New pathogenic germline variants identified in mesothelioma

Lung Cancer 2023 March 15 [Link] Laila Belcaid, Birgitte Bertelsen, Karin Wadt, Ida Tuxen, Iben Spanggaard, Martin Højgaard, Jens Benn Sørensen, Jesper Ravn, Ulrik Lassen, Finn Cilius Nielsen, Kristoffer Rohrberg, Christina Westmose Yde Abstract Background: Mesothelioma (MM) is associated with asbestos exposure, tumor heterogeneity and aggressive clinical behavior. Identification of germline pathogenic variants (PVs) in…

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Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma

Cancers 2023 February 28 [Link] Mhd Ouis Al Khatib, Giulia Pinton, Laura Moro, Chiara Porta Abstract Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer that is mainly associated with prior exposure to asbestos fibers. Despite being a rare cancer, its global rate is increasing and the prognosis remains extremely poor. Over the last two…

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The Evolving Role of Immune-Checkpoint Inhibitors in Malignant Pleural Mesothelioma

Journal of Clinical Medicine 2023 February 22 [Link] Maxime Borgeaud, Floryane Kim, Alex Friedlaender, Filippo Lococo, Alfredo Addeo, Fabrizio Minervini Abstract Malignant pleural mesothelioma (MPM) is a rare cancer usually caused by asbestos exposure and associated with a very poor prognosis. After more than a decade without new therapeutic options, immune checkpoint inhibitors (ICIs) demonstrated…

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MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma

Cell Death Discovery 2023 February 10 [Link] Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R R Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F Ochsenbein, Thomas M Marti, Gregor J Kocher, Ralph A Schmid, Patrick Dorn, Ren-Wang Peng Abstract Malignant pleural mesothelioma (MPM) is a lethal…

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miR-142-3p Suppresses Invasion and Adhesion of Mesothelioma Cells by Downregulating ITGAV

Pathobiology 2023 Febrary 1 [Link] Ihiro Endo, Vishwa Jeet Amatya, Kei Kushitani Tetsuya Nakagiri, Kohei Aoe, Yukio Takeshima Abstract Introduction: Malignant mesothelioma is an aggressive cancer associated with asbestos exposure. Currently, the efficacy of therapeutics is limited in malignant mesothelioma, and developing more effective therapies is the need of the hour. Non-coding RNAs (ncRNAs), including…

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A molecular phenotypic map of malignant pleural mesothelioma

GigaScience 2022 December 28 [Link] Alex Di Genova, Lise Mangiante, Alexandra Sexton-Oates, Catherine Voegele, Lynnette Fernandez-Cuesta, Nicolas Alcala, Matthieu Foll Abstract Background: Malignant pleural mesothelioma (MPM) is a rare understudied cancer associated with exposure to asbestos. So far, MPM patients have benefited marginally from the genomics medicine revolution due to the limited size or breadth…

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BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis-resistance

Cancer Science 2022 December 21 [Link] Yaguang Luo, Shinya Akatsuka, Yashiro Motooka, Yingyi Kong, Hao Zheng, Tomoji Mashimo, Tatsuhiko Imaoka, Shinya Toyokuni Abstract Malignant mesothelioma (MM) is still a social burden associated with asbestos exposure. Local iron accumulation thereby represents the major pathogenesis, followed by oxidative DNA strand breaks and genomic alterations in the mesothelium.…

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Multimodal therapy of epithelioid pleural mesothelioma: improved survival by changing the surgical treatment approach

Translational Lung Cancer Research 2022 November [Link] Laura V Klotz, Hans Hoffmann, Rajiv Shah, Florian Eichhorn, Christiane Gruenewald, Elena L Bulut, Raffaella Griffo, Thomas Muley, Petros Christopoulos, Philip Baum, Peter Huber, Seyer Safi, Marc Kriegsmann, Michael Thomas, Helge Bischoff, Hauke Winter, Martin E Eichhorn Abstract Background: The exact role and type of surgery for malignant…

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Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update

International Journal of Molecular Sciences 2022 December 6 [Link] Phillip Munson, Arti Shukla Abstract Malignant mesothelioma (MM) is a devastating cancer of mesothelial cells, caused by asbestos exposure. Limited knowledge regarding the detection of asbestos exposure and the early diagnosis of MM, as well as a lack of successful treatment options for this deadly cancer,…

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Identification of a new potential plasmatic biomarker panel for the diagnosis of malignant pleural mesothelioma

La Medicina del Lavoro 2022 December 7 [Link] Luca Ferrari, Simona Iodice, Laura Cantone, Barbara Dallari, Laura Dioni, Lorenzo Bordini, Alessandro Palleschi, Carolina Mensi, Angela Cecilia Pesatori Abstract Background: Malignant pleural mesothelioma (MPM) is a rare highly aggressive tumor strongly associated with asbestos exposure and characterized by poor prognosis. Currently, diagnosis is based on invasive…

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