print] [Link] Sayeed MA, Bracci M, Lucarini G, Lazzarini R, Di Primio R, Santarelli L Abstract Malignant mesothelioma (MM) is a very aggressive, lethal cancer, and its incidence is increasing worldwide. Development of multi-drug resistance, therapy related side-effects, and disease recurrence after therapy are the major problems […]

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Diagnostic Imaging and workup of Malignant Pleural Mesothelioma

Acta Bio-Medica 2017 August [Link] Cardinale L, Ardissone F, Gned D, Sverzellati N, Piacibello E, Veltri A Abstract Malignant pleural mesothelioma is the most frequent primary neoplasm of the pleura and its incidence is still increasing.This tumor has a strong association with exposure to occupational or environmental asbestos, often after a long latent period of […]

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Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma

Human Pathology 2017 August 12 [Epub ahead of print] [Link] Inaguma S, Lasota J, Wang Z, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, OkoĊ„ K, Biernat W, Ikeda H, Schrump DS, Hassan R, Miettinen M Abstract Diffuse malignant mesothelioma of the pleura is a highly aggressive tumor typically associated with short survival. […]

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Evaluating the effect of immune cells on the outcome of patients with mesothelioma

British Journal of Cancer 2017 August 17 [Epub ahead of print] [Link] Chee SJ, Lopez M, Mellows T3, Gankande S, Moutasim KA, Harris S, Clarke J, Vijayanand P, Thomas GJ1, Ottensmeier CH Abstract BACKGROUND: We systematically assessed the prognostic and predictive value of infiltrating adaptive and innate immune cells in a large cohort of patients […]

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Malignant pleural mesothelioma segmentation for photodynamic therapy planning

Computerized Medical Imaging Society 2017 July [Epub ahead of print] [Link Brahim W, Mestiri M, Betrouni N, Hamrouni K Abstract Medical imaging modalities such as computed tomography (CT) combined with computer-aided diagnostic processing have already become important part of clinical routine specially for pleural diseases. The segmentation of the thoracic cavity represents an extremely important […]

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