Archive for the 'SV40' Category
Simian Virius 40 polio vaccine.
March 14th, 2007. Erionite and asbestos differently cause transformation of human mesothelial cells
Our results reveal that erionite is able per se to turn HMC into transformed highly proliferating cells and disclose the carcinogenic properties of erionite, prompting for a careful evaluation of environmental exposure to these fibers. The genetic predisposition to the effect of erionite is a separate subject for investigation.
February 23rd, 2007. Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples
No viral DNA was found in the sera. No significant association between SV40 antibody response in prediagnostic sera and risk of mesothelioma was seen.
December 1st, 2006. Relationship between the malignant mesothelioma and simian virus 40 in China: a study of 17 cases
Conclusions: The study shows that malignant mesothelioma in China may be independent of SV40 infection.
November 30th, 2006. SV40 and human cancer: A review of recent data
In epidemiologic studies, the increased incidence of some of the suspect tumors in the 1970s to 1980s was not related to the risk of exposure to SV40-contaminated vaccines. In summary, the most recent evidence does not support the notion that SV40 contributed to the development of human cancers.
November 17th, 2006. A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent
In contrast, cell lines developed from mesothelial cells of animals carrying multiple copies of TAg were growth factor independent and could be cloned at limiting dilution in soft agar. These data provide the first in vivo demonstration of co-carcinogenicity between SV40 and asbestos.
November 9th, 2006. Mesothelioma mortality in Europe: impact of asbestos consumption and simian virus 40
Conclusion: Using the currently existing data on SV40 prevalence, no association between SV40 prevalence and asbestos-corrected male pleural cancer can be demonstrated.
October 17th, 2006. The pathogenesis of mesothelioma
These findings indicate that the risk varies among asbestos- and erionite-exposed individuals because of their genetic background or because of exposure to other carcinogens. Moreover, these data provide a rationale for the observation that only a fraction of heavily exposed asbestos workers developed mesothelioma, and novel targets for prevention and therapy.
October 13th, 2006. Epidemiology of peritoneal mesothelioma: a review
The role of other suspected risk factors, such as simian virus 40 infection and genetic predisposition, is unclear at present. Control of asbestos exposure remains the main approach to prevent peritoneal mesothelioma.
September 13th, 2006. Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
Significantly lower amounts of asbestos were sufficient to cause MM in animals infected with SV40. Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40.
August 22nd, 2006. The Role of SV40 in Malignant Mesothelioma and Other Human Malignancies
Some have suggested that SV40 may act as a cocarcinogen with asbestos to cause mesothelioma formation, or that it may be responsible for the 10-20% of mesotheliomas with no reported history of asbestos exposure. This report briefly covers the historical evidence for SV40 carcinogenesis and then covers experiments now underway to better understand the role of SV40 in human mesotheliomas.
July 27th, 2006. p53-Induced Apoptosis Occurs in the Absence of p14(ARF) in Malignant Pleural Mesothelioma
However, it is noteworthy that only survivin downregulation sensitized cells to CDDP-induced apoptosis. These results suggest that p53 is functional in the absence of p14(ARF) in MPM and that targeting of the downstream apoptosis inhibitor survivin can sensitize to CDDP-induced apoptosis.
June 30th, 2006. [In Process Citation] (Health among mechanics exposed to asbestos and SV40-contaminated polio vaccines)
We didn't find pleural or pulmonary malignancies; besides 4 doubtful neoplasms required further investigations. Although exiguity of sample, these findings provide a lack of mesothelioma and lung cancer among mechanics, previously exposed to asbestos and infected by SV40.
June 26th, 2006. Cellular and molecular parameters of mesothelioma
More importantly, serum proteomics has revealed two new candidates (osteopontin and serum mesothelin-related protein or SMRP) potentially useful in screening individuals for MMs. These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors.
April 30th, 2006. Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma model
All of the antibodies we tested (HGF, Notch, VEGF, Sp1, p53, PP2A, p-ERK1, p-c-jun, Fra1, Fra2, MMP1, MMP9, NFkappaB p65, IkappaB, GAPDH) cross-reacted with their hamster counterparts. These data indicate that hamster mesothelioma model and more in general hamster experimental model, can be used for functional studies because many mouse, rabbit, and goat monoclonal antibodies prepared against human antigens cross-react with their hamster counterparts.
April 25th, 2006. Infrequent existence of simian virus 40 large T antigen DNA in malignant mesothelioma in Japan
None of the 35 malignant mesothelioma specimens showed immunoreactivity for SV40 large T antigen. SV40 infection does not appear to have a major role in the development of malignant mesothelioma in Japan.
April 25th, 2006. Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients
To characterize the biological differences between Y-MESO-8A and Y-MESO-8D, we carried out cDNA microarray analysis and detected genes that were differentially expressed in these two cell lines. Thus, our new MPM cell lines seem to be useful as new models for studying various aspects of the biology of human MPM as well as materials for the development of future therapies.
Posted in Biphasic or Mixed, Epithelioid, Full Archive, Gene Therapy, New & Novel, Pleural, SV40, Sarcomatoid, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »
April 23rd, 2006. Epidemiologic studies of polyomaviruses and cancer: previous findings, methodologic challenges and future directions
Overall, the results from these studies were mostly null, although limitations in study design and exposure assessment complicate their interpretation. This chapter includes a review of results from previous epidemiologic studies of polyomavirus infection and human cancer, discussion of the methodologic challenges in study design, and proposed future directions for epidemiologic research.
April 1st, 2006. Malignant mesothelioma
Multimodality regimens are being evaluated to improve upon the current outcome of these patients. With greater understanding of the molecular mechanisms underlying the pathogenesis of mesothelioma, there is hope of developing novel agents that are more effective.
Posted in Causation, Chemotherapy, Diagnosis & Differentiation, Epidemiological, Extrapleural Pneumonectomy (EPP), Full Archive, New & Novel, Occupational Asbestos Exposure, SV40, Surgery, Survival, Treatment, Type of Assessment: | No Comments »
March 29th, 2006. Polio vaccines, SV40 and human tumours, an update on false positive and false negative results
The same 20 mesothelioma specimens all tested negative, 2/20 tested positive or 7/20 tested positive for SV40 Tag by simply changing the detection method on the same immuno-precipitation/western blot membranes. These results provide a simple explanation for some of the apparent discordant results reported in the literature.
February 8th, 2006. Descriptive epidemiology of malignant mesothelioma
Conclusions: World production of asbestos has been declining dramatically in recent years, however increases have occurred in Asia. The decrease in asbestos use and a ban in several industrialized countries have proved effective in reducing the societal burden of MM.
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