Archive for the 'Pleural Effusion' Category
An abnormal accumulation of fluid in the pleural space.
June 1st, 2007. MN/CA9: a potential gene marker for detection of malignant cells in effusions
Our preliminary results suggest that MN/CA9 could be a potential marker for the detection of malignant cells in effusions. A large-scale study is needed to confirm these results.
May 15th, 2007. Diagnostic utility of D2-40 and podoplanin in effusion cell blocks
It is concluded that D2-40 and podoplanin are very useful markers for mesotheliomas. Since these markers are extremely helpful in differentiating epithelioid mesothelioma from metastatic adenocarcinoma, they shall be a valuable addition to the battery of markers used to differentiate the two entities.
April 19th, 2007. Chemokine receptors are infrequently expressed in malignant and benign mesothelial cells
This finding suggests a major role for an autocrine chemokine pathway in leukocytes but not in MM cells. The increased monocyte infiltration and their higher chemokine receptor expression in MM effusions may have a tumor-promoting rather than tumor-inhibiting effect.
April 17th, 2007. A large abdominal wall mass as an initial manifestation of malignant mesothelioma
Despite further radiotherapy, the patient died of cardiac tamponade due to tumor invasion 38 months after the initial diagnosis. To the best of our knowledge, this is the first description of malignant mesothelioma presenting via initial invasion of the abdominal wall without changes in the thoracic space.
April 12th, 2007. Catheter-Tract Metastases Associated With Chronic Indwelling Pleural Catheters
7% of 45 patients treated with indwelling pleural catheters for malignant pleural effusions. Both clinicians and patients should be aware of this potential complication.
March 30th, 2007. Value of antimesothelioma HBME-1 in the diagnosis of inflammatory and malignant pleural effusions
33%) cases; the staining pattern in metastatic adenocarcinoma cells was thin membrane and focal cytoplasmic. HBME-1 has a moderate sensibility and specificity for mesothelial cells and can be used as part of a panel for differentiation of malignant and reactive mesothelial cells from adenocarcinoma in pleural effusions.
March 29th, 2007. Medical thoracoscopy in an Australian regional hospital
There was one fatality caused by pre-existing sepsis in a debilitated patient with disseminated carcinoma. Medical thoracoscopy is a simple, safe and cost-effective technique for diagnosing and treating pleural effusions and provides a useful service in the setting of a regional hospital.
March 23rd, 2007. Cytological diagnosis of malignant mesothelioma–improvement by additional analysis of hyaluronic acid in pleural effusions
The addition of HA analysis to cytology, requiring all or some criteria of MM as positive, increased sensitivity for MM from 48 to 71–91%, whereas specificity only slightly decreased to 94–96%. We conclude that the combined cytological and HA analysis of pleural effusions had the potential to improve the diagnosis of MM.
March 17th, 2007. Biphasic malignant mesothelioma cases with osseous differentiation and long survival: A review of the literature
Both patients survived 39 and 69 months, respectively. To our knowledge, these two cases with biphasic malignant mesothelioma and osseous differentiation with long survival are the first to be described from Central Anatolia.
March 16th, 2007. Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma
Conclusions: Measurement of mesothelin concentrations in the pleural and/or peritoneal effusion of patients may aid in the differential diagnosis of mesothelioma in patients presenting with effusions.
January 26th, 2007. Talc mediates angiostasis in malignant pleural effusions via endostatin induction
In conlusion, talc alters the angiogenic balance in the pleural space from a biologically active and angiogenic environment to an angiostatic milieu. Functional improvement following talc poudrage in patients with malignant pleural effusions may, in part, reflect these alterations in the pleural space.
January 19th, 2007. Kallikrein 4 is expressed in malignant mesothelioma – Further evidence for the histogenetic link between mesothelial and epithelial cells
In conclusion, hK4 is frequently expressed in MM, with higher levels detected in solid tumors, although its expression is more limited than in gynecological adenocarcinomas. The presence of hK4 in MM, a non-hormonally regulated tumor, provides further support to the histogenetic link between mesothelial and epithelial cells.
September 27th, 2006. Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression
E-cadherin, N-cadherin and P-cadherin expression was found in 69/110 (63%), 87/110 (79%) and 84/110 (76%) MM cases, respectively. Pleural and peritoneal MM showed comparable expression, but all three cadherins were upregulated in effusions compared to solid tumors (p.
September 25th, 2006. Recurrent pneumothorax as alone manifestation of mesothelioma pleurae
Specimens of lung and pleurae were examinated. Result of microscopic and immunohistochemical examination was: mesothelioma epithelioides pleurae (mesothelium +, calretyninaa +, EMA+ membrane reaction, desmine +/-).
September 15th, 2006. Malignant mesothelioma: A ten years experience
Discussion: As demonstrated by the small series in ten years, malignant mesothelioma is a rare tumour. Relationship with asbestos exposure was proven in 67% of cases. Chemotherapy associated with talc pleurodesis increased survival and palliated symptoms.
Posted in Carboplatin, Causation, Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, Diagnosis & Differentiation, Full Archive, Gemcitabine (Gemzar), General, Occupational Asbestos Exposure, Pemetrexed (Alimta), Pleural Biopsy, Pleural Effusion, Pneumonectomy, Radiation, Surgery, Survival, Symptoms & Symptom Management, Treatment, Type of Assessment: | No Comments »
September 6th, 2006. A Molecular Diagnostic Test for Distinguishing Lung Adenocarcinoma from Malignant Mesothelioma Using Cells Collected from Pleural Effusions
Conclusions: We have developed a test that is able to distinguish between lung adenocarcinoma and mesothelioma in cells collected from pleural effusions.
July 22nd, 2006. The Diagnosis of Malignancy in Effusion Cytology: A Pattern Recognition Approach
In addition, the role of ancillary studies in challenging cases and the importance of integrating clinical findings are stressed. An algorithmic approach to the workup of serous effusions as well as pitfalls for false-positive diagnosis are discussed.
July 19th, 2006. Imaging of pleural disease
The conditions covered include benign and malignant pleural thickening, pleural effusions, empyema and pneumothoraces. The relative merits of CT, MRI and PET in the assessment of these conditions and the role of image-guided intervention are discussed.
Posted in Benign, CT or CAT scan, Diagnosis & Differentiation, Full Archive, MRI, PET Scan, Pleural, Pleural Effusion, Symptoms & Symptom Management, Type of Assessment:, Type of Mesothelioma: | No Comments »
July 5th, 2006. D2-40 is Not a Specific Marker for Cells of Mesothelial Origin in Serous Effusions
Pulmonary, breast, and nonovarian gynecologic tumors usually showed weak focal membranous staining, whereas the ovarian adenocarcinomas showed an expression pattern more similar to mesotheliomas. The results from the present study suggest low specificity for D2-40 as a mesothelial marker, especially in the context of differentiating mesothelial cells from ovarian carcinoma, and argue against its inclusion in the diagnostic panel of serous effusions.
July 3rd, 2006. Alteration of pemetrexed excretion in the presence of acute renal failure and effusions: presentation of a case and review of the literature
Dialysis was unsuccessful in removing pemetrexed. Theoretical and practical approaches to management of similar cases are presented.
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