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Archive for the 'Raltitrexed (Tomudex)' Category

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November 26th, 2008. Mesothelioma: treatment

There are few active cytotoxic drugs in this disease. Currently, based on two randomised trials, the most efficacious chemotherapy regimen consists in a combination of cisplatin and an antifolate agent, pemetrexed or raltitrexed.
Posted in Chemotherapy, Cisplatin (Platinol ®), Full Archive, Pemetrexed (Alimta), Pleural, Pleurectomy/decortication, Pneumonectomy, Radiation, Raltitrexed (Tomudex), Surgery, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

September 5th, 2008. Systemic Treatments for Mesothelioma: Standard and Novel

These include drugs targeted against the epidermal growth factor, platelet-derived growth factor, vascular endothelial growth factor, src kinase, histone deacetylase, the proteasome, and mesothelin. Given the progress made in recent years, there is reason to believe that more effective treatments will continue to be developed.
Posted in Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, EGFR, Full Archive, Gemcitabine (Gemzar), General, Irinotecan, Kinase Inhibitors, New & Novel, Pemetrexed (Alimta), Raltitrexed (Tomudex), Staging, Treatment, Type of Assessment:, Vinorelbine | No Comments »

December 21st, 2007. Symptoms and patient-reported well-being: do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma

Conclusion: Results suggest that the PI, pain, and appetite loss may be independent prognostic factors in patients with advanced MPM.
Posted in Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, Full Archive, Pleural, Raltitrexed (Tomudex), Symptoms & Symptom Management, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

August 4th, 2007. Multidisciplinary Treatment of Malignant Pleural Mesothelioma

However, currently available treatments still appear to have modest results. Further studies are needed to provide evidence-based recommendations for the treatment of early and advanced stages of this disease.
Posted in Chemotherapy, Determining Efficacy, Extrapleural Pneumonectomy (EPP), Full Archive, New & Novel, Pemetrexed (Alimta), Pleural, Radiation, Raltitrexed (Tomudex), Surgery, Treatment, Trimodality Therapy, Type of Assessment:, Type of Mesothelioma: | No Comments »

April 6th, 2007. The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline

Conclusions: There is good evidence to recommend chemotherapy with pemetrexed and cisplatin for adult patients with symptomatic advanced malignant pleural mesothelioma. Such treatment should be administered with supplementation of vitamin B12 and folic acid. If pemetrexed is not available, cisplatin plus raltitrexed is a reasonable alternative.
Posted in Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, Full Archive, Pemetrexed (Alimta), Pleural, Raltitrexed (Tomudex), Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

January 30th, 2006. Short-Term Treatment-Related Symptoms and Quality of Life: Results From an International Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma: An EORTC Lung-Cance

Conclusion: This study provides important information about the HRQOL of chemotherapy-treated MPM patients.
Posted in Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, Full Archive, Pleural, Raltitrexed (Tomudex), Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

December 14th, 2005. Mesothelioma: advances in chemotherapy

Some preliminary data from studies of second line chemotherapy is also available. Finally studies of targeted therapies such as anti-EGFR, anti VEGF and anti PDGF are underway but have not as yet demonstrated major therapeutic benefit.
Posted in Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, EGFR, Full Archive, Gemcitabine (Gemzar), Pemetrexed (Alimta), Raltitrexed (Tomudex), Treatment, Type of Assessment:, Vinorelbine | No Comments »

October 1st, 2005. Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma

Conclusion: A combination of raltitrexed and cisplatin improves overall survival compared with cisplatin alone. This study confirms that a combination of cisplatin and an antifolate is superior to cisplatin alone in patients with MPM, without harmful effect on HRQOL.
Posted in Chemotherapy, Cisplatin (Platinol ®), Full Archive, Pleural, Raltitrexed (Tomudex), Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

July 1st, 2005. Management of malignant pleural effusions

With regard to mesothelioma, recent chemotherapy trials with pemetrexed/cisplatin and raltitrexed/cisplatin are encouraging and appear, for the first time, to offer a small but real survival advantage. Summary: In the authors' opinion, the major developments in the management of malignant effusions during the past year are the development of safer pleurodesis agents and the promise of better combination chemotherapy agents for the treatment of mesothelioma.
Posted in Chemotherapy, Cisplatin (Platinol ®), Full Archive, Pemetrexed (Alimta), Pleural Effusion, Raltitrexed (Tomudex), Symptoms & Symptom Management, Treatment, Type of Assessment: | No Comments »

January 24th, 2005. Raltitrexed-Oxaliplatin combination chemotherapy is inactive as second-line treatment for malignant pleural mesothelioma patients

85, range: 7-20), while median overall survival was just 14 weeks (average: 21. 69, range: 9-66+).
Posted in Full Archive, Oxaliplatin (Eloxatin), Raltitrexed (Tomudex), Treatment | No Comments »
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