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Curated Journal Articles on Mesothelioma

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Should Lung-Sparing Surgery Be the Standard Procedure for Malignant Pleural Mesothelioma?

Journal of Clinical Medicine 2020 July 8 [Link] Yoshinobu Ichiki, Hidenori Goto, Takashi Fukuyama, Kozo Nakanishi Abstract Background: Surgical procedures for malignant pleural mesothelioma (MPM) include extrapleural pneumonectomy (EPP), extended pleurectomy/decortication (P/D) and P/D. EPP has been applied to MPM for a long time, but the postoperative status is extremely poor due to the loss […]

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Acute kidney injury after cytoreductive surgery and hyperthermic intraoperative cisplatin chemotherapy for malignant pleural mesothelioma

The Journal of Thoracic and Cardiovascular Surgery 2020 May 29 [Link] Tammy Hod, Katherin J Freedberg, Shveta S Motwani, Margaret Chen, Gyorgy Frendl, David E Leaf, Shruti Gupta, Suraj Sarvode Mothi, William G Richards, Raphael Bueno, Sushrut S Waikar Abstract Objectives: Cytoreductive surgery with hyperthermic intraoperative chemotherapy with cisplatin has been used successfully to treat […]

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Clinical Features in Patients With Malignant Pleural Mesothelioma With 5-Year Survival and Evaluation of Original Diagnoses

Clinical Lung Cancer 2020 May 23 [Link] Juuso Paajanen, Sanna Laaksonen, Ilkka Ilonen, Tapio Vehmas, Mikko I Mäyränpää, Eva Sutinen, Eeva Kettunen, Jarmo A Salo, Jari Räsänen, Henrik Wolff, Marjukka Myllärniemi Abstract Introduction: Malignant pleural mesothelioma (MPM) is a fatal malignancy strongly associated with previous asbestos exposure. Overall survival remains dismal, partly owing to poor […]

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TLD1433-Mediated Photodynamic Therapy with an Optical Surface Applicator in the Treatment of Lung Cancer Cells In Vitro

Pharmaceuticals 2020 June 28 [Link] Sarah Chamberlain, Houston D Cole, John Roque 3rd, David Bellnier, Sherri A McFarland, Gal Shafirstein Abstract Intra-operative photodynamic therapy (IO-PDT) in combination with surgery for the treatment of non-small cell lung cancer and malignant pleural mesothelioma has shown promise in improving overall survival in patients. Here, we developed a PDT […]

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A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma

The Oncologist 2020 July 1 [Link] Carl M Gay, Yanhong Zhou, J Jack Lee, Xi Ming Tang, Wei Lu, Ignacio I Wistuba, Renata Ferrarotto, Don L Gibbons, Bonnie S Glisson, Merrill S Kies, George R Simon, John V Heymach, Anne S Tsao Abstract Lessons learned: Treatment with the Aurora kinase A inhibitor yields often durable […]

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Lamellar Inclusions within Hyperplastic Endoplasmic Reticulum in Benign Mesothelial Cells

Acta Cytologica 2020 June 29 [Link] Simon Haefliger, Deepali Jain, Thomas Menter, Tatjana Vlajnic, Spasenija Savic Prince, Helmut Hopfer, Michael J Mihatsch, Lukas Bubendorf Abstract Introduction: In effusion cytology, mesothelial cells can occasionally present with striking intracytoplasmic accumulation of rod- and crystal-like cytoplasmic lamellar inclusions (LIs). Their nature and function are poorly understood, and their […]

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Predictors of Filing Claims and Receiving Compensation in Malignant Mesothelioma Patients

Health Policy 2020 June 10 [Link] Alessandro Marinaccio, Claudio Gariazzo, Davide Di Marzio, Sergio Iavicoli, ReNaM Working Group Abstract Although the predominant occupation origin of mesothelioma is well known, determinant factors involved in filing compensation are scarcely investigated. A linkage between incident mesothelioma cases collected by Italian mesothelioma register (ReNaM) and compensation claims and assignment […]

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Questioning the Prognostic Role of BAP-1 Immunohistochemistry in Malignant Pleural Mesothelioma: A Single Center Experience With Systematic Review and Meta-Analysis

Lung Cancer 2020 June 21 [Link] Luca Cantini, Federica Pecci, Alberto Murrone, Marco Tomasetti, Cecilia Copparoni, Ilaria Fiordoliva, Francesca Morgese, Silvia Rinaldi, Paola Mazzanti, Corrado Rubini, Alessia Cimadamore, Francesca Barbisan, Riccardo Giampieri, Marina Scarpelli, Lory Santarelli, Rossana Berardi Abstract Introduction: The prognostic role of BRCA1 associated protein-1 (BAP1) expression in malignant pleural mesothelioma (MPM) is […]

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Involvement of the M-CSF/IL-34/CSF-1R Pathway in Malignant Pleural Mesothelioma

Journal for the Immunotherapy of Cancer 2020 June [Link] Thibaut Blondy, Sènan Mickael d’Almeida, Tina Briolay, Julie Tabiasco, Clément Meiller, Anne-Laure Chéné, Laurent Cellerin, Sophie Deshayes, Yves Delneste, Jean-François Fonteneau, Nicolas Boisgerault, Jaafar Bennouna, Marc Grégoire, Didier Jean, Christophe Blanquart Abstract Background: Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos […]

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Cellular Immunotherapy and Locoregional Administration of CAR T-Cells in Malignant Pleural Mesothelioma

Frontiers in Oncology 2020 June 3 [Link] Robert A Belderbos, Heleen Vroman, Joachim G J V Aerts Abstract Malignant pleural mesothelioma (MPM) is a treatment recalcitrant tumor with a poor overall survival (OS). Current approved treatment consists of first line chemotherapy that only modestly increases OS, illustrating the desperate need for other treatment options in […]

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