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Mesothelioma-Line

Curated Journal Articles on Mesothelioma

Category Archives: Causation

Articles dealing with the factors influencing the development of mesothelioma; occupational asbestos exposure is among the most common, but also genetic predisposition, smoking, and other contributing factors.

Asbestos Fiber Concentrations in the Lungs of Brake Repair Workers: An Updated Analysis Using Several Regression Methods to Handle Non-Detectable Measurements

Journal of Occupational and Environmental Medicine 2018 March [Epub ahead of print] [Link] Liu Y1, Marsh GM, Roggli VL Abstract OBJECTIVES: To reanalyze an updated database of lung asbestos fiber levels for 21 brake repair workers who died of mesothelioma using robust maximum likelihood-based regression methods to address non-detectable measurements. METHODS: We applied bivariate normal […]

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Environmental asbestos exposure and mesothelioma cases in Bari, Apulia region, southern Italy: a national interest site for land reclamation

Environmental Science Pollution Research International 2018 March 5 [Epub ahead of print] [Link] Vimercati L, Cavone D, Lovreglio P, De Maria L, Caputi A, Ferri GM, Serio G Abstract Asbestos is an environmental carcinogen, and asbestos-related diseases are a global-scale public health issue. We report three cases (one male and two females) of pleural malignant […]

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DNA methylation profiling of asbestos-treated MeT5A cell line reveals novel pathways implicated in asbestos response

Archives of Toxicology 2018 March [Epub ahead of print] [Link] Casalone E et. al. Abstract Occupational and environmental asbestos exposure is the main determinant of malignant pleural mesothelioma (MPM), however, the mechanisms by which its fibres contribute to cell toxicity and transformation are not completely clear. Aberrant DNA methylation is a common event in cancer […]

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Asbestos fiber length and its relation to disease risk

Inhalation Toxicology 2017 Oct to December [Link] Barlow CA, Grespin M, Best EA Abstract Differences in chemical and crystalline composition, fiber dimension, aerodynamic characteristics and biodurability are among the critical factors that define the toxicological and pathological consequences of asbestos exposure. Specifically, fiber dimension can impact whether the fiber is respired, whether and how deeply […]

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Heterogeneous Contributing Factors in MPM Disease Development and Progression: Biological Advances and Clinical Implications

International Journal of Molecular Science 2018 January 13 [Link] Tolani B, Acevedo LA, Hoang NT, He B Abstract Malignant pleural mesothelioma (MPM) tumors are remarkably aggressive and most patients only survive for 5-12 months; irrespective of stage; after primary symptoms appear. Compounding matters is that MPM remains unresponsive to conventional standards of care; including radiation […]

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Chest physician-reported, work-related, long-latency respiratory disease in Great Britain

The European Respiratory Journal 2017 December [Link] Carder M, Darnton A, Gittins M, Stocks SJ, Ross D, Barber CM, Agius RM Abstract Much of the current burden of long-latency respiratory disease (LLRD) in Great Britain is attributed to historical asbestos exposure. However, continuing exposure to other agents, notably silica, also contributes to disease burden. The […]

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Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease

Journal of Investigative Medicine 2018 January 6 [Epub ahead of print] [Link] Solbes E, Harper RW Abstract Asbestos comprises a group of fibrous minerals that are naturally occurring in the environment. Because of its natural properties, asbestos gained popularity for commercial applications in the late 19th century and was used throughout the majority of the […]

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The epidemiology of malignant mesothelioma in women: gender differences and modalities of asbestos exposure

Occupational and Environmental Medicine 2017 December 21 [Epub ahead of print] [Link] Marinaccio A, et. al. Abstract INTRODUCTION: The epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register. METHODS: Incident malignant mesothelioma (MM) […]

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Asbestos fibre burden in gallbladder: A case study

Micron 2017 Dec 8 [Epub ahead of print] [Link] Croce A, Capella S, Belluso E, Grosso F, Mariani N, Libener R, Rinaudo C Abstract The methods conventionally used to determine the burden of asbestos fibres inhaled/incorporated in lung require chemical digestion of the biological matrix before counting/characterising the inorganic fibrous phases under scanning electron microscopy […]

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Risk of cancer associated with residential exposure to asbestos insulation: a whole-population cohort study

The Lancet. Public Health [Epub Nov 2 2017] [Link] Korda RJ, Clements MS, Armstrong BK, Law HD, Guiver T, Anderson PR, Trevenar SM, Kirk MD Abstract BACKGROUND: The health risks associated with living in houses insulated with asbestos are unknown. Loose-fill asbestos was used to insulate some houses in the Australian Capital Territory (ACT). We […]

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