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Curated Journal Articles on Mesothelioma

Category Archives: Causation

Articles dealing with the factors influencing the development of mesothelioma; occupational asbestos exposure is among the most common, but also genetic predisposition, smoking, and other contributing factors.

The role of apoptosis defects in malignant mesothelioma pathogenesis with an impact on prognosis and treatment.

Cancer Chemotherapy and Pharmacology 2019 May 22 [Link] Galani V, Varouktsi A, Papadatos SS, Mitselou A, Sainis I, Constantopoulos S, Dalavanga Y Abstract Malignant mesothelioma (MM) is a highly aggressive tumor that is strongly related to asbestos fiber exposure. The tumorigenesis procedure in MM is complex, and many pathogenetic mechanisms including chronic inflammation, deregulation of […]

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Validation of an Asbestos Job-Exposure Matrix (AsbJEM) in Australia: Exposure-Response Relationships for Malignant Mesothelioma.

Annals of Work Exposures and Health 2019 May 23 [Link] Kamiya H, Peters S, Sodhi-Berry N, Reid A, Gordon L, de Klerk N, Brims F, Musk AW, Franklin P Abstract OBJECTIVES: An asbestos job-exposure matrix (AsbJEM) has been developed to systematically and cost-effectively evaluate occupational exposures in population-based studies. The primary aim of this study […]

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Quantitative relationships of exposure to chrysotile asbestos and mesothelioma mortality.

American Journal of Industrial Medicine 2019 June [Link] Loomis D, Richardson DB, Elliott L Abstract BACKGROUND: While asbestos has long been known to cause mesothelioma, quantitative exposure-response data on the relation of mesothelioma risk and exposure to chrysotile asbestos are sparse. METHODS: Quantitative relationships of mortality from mesothelioma and pleural cancer were investigated in an […]

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Whole-genome sequencing of human malignant mesothelioma tumours and cell lines.

Carcinogenesis 2019 April 25 [Link] Oey H, Daniels M, Relan V, Chee TM, Davidson MR, Yang IA, Ellis JJ, Fong KM, Krause L, Bowman RV Abstract Pleural mesothelioma is a cancer of serosal surfaces caused by environmental exposure to asbestos. Clinical outcome remains poor and while trials of new treatments are ongoing it remains an […]

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Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice.

Toxicology and Applied Pharmacology 2019 April 22 [Link] Christofidou-Solomidou M, Pietrofesa RA, Park K, Albelda SM, Serve KM, Keil DE, Pfau JC Abstract BACKGROUND: Exposure to the Libby Amphibole (LA) asbestos-like fibers found in Libby, Montana, is associated with inflammatory responses in mice and humans, and an increased risk of developing mesothelioma, asbestosis, pleural disease, […]

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A case from India of pleural malignant mesothelioma probably due to domestic and environmental asbestos exposure: a posthumous report.

BMJ Case Reports 2019 March 31 [Link] Muralidhar V, Raghav P, Das P, Goel A Abstract India is the largest consumer of asbestos in the world. There is no report from India of mesothelioma related to asbestos. The case is a 42-year-old man who died of pleural mesothelioma. He was exposed to asbestos domestically and […]

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Asbestos fiber identification in liver from cholangiocarcinoma patients living in an asbestos polluted area: a preliminary study.

Tumori 2019 March 27 [Link] Grosso F, Croce A, Libener R, Mariani N, Pastormerlo M, Maconi A, Rinaudo C Abstract PURPOSE:: To assess whether asbestos fibers may be observed in liver tissue of patients with cholangiocarcinoma (CC) with environmental or working asbestos exposure. METHODS:: Detection of fibers was performed directly on histologic sections of liver […]

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In Commemoration of the 2018 Mataro Nagayo Prize – A road to early diagnosis and monitoring of asbestos-related mesothelioma.

Cancer Science 2019 March 19 [Link] Hino O, Abe M, Han B, Yan Y Abstract Primarily caused by exposure to asbestos, mesothelioma is a typical occupational disease. The latency of mesothelioma is as long as 20-40 years, and the cancer initially progresses mainly along the surfaces of pleura or peritoneum without forming masses. Since the […]

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The toxicology of chrysotile-containing brake debris: implications for mesothelioma.

Critical Reviews in Toxicology 2019 March 15 [Link] Poland CA, Duffin R Abstract The global use of “asbestos” in various commercial products has led to a wide range and pervasive legacy of disease. One such use of chrysotile asbestos was brake pads and was utilized commonly in automobiles and heavy vehicles. The result of incorporation […]

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Environmental asbestos exposure in childhood and risk of mesothelioma later in life: a long-term follow-up register-based cohort study.

Occupational and Environmental Medicine 2019 February 25 [Link] Dalsgaard SB, Würtz ET, Hansen J, Røe OD, Omland Ø Abstract OBJECTIVE: To examine the risk of malignant mesothelioma (MM) in former pupils who attended primary school near an asbestos cement plant. METHODS: A cohort of 12 111 former pupils, born 1940-1970, was established from individual historical records […]

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