Archive for the 'Pleural Effusion' Category
An abnormal accumulation of fluid in the pleural space.
January 6th, 2009. Telomerase Activity in Effusions: A Comparison Between Telomere Repeat Amplification Protocol In Situ and Conventional Telomere Repeat Amplification Protocol Assay
Conclusions: The TRAP in situ results correlated to final diagnoses, whereas the cell lysate–based TRAP assay did not differentiate between malignant and benign cases. The varying proportions of positive cells and the variation in fluorescence intensity in the TRAP in situ slides explained some of the discrepancies. The problems encountered with TRAP performed on cell lysates are partly overcome using TRAP in situ.
December 25th, 2008. Malignant pleural effusion as the presenting site of cancer: comparison with metastatic pleural effusions from known cancers
Conclusion: Pleural effusions as the presenting site of cancer account for 41% of all malignant pleural effusions. Their causes are mainly lung cancer in men and lung and ovarian cancers in women.
December 18th, 2008. Medical thoracoscopic talc pleurodesis for malignant pleural effusion: an analysis of 27 cases
Conclusion: Medical thoracoscopic talc poudrage pleurodesis is a safe and effective method for the treatment of malignant pleural effusion.
November 11th, 2008. Role of viral induced vascular endothelial growth factor (VEGF) production in pleural effusion and malignant mesothelioma
To show the specific effect of viral receptors knockdown experiments with siRNA for TLR3, RIG-I and MDA5 were performed. This finding of viral induced mesothelial VEGF synthesis may indicate a novel link between viral infections and formation of pleural effusions and progression of malignant mesothelioma.
November 8th, 2008. Transudates in Malignancy: Still a Role for Pleural Fluid
Conclusions: Cytological examination of pleural fluid in patients with unexplained transudative effusion is essential to rule out malignant processes.
October 31st, 2008. Semi-rigid thoracoscopy for undiagnosed exudative pleural effusions: a comparative study
Conclusions: Medical thoracoscopy is a simple, safe, and cost-effective tool, with a high positive rate. Physicians should extend its access to proper patients if the facilities for medical thoracoscopy are available.
October 22nd, 2008. A case of solid pseudopapillary tumour of the pancreas and malignant mesothelioma
Discussion: An abdominal computerised tomogram revealed pancreatic body mass arising. Pleural fluid cytology and a pleural biopsy failed to demonstrate malignancy. The pancreatic tumour was resected by distal pancreatectomy, segmental colectomy and splenectomy. The tumour was a solid pseudopapillary pancreatic tumour (SPT) with a high metastatic potential. The patient deteriorated and a repeat biopsy of the thickened pleura confirmed malignancy which was initially thought to be metastases from the SPT. Immunohistochemical staining confirmed malignant mesothelioma. The patient developed liver metastases and died 2 years from the diagnosis of metastatic disease.
Posted in CT or CAT scan, Case Study, Diagnosis & Differentiation, Full Archive, Immunohistochemistry or IHC, Pleural Effusion, Surgery, Survival, Symptoms & Symptom Management, Treatment, Type of Assessment: | No Comments »
October 18th, 2008. Expression and Regulation of Epithelial Na+ Channels by Nucleotides in Pleural Mesothelial Cells
Furthermore, we found that both forskolin and cGMP increased the short-circuit currents in mouse pleural tissues. Taken together, our data demonstrate that the ENaC channels are biochemically and functionally expressed in human pleural mesothelial cells, and can be up-regulated by cAMP and cGMP.
October 16th, 2008. Cardiac tamponade as primary manifestation of angioimmunoblastic T-cell lymphoma (AILT). Coexistence with malignant mesothelioma
Conclusion: CT as primary clinical manifestation of AILT is very rare. This case reflects the differences in the underlying biology of AILT and consequently the vast spectrum of its clinical presentations. Coexistence of AILT with malignant pleural mesothelioma is also extremely rare.
September 23rd, 2008. Pleural fluid findings as prognostic factors for malignant pleural mesothelioma
However, none of these variables emerged as statistically significant from the multivariate Cox model. In conclusion, our results showed that there is an inverse correlation between the intensity of inflammation and survival.
September 9th, 2008. Clinical consequences of asbestos-related diffuse pleural thickening: A review
It causes a restrictive defect on lung function and may rarely result in respiratory failure and death. Treatment is primarily supportive.
Posted in CT or CAT scan, Causation, Diagnosis & Differentiation, Environmental Asbestos Exposure, Full Archive, Occupational Asbestos Exposure, PET Scan, Pleural Effusion, Symptoms & Symptom Management, Treatment, Type of Assessment: | No Comments »
June 28th, 2008. Mesothelioma and Asbestos-Related Pleural Diseases
We summarized the most relevant data for the diagnosis and the management of benign asbestos pleural effusions, pleural plaques, diffuse pleural thickening and rounded atelectasis. Special attention is dedicated to malignant pleural mesothelioma, given the challenging issues of this disease, the recent advances in its management and the dynamism of research in this area.
June 27th, 2008. Paget disease of the humerus mimicking metastatic disease in a patient with metastatic malignant mesothelioma on whole body F-18 FDG PET/CT
The corresponding CT scan findings of cortical thickening and a "Swiss cheese" appearance were most consistent with Paget disease. The intense FDG uptake in an osseous lesion on FDG-PET in our case reminds us of the variable nature of FDG uptake in Paget disease, the possibility of false-positive findings on FDG-PET in patients with cancer, and the usefulness of the fusion techniques in the evaluation of skeletal lesions, with the potential for discriminating between benign Paget disease and other pathologic bone findings.
June 26th, 2008. Piroxicam and intracavitary platinum-based chemotherapy for the treatment of advanced mesothelioma in pets: preliminary observations
The therapy was able to arrest the effusion in all patients for variable remission times: one dog is still in remission after 3 years, one dog died of progressive disease after 8 months and one cat died due to progressive neoplastic growth after six months, when the patient developed a mesothelial cuirass. The combination showed remarkable efficacy at controlling the malignant effusion secondary to MM in our patients and warrants further investigations.
June 13th, 2008. Pericardial effusion due to metastatic prostate cancer: a case report
He died suddenly because of ventricular tachycardia. At autopsy, the major finding was poorly differentiated adenocarcinoma of the prostate with metastases to the mediastinum.
June 4th, 2008. An autopsy case of diffuse pleural thickening presented respiratory impairment and benign asbestos pleurisy
The autopsy disclosed asbestos-related lung diseases. We suspected that diffuse pleural thickening could be a major cause of fatal respiratory impairment in this case.
Posted in CT or CAT scan, Case Study, Causation, Diagnosis & Differentiation, Full Archive, Occupational Asbestos Exposure, Pleural Biopsy, Pleural Effusion, Symptoms & Symptom Management, Type of Assessment:, thoracoscopy | No Comments »
June 3rd, 2008. Metastases in malignant pleural mesothelioma: A new radiological appearance
This radiological pattern of metastases has never been described before. The patient died from respiratory failure related to extensive parenchymal metastases, an outcome seldom reported with malignant pleural mesothelioma.
May 21st, 2008. Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression
This hyporesponsiveness was evident even in the presence of IL-15, a strong inducer of NKG2D. Our data show that NKG2D is a likely physiological target for exosome-mediated immune evasion in cancer.
May 2nd, 2008. Management of Malignant Pleural Effusion Associated with Trapped Lung Syndrome
Median survival was 126 days (range, 10–175 days). We conclude that long-term placement of a pleural catheter provides effective palliation for malignant pleural effusion associated with trapped lung syndrome.
April 4th, 2008. Establishment of three novel human malignant pleural mesothelioma cell lines: morphological and cytogenetical studies and EGFR mutation status
Conclusion: FACS analysis is more sensitive for evaluating mesothelin expression than immunohistochemistry of cut specimens. Irrespective of the expression of EGFR on FACS analysis, no EGFR mutation was detected. These three cell lines may be useful for studying cellular, molecular and genetic aspects of mesothelioma.
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